دورية أكاديمية
Extreme γ' fibrinogen levels in COVID-19 patients.
| العنوان: | Extreme γ' fibrinogen levels in COVID-19 patients. |
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| المؤلفون: | Hudkins M; Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA., Hamilton H; Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA., Underwood SJ; Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA., Kazmierczak DE; Department of Pathology, Oregon Health & Science University, Portland, OR 97239, USA., Dewey EN; Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA., Kazmierczak SC; Department of Pathology, Oregon Health & Science University, Portland, OR 97239, USA., Messer WB; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA., Khan A; Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Schreiber MA; Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA., Farrell DH; Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: farrelld@ohsu.edu. |
| المصدر: | Blood cells, molecules & diseases [Blood Cells Mol Dis] 2024 Jul; Vol. 107, pp. 102856. Date of Electronic Publication: 2024 Apr 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 9509932 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0961 (Electronic) Linking ISSN: 10799796 NLM ISO Abbreviation: Blood Cells Mol Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1996-> : Orlando, FL : Academic Press Original Publication: La Jolla, Calif. : Blood Cells Foundation, 1995- |
| مواضيع طبية MeSH: | COVID-19*/blood , COVID-19*/complications , SARS-CoV-2* , Fibrinogen*/analysis , Fibrinogen*/metabolism , Biomarkers*/blood, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Aged ; Adult ; Disease Progression |
| مستخلص: | COVID-19 disease progression can be accompanied by a "cytokine storm" that leads to secondary sequelae such as acute respiratory distress syndrome. Several inflammatory cytokines have been associated with COVID-19 disease progression, but have high daily intra-individual variability. In contrast, we have shown that the inflammatory biomarker γ' fibrinogen (GPF) has a 6-fold lower coefficient of variability compared to other inflammatory markers such as hs-CRP. The aims of the study were to measure GPF in serial blood samples from COVID-19 patients at a tertiary care medical center in order to investigate its association with clinical measures of disease progression. COVID-19 patients were retrospectively enrolled between 3/16/2020 and 8/1/2020. GPF was measured using a commercial ELISA. We found that COVID-19 patients can develop extraordinarily high levels of GPF. Our results showed that ten out of the eighteen patients with COVID-19 had the highest levels of GPF ever recorded. The previous highest GPF level of 80.3 mg/dL was found in a study of 10,601 participants in the ARIC study. GPF levels were significantly associated with the need for ECMO and mortality. These findings have potential implications regarding prophylactic anticoagulation of COVID-19 patients. Competing Interests: Declaration of competing interest OHSU and David H. Farrell have a significant interest in Gamma Diagnostics, a company that may have a commercial interest in the results of this research and technology. This potential individual and institutional conflict of interest has been reviewed and managed by OHSU. None of the other authors declare any competing interests. Gamma Diagnostics played no role in conducting this study or writing this manuscript. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biomarkers; COVID-19; Fibrinogen |
| المشرفين على المادة: | 9001-32-5 (Fibrinogen) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240519 Date Completed: 20240604 Latest Revision: 20240612 |
| رمز التحديث: | 20240612 |
| DOI: | 10.1016/j.bcmd.2024.102856 |
| PMID: | 38762921 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-0961 |
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| DOI: | 10.1016/j.bcmd.2024.102856 |