دورية أكاديمية
Renal Transplantation in HIV-positive and HIV-negative People With Advanced Stages of Kidney Disease: Equity in Transplantation.
| العنوان: | Renal Transplantation in HIV-positive and HIV-negative People With Advanced Stages of Kidney Disease: Equity in Transplantation. |
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| المؤلفون: | Hosseini-Moghaddam SM; ICES, Kidney, Dialysis & Transplantation Research Program, London, Ontario, Canada.; Multiorgan Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.; Division of Infectious Diseases, Department of Medicine, Western University, London, Ontario, Canada., Kang Y; ICES, Kidney, Dialysis & Transplantation Research Program, London, Ontario, Canada.; Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada., Bota SE; ICES, Kidney, Dialysis & Transplantation Research Program, London, Ontario, Canada.; Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada., Weir MA; ICES, Kidney, Dialysis & Transplantation Research Program, London, Ontario, Canada.; Division of Nephrology, Department of Medicine, Western University, London, Ontario, Canada.; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada. |
| المصدر: | Open forum infectious diseases [Open Forum Infect Dis] 2024 Apr 16; Vol. 11 (5), pp. ofae182. Date of Electronic Publication: 2024 Apr 16 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]- |
| مستخلص: | Background: People with HIV are at a greater risk of end-stage kidney disease than the general population. Considering the risk of death after end-stage kidney disease, access to renal transplantation in people with HIV is critically important. Methods: We included all adult patients on chronic dialysis in Ontario, Canada, between 1 April 2007 and 31 December 2020. We determined the probability of kidney transplantation with competing risk of death over time since the initiation of dialysis by calculating the adjusted subdistribution hazard ratios (sdHR; 95% confidence interval [CI]). We also compared long-term renal allograft and posttransplant mortality outcomes between HIV-negative and HIV-positive persons. Results: Of 40 686 people (median age, 68 years; interquartile range, 57-77; 38.4% women), 173 were HIV-positive and 40 513 were HIV-negative. The incidence of kidney transplantation in HIV-negative and HIV-positive patients was 40.5 (95% CI, 39.4-41.6)/1000 person-years and 35.0 (95% CI, 22.8-53.7)/1000 person-years, respectively ( P = .51). Considering the competing risk of death, HIV-positive people had a significantly lower chance of receiving kidney transplants than HIV-negative people (sdHR, 0.46 [95% CI, .30-.70]). The long-term allograft failure risk was not significantly different between HIV-negative and HIV-positive people, considering the competing risk of posttransplant death (sdHR, 1.71 [95% CI, .46-6.35]). Conclusions: Although the incidence and crude probability of kidney transplantation were similar among HIV-negative and HIV-positive persons in this cohort, those with HIV had a significantly lower likelihood of kidney transplantation than those without HIV. Having HIV was not significantly associated with a poor long-term allograft outcome compared with patients without HIV. Competing Interests: Potential conflicts of interest. All authors report no potential conflicts. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
| References: | PLoS One. 2018 Apr 16;13(4):e0195443. (PMID: 29659605) Kidney Int. 2002 Jan;61(1):195-202. (PMID: 11786101) Clin Infect Dis. 2015 Mar 15;60(6):941-9. (PMID: 25409471) Am J Transplant. 2019 Dec;19(12):3345-3355. (PMID: 31206243) JAMA Surg. 2022 Mar 1;157(3):240-247. (PMID: 34985513) Clin J Am Soc Nephrol. 2017 Mar 7;12(3):467-475. (PMID: 28232406) Med Care. 2015 Sep;53(9):e65-72. (PMID: 23703645) Transpl Infect Dis. 2002 Sep;4(3):144-7. (PMID: 12421459) Transplantation. 2021 Jul 1;105(7):1492-1501. (PMID: 33044431) Can J Kidney Health Dis. 2022 Jul 21;9:20543581221111712. (PMID: 35898578) AIDS. 2016 Jan 28;30(3):435-44. (PMID: 26765937) Kidney360. 2020 Jan 16;1(2):115-118. (PMID: 35372909) PLoS One. 2011;6(6):e21748. (PMID: 21738786) Kidney Int. 2015 Aug;88(2):341-9. (PMID: 25807035) J Am Soc Nephrol. 2002 Jul;13(7):1889-93. (PMID: 12089385) Ann Surg. 2017 Mar;265(3):604-608. (PMID: 27768622) PLoS Med. 2015 Oct 06;12(10):e1001885. (PMID: 26440803) Nephrol Dial Transplant. 2014 Jun;29(6):1232-8. (PMID: 23975841) J Int Assoc Provid AIDS Care. 2022 Jan-Dec;21:23259582221089194. (PMID: 35369795) Int J Environ Res Public Health. 2022 Oct 01;19(19):. (PMID: 36231850) Nephrol Dial Transplant. 2015 Oct;30(10):1734-40. (PMID: 26175146) |
| فهرسة مساهمة: | Keywords: HIV infection; death; end stage kidney disease; graft failure; kidney transplantation |
| تواريخ الأحداث: | Date Created: 20240513 Latest Revision: 20240514 |
| رمز التحديث: | 20240514 |
| مُعرف محوري في PubMed: | PMC11083635 |
| DOI: | 10.1093/ofid/ofae182 |
| PMID: | 38737424 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2328-8957 |
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| DOI: | 10.1093/ofid/ofae182 |