دورية أكاديمية
أعرض في EDS

Lipid and hemolysis parameters predicting acute chest syndrome in adulthood with sickle cell disease.

التفاصيل البيبلوغرافية
العنوان: Lipid and hemolysis parameters predicting acute chest syndrome in adulthood with sickle cell disease.
المؤلفون: Feugray G; Department of General Biochemistry, Normandie Univ, UNIROUEN, INSERM U1096 EnVI, CHU Rouen, Rouen, F-76000, France. guillaume.feugray@chu-rouen.fr.; Service de Biochimie, Centre hospitalier Universitaire Charles Nicolle, 1 rue de Germont, Rouen, 76031, France. guillaume.feugray@chu-rouen.fr., Grall M; Department of Internal Medicine, CHU Rouen, Rouen, F-76000, France., Dumesnil C; Department of Pediatric Onco-Hematology, CHU Rouen, Rouen, F-76000, France., Brunel V; Department of General Biochemistry, CHU Rouen, Rouen, F-76000, France., Benhamou Y; Department of Internal Medicine, Normandie Univ, UNIROUEN, INSERM U1096, CHU Rouen, Rouen, F-76000, France., Quillard Muraine M; Department of General Biochemistry, Normandie Univ, UNIROUEN, INSERM U1404 INSERMU1073 ADEN, CHU Rouen, CIC-CRB, Rouen, F-76000, France., Billoir P; Normandie Univ, UNIROUEN, INSERM U1096 EnVI, CHU Rouen, Vascular Hemostasis Unit, Rouen, F-76000, France.
المصدر: Lipids in health and disease [Lipids Health Dis] 2024 May 16; Vol. 23 (1), pp. 140. Date of Electronic Publication: 2024 May 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101147696 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-511X (Electronic) Linking ISSN: 1476511X NLM ISO Abbreviation: Lipids Health Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2002-
مواضيع طبية MeSH: Anemia, Sickle Cell*/blood , Anemia, Sickle Cell*/complications , Acute Chest Syndrome*/blood , Acute Chest Syndrome*/etiology , Hemolysis*, Humans ; Male ; Female ; Adult ; Cholesterol, LDL/blood ; Middle Aged ; Triglycerides/blood ; Cholesterol, HDL/blood ; Bilirubin/blood ; Lipids/blood
مستخلص: Sickle cell disease (SCD) is a lifelong blood disorder affecting approximately 100,000 people in the United States and is one of the most common monogenic diseases. A serious complication of SCD is acute chest syndrome (ACS). ACS is a condition with a high rate of morbidity and mortality. The aim of the study was to assess hemolysis and lipid parameters in a cohort of confirmed SCD patients to predict ACS development in the following year.Standard lipid were performed (triglycerides, total cholesterol, high-density cholesterol, low-density cholesterol) panel to calculate of non-HDL-C, large buoyant LDL cholesterol (lbLDL-C) and small dense LDL cholesterol (sdLDL-C) with Sampson equation. Hemolysis and hematologic parameters were also evaluated.Among 91 patients included between September 2018 and June 2021, thirty-seven patients had history of ACS and 6 patients developed ACS during following year. In unadjusted logistic regression, total bilirubin was associated with ACS occurrence (RR: 1.2 [1.05-1.51] p = 0.013). Concerning lipid profile, non-HDL-C (RR: 0.87 [0.0.67-0.99] p = 0.04) and sdLDL-C (RR: 0.78 [0.49-0.96] p = 0.03) were associated with ACS occurrence decrease. C-reactive protein was associated with ACS occurrence (RR: 1.27 [1.065-1.85] p = 0.011).Based on these findings, this study demonstrated that several biomarker easily available can be used at steady state to predict ACS in the following year. The validation of these results are required to ensure the reproducibility of the findings.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Acute chest syndrome; Hemolysis; Inflammatory; Lipid parameters; Sickle cell disease
تواريخ الأحداث: Date Created: 20240516 Date Completed: 20240517 Latest Revision: 20240519
رمز التحديث: 20240519
مُعرف محوري في PubMed: PMC11100209
DOI: 10.1186/s12944-024-02135-8
PMID: 38755670
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-511X
DOI:10.1186/s12944-024-02135-8