التفاصيل البيبلوغرافية
| العنوان: |
Acetylcholine demixes heterogeneous dopamine signals for learning and moving. |
| المؤلفون: |
Jang HJ, Ward RM, Golden CEM, Constantinople CM |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 May 04. Date of Electronic Publication: 2024 May 04. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
Midbrain dopamine neurons promote reinforcement learning and movement vigor. A major outstanding question is how dopamine-recipient neurons in the striatum parse these heterogeneous signals. Here we characterized dopamine and acetylcholine release in the dorsomedial striatum (DMS) of rats performing a decision-making task. We found that dopamine acted as a reward prediction error (RPE), modulating behavior and DMS spiking on subsequent trials when coincident with pauses in cholinergic release. In contrast, at task events that elicited coincident bursts of acetylcholine and dopamine, dopamine preceded contralateral movements and predicted movement vigor without inducing plastic changes in DMS firing rates. Our findings provide a circuit-level mechanism by which cholinergic modulation allows the same dopamine signals to be used for either movement or learning depending on instantaneous behavioral context. |
| معلومات مُعتمدة: |
DP2 MH126376 United States MH NIMH NIH HHS |
| تواريخ الأحداث: |
Date Created: 20240515 Latest Revision: 20240904 |
| رمز التحديث: |
20240904 |
| مُعرف محوري في PubMed: |
PMC11092744 |
| DOI: |
10.1101/2024.05.03.592444 |
| PMID: |
38746300 |
| قاعدة البيانات: |
MEDLINE |
