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Intermittent theta-burst stimulation to the right dorsolateral prefrontal cortex may increase potentiated startle in healthy individuals.

التفاصيل البيبلوغرافية
العنوان: Intermittent theta-burst stimulation to the right dorsolateral prefrontal cortex may increase potentiated startle in healthy individuals.
المؤلفون: Teferi M; Center for Neuromodulation in Depression and Stress Department of Psychiatry University of Pennsylvania, Philadelphia, PA, USA., Gura H; Center for Neuromodulation in Depression and Stress Department of Psychiatry University of Pennsylvania, Philadelphia, PA, USA.; Neuroscience Graduate Group Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, USA., Patel M; Center for Neuromodulation in Depression and Stress Department of Psychiatry University of Pennsylvania, Philadelphia, PA, USA., Casalvera A; Center for Neuromodulation in Depression and Stress Department of Psychiatry University of Pennsylvania, Philadelphia, PA, USA., Lynch KG; Department of Psychiatry University of Pennsylvania, Philadelphia, PA, USA., Makhoul W; Center for Neuromodulation in Depression and Stress Department of Psychiatry University of Pennsylvania, Philadelphia, PA, USA., Deng ZD; Noninvasive Neuromodulation Unit Experimental Therapeutics and Pathophysiology Branch National Institute of Mental Health National Institutes of Health Bethesda, Bethesda, MD, USA., Oathes DJ; Center for Neuromodulation in Depression and Stress Department of Psychiatry University of Pennsylvania, Philadelphia, PA, USA.; Center for Brain Imaging and Stimulation Department of Psychiatry University of Pennsylvania, Philadelphia, PA, USA.; Penn Brain Science, Translation, Innovation, and Modulation Center University of Pennsylvania, Philadelphia, PA, USA., Sheline YI; Center for Neuromodulation in Depression and Stress Department of Psychiatry University of Pennsylvania, Philadelphia, PA, USA., Balderston NL; Center for Neuromodulation in Depression and Stress Department of Psychiatry University of Pennsylvania, Philadelphia, PA, USA. nicholas.balderston@pennmedicine.upenn.edu.; Center for Brain Imaging and Stimulation Department of Psychiatry University of Pennsylvania, Philadelphia, PA, USA. nicholas.balderston@pennmedicine.upenn.edu.; Penn Brain Science, Translation, Innovation, and Modulation Center University of Pennsylvania, Philadelphia, PA, USA. nicholas.balderston@pennmedicine.upenn.edu.
المصدر: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 Sep; Vol. 49 (10), pp. 1619-1629. Date of Electronic Publication: 2024 May 13.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
أسماء مطبوعة: Publication: 2003- : London : Nature Publishing Group
Original Publication: [New York, NY] : Elsevier, [c1987-
مواضيع طبية MeSH: Reflex, Startle*/physiology , Transcranial Magnetic Stimulation*/methods , Cross-Over Studies* , Dorsolateral Prefrontal Cortex*/physiology , Theta Rhythm*/physiology, Humans ; Male ; Female ; Adult ; Double-Blind Method ; Young Adult ; Anxiety/physiopathology ; Anxiety/therapy ; Prefrontal Cortex/physiology ; Functional Laterality/physiology ; Healthy Volunteers
مستخلص: Repetitive transcranial magnetic stimulation (rTMS) treatment protocols targeting the right dlPFC have been effective in reducing anxiety symptoms comorbid with depression. However, the mechanism behind these effects is unclear. Further, it is unclear whether these results generalize to non-depressed individuals. We conducted a series of studies aimed at understanding the link between anxiety potentiated startle and the right dlPFC, following a previous study suggesting that continuous theta burst stimulation (cTBS) to the right dlPFC can make people more anxious. Based on these results we hypothesized that intermittent TBS (iTBS), which is thought to have opposing effects on plasticity, may reduce anxiety when targeted at the same right dlPFC region. In this double-blinded, cross-over design, 28 healthy subjects underwent 12 study visits over a 4-week period. During each of their 2 stimulation weeks, they received four 600 pulse iTBS sessions (2/day), with a post-stimulation testing session occurring 24 h following the final iTBS session. One week they received active stimulation, one week they received sham. Stimulation weeks were separated by a 1-week washout period and the order of active/sham delivery was counterbalanced across subjects. During the testing session, we induced anxiety using the threat of unpredictable shock and measured anxiety potentiated startle. Contrary to our initial hypothesis, subjects showed increased startle reactivity following active compared to sham stimulation. These results replicate work from our two previous trials suggesting that TMS to the right dlPFC increases anxiety potentiated startle, independent of both the pattern of stimulation and the timing of the post stimulation measure. Although these results confirm a mechanistic link between right dlPFC excitability and startle, capitalizing upon this link for the benefit of patients will require future exploration.
(© 2024. The Author(s).)
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معلومات مُعتمدة: K01 MH121777 United States MH NIMH NIH HHS; K01MH121777 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH); Narsad 2021 Brain and Behavior Research Foundation (Brain & Behavior Research Foundation); Narsad 2018 Brain and Behavior Research Foundation (Brain & Behavior Research Foundation)
تواريخ الأحداث: Date Created: 20240513 Date Completed: 20240812 Latest Revision: 20240815
رمز التحديث: 20240815
مُعرف محوري في PubMed: PMC11319663
DOI: 10.1038/s41386-024-01871-w
PMID: 38740902
قاعدة البيانات: MEDLINE
الوصف
تدمد:1740-634X
DOI:10.1038/s41386-024-01871-w