دورية أكاديمية
Common alterations in parallel metabolomic profiling of serum and spinal cord and mechanistic studies on neuropathic pain following PPARα administration.
| العنوان: | Common alterations in parallel metabolomic profiling of serum and spinal cord and mechanistic studies on neuropathic pain following PPARα administration. |
|---|---|
| المؤلفون: | Zhao YY; Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, 300052, China; Tianjin Research Institute of Anesthesiology, Tianjin, 300052, China., Wu ZJ; Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, 300052, China; Tianjin Research Institute of Anesthesiology, Tianjin, 300052, China., Hao SJ; Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, 300052, China; Tianjin Research Institute of Anesthesiology, Tianjin, 300052, China., Dong BB; Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, 300052, China; Tianjin Research Institute of Anesthesiology, Tianjin, 300052, China., Zheng YX; Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, 300052, China; Tianjin Research Institute of Anesthesiology, Tianjin, 300052, China., Liu B; Department of Critical Care Medicine, General Hospital of Tianjin Medical University, Tianjin, 300052, China; Center for Critical Care Medicine, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, 300020, China. Electronic address: liubin78@163.com., Li J; Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, 300052, China; Tianjin Research Institute of Anesthesiology, Tianjin, 300052, China. Electronic address: xtjing@163.com. |
| المصدر: | Neuropharmacology [Neuropharmacology] 2024 Aug 15; Vol. 254, pp. 109988. Date of Electronic Publication: 2024 May 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Pergamon Press Original Publication: Oxford, New York, Pergamon. |
| مواضيع طبية MeSH: | PPAR alpha*/metabolism , Neuralgia*/drug therapy , Neuralgia*/metabolism , Spinal Cord*/metabolism , Spinal Cord*/drug effects , Mice, Inbred C57BL*, Animals ; Male ; Mice ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Metabolomics ; Microglia/drug effects ; Microglia/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors ; Neuroinflammatory Diseases/drug therapy ; Neuroinflammatory Diseases/metabolism ; Dendritic Spines/drug effects ; Dendritic Spines/metabolism ; Dendritic Spines/pathology ; Inflammasomes/metabolism ; Inflammasomes/drug effects |
| مستخلص: | Neuropathic pain (NP) is usually treated with analgesics and symptomatic therapy with poor efficacy and numerous side effects, highlighting the urgent need for effective treatment strategies. Recent studies have reported an important role for peroxisome proliferator-activated receptor alpha (PPARα) in regulating metabolism as well as inflammatory responses. Through pain behavioral assessment, we found that activation of PPARα prevented chronic constriction injury (CCI)-induced mechanical allodynia and thermal hyperalgesia. In addition, PPARα ameliorated inflammatory cell infiltration at the injury site and decreased microglial activation, NOD-like receptor protein 3 (NLRP3) inflammasome production, and spinal dendritic spine density, as well as improved serum and spinal cord metabolic levels in mice. Administration of PPARα antagonists eliminates the analgesic effect of PPARα agonists. PPARα relieves NP by inhibiting neuroinflammation and functional synaptic plasticity as well as modulating metabolic mechanisms, suggesting that PPARα may be a potential molecular target for NP alleviation. However, the effects of PPARα on neuroinflammation and synaptic plasticity should be further explored. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Metabolism; NLRP3; Neuroinflammation; Neuropathic pain; PPARα |
| المشرفين على المادة: | 0 (PPAR alpha) 0 (Ppara protein, mouse) 0 (NLR Family, Pyrin Domain-Containing 3 Protein) 0 (Nlrp3 protein, mouse) 0 (Inflammasomes) |
| تواريخ الأحداث: | Date Created: 20240514 Date Completed: 20240601 Latest Revision: 20240610 |
| رمز التحديث: | 20240610 |
| DOI: | 10.1016/j.neuropharm.2024.109988 |
| PMID: | 38744401 |
| قاعدة البيانات: | MEDLINE |
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