دورية أكاديمية
Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion.
| العنوان: | Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion. |
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| المؤلفون: | Kim JH; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota.; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida.; University of Florida Health Cancer Center, University of Florida, Gainesville, Florida.; Intelligent Critical Care Center, University of Florida, Gainesville, Florida.; Artificial Intelligence Academic Initiative (AI2) Center, University of Florida, Gainesville, Florida., Schulte AJ; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota.; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Sarver AL; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota., Lee D; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida., Angelos MG; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota.; Department of Medicine (Division of Hematology, Oncology, and Transplantation), Medical School, University of Minnesota, Minneapolis, Minnesota.; Microbiology, Immunology and Cancer Biology (MICaB) Graduate Program, University of Minnesota, Minneapolis, Minnesota.; Department of Medicine, Division of Hematology and Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Frantz AM; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota.; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Capstan Therapeutics, San Diego, California., Forster CL; The University of Minnesota Biological Materials Procurement Network (BioNet), University of Minnesota, Minneapolis, Minnesota., O'Brien TD; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota.; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota., Cornax I; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.; Janssen Research and Development, LLC., O'Sullivan MG; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota., Cheng N; School of Mathematics, College of Science and Engineering, University of Minnesota, Minneapolis, Minnesota.; Applied Mathematics, University of Colorado Boulder, Boulder, Colorado., Lewellen M; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota.; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Oseth L; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Kumar S; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota., Bullman S; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Pedamallu CS; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Goyal SM; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota., Meyerson M; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Lund TC; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota., Breen M; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina.; Cancer Genetics Program, University of North Carolina Lineberger Comprehensive Cancer Center, Raleigh, North Carolina., Lindblad-Toh K; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Science of Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden., Dickerson EB; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota.; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Kaufman DS; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota.; Department of Medicine (Division of Hematology, Oncology, and Transplantation), Medical School, University of Minnesota, Minneapolis, Minnesota.; Center for Immunology, University of Minnesota, Minneapolis, Minnesota.; Division of Regenerative Medicine, Department of Medicine, University of California-San Diego, La Jolla, California., Modiano JF; Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota.; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota.; Center for Immunology, University of Minnesota, Minneapolis, Minnesota.; Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, Minnesota.; Center for Engineering in Medicine, University of Minnesota, Minneapolis, Minnesota. |
| المصدر: | Cancer research communications [Cancer Res Commun] 2024 Jun 11; Vol. 4 (6), pp. 1467-1480. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Philadelphia, Pennsylvania] : American Association for Cancer Research, [2021]- |
| مواضيع طبية MeSH: | Hemangiosarcoma*/pathology , Hemangiosarcoma*/veterinary , Hemangiosarcoma*/genetics, Dogs ; Animals ; Humans ; Mice ; Tumor Microenvironment ; Hematopoietic Stem Cells/pathology ; Hematopoiesis ; Cell Differentiation |
| مستخلص: | Hemangiosarcoma and angiosarcoma are soft-tissue sarcomas of blood vessel-forming cells in dogs and humans, respectively. These vasoformative sarcomas are aggressive and highly metastatic, with disorganized, irregular blood-filled vascular spaces. Our objective was to define molecular programs which support the niche that enables progression of canine hemangiosarcoma and human angiosarcoma. Dog-in-mouse hemangiosarcoma xenografts recapitulated the vasoformative and highly angiogenic morphology and molecular characteristics of primary tumors. Blood vessels in the tumors were complex and disorganized, and they were lined by both donor and host cells. In a series of xenografts, we observed that the transplanted hemangiosarcoma cells created exuberant myeloid hyperplasia and gave rise to lymphoproliferative tumors of mouse origin. Our functional analyses indicate that hemangiosarcoma cells generate a microenvironment that supports expansion and differentiation of hematopoietic progenitor populations. Furthermore, gene expression profiling data revealed hemangiosarcoma cells expressed a repertoire of hematopoietic cytokines capable of regulating the surrounding stromal cells. We conclude that canine hemangiosarcomas, and possibly human angiosarcomas, maintain molecular properties that provide hematopoietic support and facilitate stromal reactions, suggesting their potential involvement in promoting the growth of hematopoietic tumors. Significance: We demonstrate that hemangiosarcomas regulate molecular programs supporting hematopoietic expansion and differentiation, providing insights into their potential roles in creating a permissive stromal-immune environment for tumor progression. (© 2024 The Authors; Published by the American Association for Cancer Research.) |
| معلومات مُعتمدة: | P30 CA077598 United States CA NCI NIH HHS; R03 CA191713 United States CA NCI NIH HHS; R50 CA211249 United States CA NCI NIH HHS; 1R03CA191713-01 HHS | NIH | National Cancer Institute (NCI); #02759 American Kennel Club Canine Health Foundation (CHF); #422 American Kennel Club Canine Health Foundation (CHF); 1889-G American Kennel Club Canine Health Foundation (CHF); JHK15MN-004 National Canine Cancer Foundation (NCCF); D10-501 Morris Animal Foundation (MAF); n/a Cancerfonden (Swedish Cancer Society); CA211249 HHS | NIH | National Cancer Institute (NCI); P30 CA077598 United States CA NCI NIH HHS; CA191225 U.S. Department of Defense (DOD) |
| تواريخ الأحداث: | Date Created: 20240517 Date Completed: 20240613 Latest Revision: 20240613 |
| رمز التحديث: | 20240613 |
| مُعرف محوري في PubMed: | PMC11166094 |
| DOI: | 10.1158/2767-9764.CRC-23-0441 |
| PMID: | 38757809 |
| قاعدة البيانات: | MEDLINE |
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