دورية أكاديمية
Characterization of a novel adipose tissue located between abdominal lymph nodes and cervix/prostate in mice.
| العنوان: | Characterization of a novel adipose tissue located between abdominal lymph nodes and cervix/prostate in mice. |
|---|---|
| المؤلفون: | Hu L; Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, People's Republic of China.; Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China., Zhang G; Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, People's Republic of China.; Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China., Tong X; Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Institute of Brain Science, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan Institutes of Integrative Medicine, Fudan University, Shanghai, People's Republic of China., Wang L; Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, People's Republic of China.; Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China., Qiu X; Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, People's Republic of China.; Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China., Yang H; Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, People's Republic of China.; Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China., Liu X; Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, People's Republic of China.; Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China., Huang H; Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, People's Republic of China.; Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China.; Key Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China. |
| المصدر: | American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2024 Jul 01; Vol. 327 (1), pp. E134-E144. Date of Electronic Publication: 2024 May 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, MD. : American Physiological Society |
| مواضيع طبية MeSH: | Lymph Nodes*/metabolism , Uncoupling Protein 1*/metabolism , Uncoupling Protein 1*/genetics , Adipose Tissue, Brown*/metabolism , Cervix Uteri*/metabolism , Prostate*/metabolism, Animals ; Male ; Female ; Mice ; Pregnancy ; Adipose Tissue, White/metabolism ; Mice, Inbred C57BL ; Adipose Tissue/metabolism ; Androgens/pharmacology ; Androgens/metabolism ; Sexual Behavior, Animal/physiology |
| مستخلص: | Perigonadal adipose tissue is a homogeneous white adipose tissue (WAT) in adult male mice without any brown adipose tissue (BAT). However, there are congenital differences in the gonads between male and female mice. Whether heterogeneity existed in perigonadal adipose tissues (ATs) in female mice remains unknown. This study reported a perigonadal brown-like AT located between abdominal lymph nodes and the uterine cervix in female mice, termed lymph node-cervical adipose tissue (LNCAT). Its counterpart, lymph node-prostatic adipose tissue (LNPAT), exhibited white phenotype in adult virgin male mice. When exposed to cold, LNCAT/LNPAT increased uncoupling protein 1 (UCP1) expression via activation of tyrosine hydroxylase (TH), in which abdominal lymph nodes were involved. Interestingly, the UCP1 expression in LNCAT/LNPAT varied under different reproductive stages. The UCP1 expression in LNCAT was upregulated at early pregnancy, declined at midlate pregnancy, and reverted in weaning dams. Mating behavior stimulated LNPAT browning in male mice. We found that androgen but not estrogen or progesterone inhibited UCP1 expression in LNCAT. Androgen administration reversed the castration-induced LNPAT browning. Our results identified a perigonadal brown-like AT in female mice and characterized its UCP1 expression patterns under various conditions. NEW & NOTEWORTHY A novel perigonadal brown-like AT (LNCAT) of female mice was identified. Abdominal lymph nodes were involved in cold-induced browning in this newly discovered adipose tissue. The UCP1 expression in LNCAT/LNPAT was also related to ages, sexes, and reproductive stages, in which androgen acted as an inhibitor role. |
| معلومات مُعتمدة: | 82088102 MOST | National Natural Science Foundation of China (NSFC); 2019-I2M-5-064 CAMS Innovation Funding For Medical Science; 2020CXJQ01 Collaborative Innovation Program of Shanghai Municipal Health Commission; GWVI-11.1-35 Key Discipline Construction Project (2023-2025) of Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai; SHDC2020CR1008A Clinical Research Plan of SHDC; 22MC1940200 Shanghai Clinical Research Center for Gynecological Disease; 2022ZZ01012 Shanghai Urogenitial System Diseases Research Center; Shanghai Frontiers Science Research Center of Reproduction and Develpoment |
| فهرسة مساهمة: | Keywords: androgen; brown adipose tissue; perigonadal adipose tissue; sex hormone; uncoupling protein 1 |
| المشرفين على المادة: | 0 (Uncoupling Protein 1) 0 (Ucp1 protein, mouse) 0 (Androgens) |
| تواريخ الأحداث: | Date Created: 20240515 Date Completed: 20240717 Latest Revision: 20240717 |
| رمز التحديث: | 20240718 |
| DOI: | 10.1152/ajpendo.00110.2024 |
| PMID: | 38747899 |
| قاعدة البيانات: | MEDLINE |
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