دورية أكاديمية
Age-dependent distribution of IgA and IgG antibody-secreting cells in the pharyngeal tonsil of the Bactrian camel.
| العنوان: | Age-dependent distribution of IgA and IgG antibody-secreting cells in the pharyngeal tonsil of the Bactrian camel. |
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| المؤلفون: | Fang YD; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China., Xie F; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China., Zhang WD; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China., Zeng WW; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China., Lu J; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China., Cheng YJ; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China., Wang WH; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China. Electronic address: wwh777@126.com. |
| المصدر: | Veterinary journal (London, England : 1997) [Vet J] 2024 Jun; Vol. 305, pp. 106131. Date of Electronic Publication: 2024 May 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Balliere Tindall Country of Publication: England NLM ID: 9706281 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2971 (Electronic) Linking ISSN: 10900233 NLM ISO Abbreviation: Vet J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Balliere Tindall Original Publication: London : Ballière Tindall, c1997- |
| مواضيع طبية MeSH: | Camelus*/immunology , Immunoglobulin G* , Immunoglobulin A*/analysis , Antibody-Producing Cells*/immunology, Animals ; Aging ; Age Factors ; Male ; Immunity, Mucosal ; Adenoids/immunology ; Female ; Palatine Tonsil/immunology ; Palatine Tonsil/cytology |
| مستخلص: | The pharyngeal tonsil, located in the nasopharynx, can effectively defend against pathogens invading the body from the upper respiratory tract and play a crucial role in mucosal immunity of the respiratory tract. Immunoglobulin A (IgA) and Immunoglobulin G (IgG) serve as key effector molecules in mucosal immunity, exhibiting multiple immune functions. This study aimed to investigate the distribution patterns and age-related alterations of IgA and IgG antibody-secreting cells (ASCs) in the pharyngeal tonsils of Bactrian camels. Twelve Alashan Bactrian camels were categorized into four age groups: young (1-2 years, n=3), pubertal (3-5 years, n=3), middle-aged (6-16 years, n=3) and old (17-20 years, n=3). The distribution patterns of IgA and IgG ASCs in the pharyngeal tonsils of Bactrian camels of different ages were meticulously observed, analyzed and compared using immunohistochemical and statistical methods. The results revealed that IgA ASCs in the pharyngeal tonsils of all age groups were primarily clustered or diffusely distributed in the reticular epithelium and its subepithelial regions (region A) and around the glands (region C), scattered in the subepithelial regions of non-reticular epithelium (region B), and sporadically distributed in the interfollicular regions (region D). Interestingly, the distribution pattern of IgG ASCs in the pharyngeal tonsils closely mirrored that of IgA ASCs. The distribution densities of IgA and IgG ASCs in these four regions were significantly decreased in turn (P<0.05). However, IgA ASCs exhibited significantly higher densities than IgG ASCs in the same region (P<0.05). Age-related alterations indicated that the distribution densities of IgA and IgG ASCs in each region of the pharyngeal tonsils exhibited a trend of initially increasing and subsequently decreasing from young to old camels, reaching a peak in the pubertal group. As camels age, there was a significant decrease in the densities of IgA and IgG ASCs in all regions of the pharyngeal tonsils (P<0.05). The results demonstrate that the reticular epithelium and its subepithelial regions in the pharyngeal tonsils of Bactrian camels are the primary regions where IgA and IgG ASCs colonize and exert their immune functions. These regions play a pivotal role in inducing immune responses and defending against pathogen invasions in the pharyngeal tonsils. IgA ASCs may be the principal effector cells of the mucosal immune response in the pharyngeal tonsils of Bactrian camels. Aging significantly reduces the densities of IgA and IgG ASCs, while leaving their distribution patterns unaffected. These findings will provide valuable insights for further investigations into the immunomorphology, immunosenescence, and response mechanisms of the pharyngeal tonsils in Bactrian camels. Competing Interests: Conflict of Interest None of the authors has any other financial or personal relationships that could inappropriately influence or bias the content of the paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aging; Bactrian camels; Distribution; IgA antibody secreting cells; IgG antibody secreting cells; Pharyngeal tonsil |
| المشرفين على المادة: | 0 (Immunoglobulin G) 0 (Immunoglobulin A) |
| تواريخ الأحداث: | Date Created: 20240519 Date Completed: 20240619 Latest Revision: 20240619 |
| رمز التحديث: | 20240620 |
| DOI: | 10.1016/j.tvjl.2024.106131 |
| PMID: | 38763403 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-2971 |
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| DOI: | 10.1016/j.tvjl.2024.106131 |