دورية أكاديمية
أعرض في EDS

The impact of biomolecule interactions on the cytotoxic effects of rhenium(I) tricarbonyl complexes.

التفاصيل البيبلوغرافية
العنوان: The impact of biomolecule interactions on the cytotoxic effects of rhenium(I) tricarbonyl complexes.
المؤلفون: de Lavor TS; Laboratório Interdisciplinar de Fototerapia e Biomoléculas (LIFeBio), Instituto de Química (IQ), Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., Teixeira MHS; Laboratório de Citogenética, Instituto de Biotecnologia (IBTEC), Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., de Matos PA; Laboratório Interdisciplinar de Fototerapia e Biomoléculas (LIFeBio), Instituto de Química (IQ), Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., Lino RC; Laboratório de Citogenética, Instituto de Biotecnologia (IBTEC), Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., Silva CMF; Laboratório de Citogenética, Instituto de Biotecnologia (IBTEC), Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., do Carmo MEG; Laboratory of Photochemistry and Materials Science, Chemistry Institute, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil., Beletti ME; Instituto de Ciências Biomédicas (ICBIM), Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., Patrocinio AOT; Laboratory of Photochemistry and Materials Science, Chemistry Institute, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil., de Oliveira Júnior RJ; Laboratório de Citogenética, Instituto de Biotecnologia (IBTEC), Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil. Electronic address: oliveirajunior@ufu.br., Tsubone TM; Laboratório Interdisciplinar de Fototerapia e Biomoléculas (LIFeBio), Instituto de Química (IQ), Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil. Electronic address: tayana.tsubone@ufu.br.
المصدر: Journal of inorganic biochemistry [J Inorg Biochem] 2024 Aug; Vol. 257, pp. 112600. Date of Electronic Publication: 2024 May 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, Elsevier.
مواضيع طبية MeSH: Rhenium*/chemistry , Coordination Complexes*/pharmacology , Coordination Complexes*/chemistry , Coordination Complexes*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , DNA*/chemistry , DNA*/metabolism, Humans ; Phenanthrolines/chemistry ; Phenanthrolines/pharmacology ; Quinoxalines/chemistry ; Quinoxalines/pharmacology ; Phenazines/chemistry ; Phenazines/pharmacology ; Cell Line, Tumor ; HeLa Cells
مستخلص: Rhenium complexes show great promise as anticancer drug candidates. Specifically, compounds with a Re(CO) 3 (NN)(py) + core in their architecture have shown cytotoxicity equal to or greater than that of well-established anticancer drugs based on platinum or organic molecules. This study aimed to evaluate how the strength of the interaction between rhenium(I) tricarbonyl complexes fac-[Re(CO) 3 (NN)(py)] + , NN = 1,10-phenanthroline (phen), dipyrido[3,2-f:2',3'-h]quinoxaline (dpq) or dipyrido[3,2-a:2'3'-c]phenazine (dppz) and biomolecules (protein, lipid and DNA) impacted the corresponding cytotoxic effect in cells. Results showed that fac-[Re(CO) 3 (dppz)(py)] + has higher Log P o/w and binding constant (K b ) with biomolecules (protein, lipid and DNA) compared to complexes of fac-[Re(CO) 3 (phen)(py)] + and fac-[Re(CO) 3 (dpq)(py)] + . As consequence, fac-[Re(CO) 3 (dppz)(py)] + exhibited the highest cytotoxicity (IC 50  = 8.5 μM for HeLa cells) for fac-[Re(CO) 3 (dppz)(py)] + among the studied compounds (IC 50  > 15 μM). This highest cytotoxicity of fac-[Re(CO) 3 (dppz)(py)] + are probably related to its lipophilicity, higher permeation of the lipid bilayers of cells, and a more potent interaction of the dppz ligand with biomolecules (protein and DNA). Our findings open novel avenues for rational drug design and highlight the importance of considering the chemical structures of rhenium complexes that strongly interact with biomolecules (proteins, lipids, and DNA).
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Anti-cancer drugs; Biomolecules; Cytotoxicity; Drug design; Organometallic complexes; Rhenium complexes
المشرفين على المادة: 7440-15-5 (Rhenium)
0 (Coordination Complexes)
0 (Antineoplastic Agents)
9007-49-2 (DNA)
0 (Phenanthrolines)
0 (Quinoxalines)
0 (Phenazines)
0 (dipyrido(3,2-a-2',3'-c)phenazine)
W4X6ZO7939 (1,10-phenanthroline)
تواريخ الأحداث: Date Created: 20240517 Date Completed: 20240607 Latest Revision: 20240607
رمز التحديث: 20240608
DOI: 10.1016/j.jinorgbio.2024.112600
PMID: 38759261
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3344
DOI:10.1016/j.jinorgbio.2024.112600