دورية أكاديمية
Multimodal Structural and Functional Characterization of Retinal Vasculopathy with Cerebral Leukoencephalopathy.
| العنوان: | Multimodal Structural and Functional Characterization of Retinal Vasculopathy with Cerebral Leukoencephalopathy. |
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| المؤلفون: | Wang WX; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri., Shah AV; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri., Bruck B; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri., Van Stavern G; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri., Rao PK; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri., Apte RS; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri. Electronic address: apte@wustl.edu. |
| المصدر: | Ophthalmology. Retina [Ophthalmol Retina] 2024 Apr; Vol. 8 (4), pp. 331-339. Date of Electronic Publication: 2023 Oct 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published by Elsevier Inc. on behalf of American Academy of Ophthalmology Country of Publication: United States NLM ID: 101695048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-6530 (Electronic) Linking ISSN: 24686530 NLM ISO Abbreviation: Ophthalmol Retina Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Published by Elsevier Inc. on behalf of American Academy of Ophthalmology, [2017]- |
| مواضيع طبية MeSH: | Tomography, Optical Coherence*/methods , Fluorescein Angiography*/methods , Visual Acuity* , Electroretinography*/methods , Multimodal Imaging* , Leukoencephalopathies*/diagnosis , Leukoencephalopathies*/physiopathology, Humans ; Male ; Female ; Cross-Sectional Studies ; Adult ; Middle Aged ; Visual Fields/physiology ; Retinal Diseases/diagnosis ; Retinal Diseases/physiopathology ; Retinal Diseases/etiology ; Retinal Vessels/diagnostic imaging ; Retinal Vessels/physiopathology ; Retinal Vessels/pathology ; Young Adult ; Fundus Oculi ; Adolescent |
| مستخلص: | Objective: To describe and quantify the structural and functional consequences of retinal vasculopathy with cerebral leukoencephalopathy (RVCL) on the neurosensory retina. Design: Cross sectional descriptive study from December 2021 to December 2022. Participants: Retinal vasculopathy with cerebral leukoencephalopathy patients (n = 9, 18 eyes) recruited from the RVCL Research Center at Washington University in St. Louis. Methods: Retinal vasculopathy with cerebral leukoencephalopathy patients underwent comprehensive ophthalmological evaluation including OCT, OCT angiography (OCTA), ultrawidefield fundus imaging, retinal autofluorescence, dark adaptation, electroretinography (ERG), Goldmann kinetic perimetry, and fluorescein angiography (FA). Main Outcome Measures: Comprehensive characterization from various modalities including best-corrected visual acuity, central subfield thickness (μm) from OCT, foveal avascular zone (mm 2 ) from OCTA, dark adaptation rod intercept (seconds), cone response in ERG, and presence or absence of vascular abnormalities, leakage, neovascularization, and nonperfusion on FA. Results: A total of 18 eyes from 9 individuals were included in this study. The best-corrected visual acuity ranged from 20/15 to 20/70. The mean central subfield thickness from OCT was 275.8 μm (range, 217-488 μm). The mean foveal avascular zone (FAZ) from OCTA was 0.65 (range, 0.18-1.76) mm 2 . On dark adaptometry, the mean time was 5.02 (range, 2.9-6.5) minutes, and 1 individual had impaired dark adaptation. Electroretinography demonstrated mild cone response impairment in 4 eyes. On FA, there was evidence of macular and peripheral capillary nonperfusion in 16 of 18 eyes and notable areas of vascular leakage and retinal edema in 5 of the 18 eyes. Conclusions: This study illustrates the phenotypic spectrum of disease and may be clinically valuable for aiding diagnosis, monitoring disease progression, and further elucidating the pathophysiology of RVCL to aid in the development of therapies. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. (Copyright © 2023 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: FA; Multimodal characterization; OCT; OCT-A; Retinal vasculopathy with cerebral leukoencephalopathy |
| تواريخ الأحداث: | Date Created: 20240516 Date Completed: 20240516 Latest Revision: 20240516 |
| رمز التحديث: | 20240516 |
| DOI: | 10.1016/j.oret.2023.10.013 |
| PMID: | 38752998 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2468-6530 |
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| DOI: | 10.1016/j.oret.2023.10.013 |