دورية أكاديمية
أعرض في EDS

Angiopoietin-like 4 is upregulated by amphiregulin and activates cell proliferation and migration through p38 kinase in head and neck squamous cell carcinoma.

التفاصيل البيبلوغرافية
العنوان: Angiopoietin-like 4 is upregulated by amphiregulin and activates cell proliferation and migration through p38 kinase in head and neck squamous cell carcinoma.
المؤلفون: Kumar A; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA., Asiedu E; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA., Hefni E; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA.; Department of Basic and Clinical Oral Sciences, College of Dental Medicine, Umm Al Qura University, Makkah, Saudi Arabia., Armstrong C; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA., Menon D; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA., Ma T; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA., Sands L; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA., Mbadugha E; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA., Sodhi A; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Schneider A; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA.; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Maryland, USA., Montaner S; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA.; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Maryland, USA.
المصدر: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2024 Jul; Vol. 53 (6), pp. 366-375. Date of Electronic Publication: 2024 May 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 8911934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0714 (Electronic) Linking ISSN: 09042512 NLM ISO Abbreviation: J Oral Pathol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Copenhagen : Munksgaard, c1989-
مواضيع طبية MeSH: Amphiregulin*/pharmacology , Amphiregulin*/metabolism , Cell Proliferation*/drug effects , p38 Mitogen-Activated Protein Kinases*/metabolism , Cell Movement*/drug effects , Up-Regulation* , Head and Neck Neoplasms*/metabolism , Head and Neck Neoplasms*/pathology , Squamous Cell Carcinoma of Head and Neck*/pathology , Squamous Cell Carcinoma of Head and Neck*/metabolism , Angiopoietin-Like Protein 4*/metabolism, Humans ; Cell Line, Tumor ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/metabolism ; Signal Transduction ; Keratinocytes/metabolism ; Keratinocytes/drug effects ; ErbB Receptors/metabolism
مستخلص: Background: Angiopoietin-like 4 is a molecular hallmark that correlates with the growth and metastasis of head and neck squamous cell carcinoma, one of the most prevalent cancers worldwide. However, the molecular mechanisms by which angiopoietin-like 4 promotes head and neck squamous cell carcinoma tumorigenesis are unclear.
Methods: Using well-characterized cell lines of head and neck squamous cell carcinoma development, including human normal oral keratinocytes, dysplastic oral keratinocytes, oral leukoplakia-derived oral keratinocytes, and head and neck squamous cell carcinoma cell lines, HN13, HN6, HN4, HN12, and CAL27, we investigated the signaling pathways upstream and downstream of angiopoietin-like 4-induced head and neck squamous cell carcinoma tumorigenesis.
Results: We found that both epidermal growth factor receptor ligands, epithelial growth factor, and amphiregulin led to angiopoietin-like 4 upregulation in normal oral keratinocytes and dysplastic oral keratinocytes and cooperated with the activation of hypoxia-inducible factor-1 in this effect. Interestingly, amphiregulin and angiopoietin-like 4 were increased in dysplastic oral keratinocytes and head and neck squamous cell carcinoma cell lines, and amphiregulin-induced activation of cell proliferation was dependent on angiopoietin-like 4. Although both p38 mitogen-activated protein kinases (p38 MAPK) and protein kinase B (AKT) were activated by angiopoietin-like 4, only pharmacological inhibition of p38 MAPK was sufficient to prevent head and neck squamous cell carcinoma cell proliferation and migration. We further observed that angiopoietin-like 4 promoted the secretion of interleukin 11 (IL-11), interleukin 12 (IL-12), interleukin-1 alpha (IL-1α), vascular endothelial growth factor, platelet-derived growth factor (PDGF), and tumour necrosis factor alpha (TNF-α), cytokines and chemokines previously implicated in head and neck squamous cell carcinoma pathogenesis.
Conclusion: Our results demonstrate that angiopoietin-like 4 is a downstream effector of amphiregulin and promotes head and neck squamous cell carcinoma development both through direct activation of p38 kinase as well as paracrine mechanisms.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: R01 CA119911 United States CA NCI NIH HHS; Saudi Arabian Cultural Mission (SACM); Umm Al Qura University (UQU); NIH R01CA119911 the Dental Biomedical Sciences graduate program of the UMB Dental School
فهرسة مساهمة: Keywords: amphiregulin; angiopoietins; carcinogenesis; epidermal growth factor; squamous cell carcinoma of head and neck
المشرفين على المادة: 0 (Amphiregulin)
EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
0 (Angiopoietin-Like Protein 4)
0 (AREG protein, human)
EC 2.7.10.1 (ErbB Receptors)
تواريخ الأحداث: Date Created: 20240519 Date Completed: 20240705 Latest Revision: 20240710
رمز التحديث: 20240710
DOI: 10.1111/jop.13545
PMID: 38763759
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-0714
DOI:10.1111/jop.13545