دورية أكاديمية
أعرض في EDS

LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa.

التفاصيل البيبلوغرافية
العنوان: LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa.
المؤلفون: De Felice B; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, I-81100 Caserta, Italy., De Luca P; Anton Dohrn Naples Zoological Station, I-80121 Naples, Italy., Montanino C; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, I-81100 Caserta, Italy., Mallardo M; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, I-81100 Caserta, Italy., Babino G; Dermatology Unit, University of Campania Luigi Vanvitelli, I-80131 Naples, Italy., Mattera E; Department of Internal and Experimental Medicine and Surgery Unit of Internal Medicine, University of Campania Luigi Vanvitelli, I-80131 Naples, Italy., Sorbo R; Department of Internal and Experimental Medicine and Surgery Unit of Internal Medicine, University of Campania Luigi Vanvitelli, I-80131 Naples, Italy., Ragozzino G; Department of Internal and Experimental Medicine and Surgery Unit of Internal Medicine, University of Campania Luigi Vanvitelli, I-80131 Naples, Italy., Argenziano G; Dermatology Unit, University of Campania Luigi Vanvitelli, I-80131 Naples, Italy., Daniele A; CEINGE‑Franco Salvatore Advanced Biotechnology, I-80145 Naples, Italy., Nigro E; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, I-81100 Caserta, Italy.
المصدر: Molecular medicine reports [Mol Med Rep] 2024 Jul; Vol. 30 (1). Date of Electronic Publication: 2024 May 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Athens, Greece : D. A. Spandidos
مواضيع طبية MeSH: Hidradenitis Suppurativa*/genetics , Hidradenitis Suppurativa*/blood , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/blood , Gene Expression Profiling* , Gene Regulatory Networks*, Humans ; Male ; Adult ; Female ; MicroRNAs/genetics ; MicroRNAs/blood ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Middle Aged ; Gene Expression Regulation
مستخلص: Long noncoding RNAs (lncRNAs) have been demonstrated to be involved in biological processes, both physiological and pathological, including cancer, cardiovascular diseases, multiple sclerosis, autoimmune hepatitis and types I and II diabetes. LncRNAs are also known to have a critical role in the physiology of skin, and in the pathology of cutaneous diseases. LncRNAs are involved in a wide range of biological activities, including transcriptional post‑transcriptional processes, epigenetics, RNA splicing, gene activation and or silencing, modifications and/or editing; therefore, lncRNAs may be useful as potential targets for disease treatment. Hidradenitis suppurativa (HS), also termed acne inversa, is a major skin disease, being an inflammatory disorder that affects ~1% of global population in a chronic manner. Its pathogenesis, however, is only partly understood, although immune dysregulation is known to have an important role. To investigate the biological relevance of lncRNAs with HS, the most differentially expressed lncRNAs and mRNAs were first compared. Furthermore, the lncRNA‑microRNA regulatory network was also defined via reverse transcription‑quantitative PCR analysis, whereby a trio of lncRNA expression signatures, lncRNA‑TINCR, lncRNA‑RBM5‑ASI1 and lncRNA‑MRPL23‑AS1, were found to be significantly overexpressed in patients with HS compared with healthy controls. In conclusion, the three lncRNAs isolated in the present study may be useful for improving the prognostic prediction of HS, as well as contributing towards an improved understanding of the underlying pathogenic mechanisms, thereby potentially providing new therapeutic targets.
References: Cell Mol Life Sci. 2016 Jul;73(13):2491-509. (PMID: 27007508)
Cytoskeleton (Hoboken). 2023 Jul-Aug;80(7-8):228-241. (PMID: 36205643)
Genes (Basel). 2022 Aug 26;13(9):. (PMID: 36140712)
PLoS One. 2010 Nov 02;5(11):e13799. (PMID: 21082023)
Genes (Basel). 2021 Jun 11;12(6):. (PMID: 34208031)
Ther Adv Med Oncol. 2022 Aug 12;14:17588359221118010. (PMID: 35983027)
Front Immunol. 2021 Dec 08;12:770679. (PMID: 34956196)
Front Med (Lausanne). 2023 Apr 18;10:1165098. (PMID: 37144036)
Int J Mol Sci. 2020 Feb 04;21(3):. (PMID: 32033158)
Int J Mol Sci. 2022 Jul 28;23(15):. (PMID: 35955480)
J Biol Chem. 2019 Nov 15;294(46):17693-17706. (PMID: 31594864)
Dermatology. 2022;238(3):487-497. (PMID: 34474409)
Chin J Physiol. 2021 Nov-Dec;64(6):257-265. (PMID: 34975118)
Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
Front Med (Lausanne). 2017 Jul 24;4:119. (PMID: 28791291)
Elife. 2022 Aug 05;11:. (PMID: 35929607)
PLoS One. 2012;7(8):e42377. (PMID: 22879955)
Cold Spring Harb Perspect Med. 2014 May 01;4(5):. (PMID: 24789873)
Int J Mol Sci. 2022 Feb 14;23(4):. (PMID: 35216228)
Nat Rev Mol Cell Biol. 2023 Jun;24(6):430-447. (PMID: 36596869)
Dermatol Ther (Heidelb). 2023 Feb;13(2):581-594. (PMID: 36585607)
Nat Rev Cardiol. 2015 Jul;12(7):415-25. (PMID: 25855606)
Biostat Bioinforma Biomath. 2013 Aug;3(3):71-85. (PMID: 25558171)
Biomolecules. 2022 Dec 02;12(12):. (PMID: 36551230)
Dermatol Pract Concept. 2022 Oct 01;12(4):e2022157. (PMID: 36534576)
Biomed Rep. 2021 Oct;15(4):85. (PMID: 34512973)
Front Immunol. 2021 Nov 29;12:773171. (PMID: 34912342)
Int J Mol Sci. 2021 Dec 17;22(24):. (PMID: 34948375)
Hepatobiliary Pancreat Dis Int. 2023 Apr;22(2):128-139. (PMID: 36543619)
Front Endocrinol (Lausanne). 2022 Jan 10;12:690555. (PMID: 35082751)
Cells. 2021 Aug 15;10(8):. (PMID: 34440863)
Front Cell Dev Biol. 2017 Feb 07;5:3. (PMID: 28224124)
Mol Cell. 2022 Jun 16;82(12):2252-2266. (PMID: 35714586)
فهرسة مساهمة: Keywords: RT‑qPCR; gene regulation; hidradenitis suppurativa; long noncoding RNAs; microRNAs
تواريخ الأحداث: Date Created: 20240517 Date Completed: 20240517 Latest Revision: 20240519
رمز التحديث: 20240519
مُعرف محوري في PubMed: PMC11094584
DOI: 10.3892/mmr.2024.13236
PMID: 38757342
قاعدة البيانات: MEDLINE
الوصف
تدمد:1791-3004
DOI:10.3892/mmr.2024.13236