دورية أكاديمية
The effect of hormone therapy on physiological uptake of the endometrium on [ 18 F]F-FDG PET in postmenopausal women.
| العنوان: | The effect of hormone therapy on physiological uptake of the endometrium on [ 18 F]F-FDG PET in postmenopausal women. |
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| المؤلفون: | Nakamoto R; Preemptive Medicine and Lifestyle Related Disease Research Center, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto, 606-8507, Japan. inabook@kuhp.kyoto-u.ac.jp., Yakami M; Preemptive Medicine and Lifestyle Related Disease Research Center, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto, 606-8507, Japan., Nobashi TW; Preemptive Medicine and Lifestyle Related Disease Research Center, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto, 606-8507, Japan., Isoda H; Preemptive Medicine and Lifestyle Related Disease Research Center, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto, 606-8507, Japan., Nakamoto Y; Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. |
| المصدر: | Annals of nuclear medicine [Ann Nucl Med] 2024 Sep; Vol. 38 (9), pp. 726-733. Date of Electronic Publication: 2024 May 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Japan Country of Publication: Japan NLM ID: 8913398 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1864-6433 (Electronic) Linking ISSN: 09147187 NLM ISO Abbreviation: Ann Nucl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tokyo, Japan : Springer Japan Original Publication: Tokyo, Japan : Japanese Society of Nuclear Medicine, [1987- |
| مواضيع طبية MeSH: | Fluorodeoxyglucose F18*/metabolism , Postmenopause* , Endometrium*/diagnostic imaging , Endometrium*/drug effects , Endometrium*/metabolism , Hormone Replacement Therapy* , Positron Emission Tomography Computed Tomography*, Humans ; Female ; Middle Aged ; Aged ; Biological Transport/drug effects ; Retrospective Studies |
| مستخلص: | Objective: The effects of hormonal therapy, estrogen-based hormone replacement therapy (HRT), and anti-tumor hormone therapy, such as tamoxifen, on the physiological uptake of the endometrium on 2-deoxy-2[ 18 F]fluoro-D-glucose ([ 18 F]F-FDG) positron emission tomography (PET) in postmenopausal women have not been determined. We explored the effect of hormone therapy, particularly HRT, on physiological uptake in the endometrium of postmenopausal women. Materials and Methods: Postmenopausal women receiving hormone therapy who underwent cancer screening using PET/computed tomography (CT) between June 2016 and April 2023 were included in the hormone therapy group (n = 21). Postmenopausal women with no history of hormone therapy were included in the control group (n = 49). First, the physiological endometrial uptake at menopausal age and at least 1 year thereafter was compared quantitatively (SUVmax) and qualitatively (4-point scale) in the control group, to assess when the endometrium ceased to show significant physiological [ 18 F]F-FDG uptake after menopause. Endometrial uptake was compared between the hormone therapy and control groups. The association between HRT duration (months) and endometrial uptake (SUVmax) was evaluated. Endometrial thickness, measured using transvaginal ultrasonography, was also compared between the two groups. Results: Endometrial uptake was significantly reduced both qualitatively and quantitatively (P < 0.05) at least 1 year after menopause in control patients, by which time most women (89.8%) no longer had significant endometrial uptake. The hormone therapy group (n = 21) showed higher FDG uptake in the endometrium compared to the control group (median SUVmax: 2.3 vs 1.9, P = 0.0011), as well as a higher visual score (P < 0.0001). HRT duration did not correlate with endometrial uptake (P = 0.097). Endometrial thickness in the hormone therapy group was significantly thicker than in the control group (median: 3.9 mm vs 1.8 mm, P = 0.002). Conclusion: Hormone therapy may affect physiological uptake in the endometrium in postmenopausal women. (© 2024. The Author(s), under exclusive licence to The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine.) |
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| فهرسة مساهمة: | Keywords: Endometrial; Endometrium; Estrogen; Hormone replacement therapy; Menopause; PET; PET/CT; Physiological uptake; Postmenopausal women; [18F]F-FDG |
| المشرفين على المادة: | 0Z5B2CJX4D (Fluorodeoxyglucose F18) |
| تواريخ الأحداث: | Date Created: 20240518 Date Completed: 20240821 Latest Revision: 20240821 |
| رمز التحديث: | 20240821 |
| DOI: | 10.1007/s12149-024-01941-5 |
| PMID: | 38761311 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1864-6433 |
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| DOI: | 10.1007/s12149-024-01941-5 |