دورية أكاديمية
Gastrodin ameliorates synaptic impairment, mitochondrial dysfunction and oxidative stress in N2a/APP cells.
| العنوان: | Gastrodin ameliorates synaptic impairment, mitochondrial dysfunction and oxidative stress in N2a/APP cells. |
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| المؤلفون: | Tang Z; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education and Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, China; Basic Medical College, Guizhou Medical University, Guiyang, China., Peng Y; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education and Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, China; Basic Medical College, Guizhou Medical University, Guiyang, China., Jiang Y; Department of Pathology, Affiliated Hospital of Traditional Chinese Medicine of Guangzhou Medical University, Guangzhou, China., Wang L; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education and Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, China; Basic Medical College, Guizhou Medical University, Guiyang, China., Guo M; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education and Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, China; Basic Medical College, Guizhou Medical University, Guiyang, China., Chen Z; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education and Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, China; Basic Medical College, Guizhou Medical University, Guiyang, China., Luo C; Basic Medical College, Guizhou Medical University, Guiyang, China., Zhang T; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education and Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, China; Basic Medical College, Guizhou Medical University, Guiyang, China., Xiao Y; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education and Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, China; Basic Medical College, Guizhou Medical University, Guiyang, China., Ni R; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland; Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland. Electronic address: ruiqing.ni@uzh.ch., Qi X; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education and Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, China; Basic Medical College, Guizhou Medical University, Guiyang, China. Electronic address: xlq@gmc.edu.cn. |
| المصدر: | Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jul 30; Vol. 719, pp. 150127. Date of Electronic Publication: 2024 May 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002- >: San Diego, CA : Elsevier Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Glucosides*/pharmacology , Benzyl Alcohols*/pharmacology , Oxidative Stress*/drug effects , Mitochondria*/drug effects , Mitochondria*/metabolism , Neuroprotective Agents*/pharmacology , Reactive Oxygen Species*/metabolism , Synapses*/drug effects , Synapses*/metabolism, Animals ; Mice ; Cell Line, Tumor ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Amyloid beta-Protein Precursor/genetics ; Humans ; Alzheimer Disease/metabolism ; Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; tau Proteins/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Peptide Fragments |
| مستخلص: | Alzheimer's disease is characterized by abnormal β-amyloid and tau accumulation, mitochondrial dysfunction, oxidative stress, and synaptic dysfunction. Here, we aimed to assess the mechanisms and signalling pathways in the neuroprotective effect of gastrodin, a phenolic glycoside, on murine neuroblastoma N2a cells expressing human Swedish mutant APP (N2a/APP). We found that gastrodin increased the levels of presynaptic-SNAP, synaptophysin, and postsynaptic-PSD95 and reduced phospho-tau Ser396, APP and Aβ Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Amyloid precursor protein; ERK1/2; GSK-3β; Gastrodin; JNK; Mitochondrial; Oxidative stress; Tau |
| المشرفين على المادة: | 0 (Glucosides) 5YS9U2W3RQ (gastrodin) 0 (Benzyl Alcohols) 0 (Neuroprotective Agents) 0 (Reactive Oxygen Species) 0 (Amyloid beta-Peptides) 0 (Amyloid beta-Protein Precursor) 0 (tau Proteins) 0 (amyloid beta-protein (1-42)) 0 (Peptide Fragments) |
| تواريخ الأحداث: | Date Created: 20240518 Date Completed: 20240603 Latest Revision: 20240612 |
| رمز التحديث: | 20240612 |
| DOI: | 10.1016/j.bbrc.2024.150127 |
| PMID: | 38761634 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2104 |
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| DOI: | 10.1016/j.bbrc.2024.150127 |