دورية أكاديمية
Research progress on genetics in cardioembolic stroke.
| العنوان: | Research progress on genetics in cardioembolic stroke. |
|---|---|
| المؤلفون: | Tang HL; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524002, China., Zheng ST; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524002, China., Li Y; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524002, China.; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Zhanjiang 524002, China., Zhong WT; Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524002, China.; Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Zhanjiang 524002, China. |
| المصدر: | Yi chuan = Hereditas [Yi Chuan] 2024 May 20; Vol. 46 (5), pp. 373-386. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Ke xue chu ban she Country of Publication: China NLM ID: 9436478 Publication Model: Print Cited Medium: Print ISSN: 0253-9772 (Print) Linking ISSN: 02539772 NLM ISO Abbreviation: Yi Chuan Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Ke xue chu ban she, |
| مواضيع طبية MeSH: | Genome-Wide Association Study* , DNA Copy Number Variations* , Genetic Predisposition to Disease* , Embolic Stroke*/genetics , Embolic Stroke*/etiology, Humans ; Risk Factors |
| مستخلص: | Cardioembolic stroke, characterized by severe illness, poor prognosis, and high recurrence rate, is one of the important causes of ischemic stroke. In the field of genetic research, numerous genes associated with cardioembolic stroke have been identified, and their potential in predicting disease risk and evaluating risk factors has been progressively explored. Here, we provide an overview of the latest advancements in genetics for cardioembolic stroke, including genome-wide association studies, copy number variation studies, whole-genome sequencing studies. Furthermore, we also summarize the application of genetic datasets in polygenic risk score and Mendelian randomization. The aim of this overview is to provide insights and references from multiple perspectives for future investigations on the genetic information for cardioembolic stroke. |
| فهرسة مساهمة: | Keywords: Mendelian randomization; cardioembolic stroke; genome-wide association study; polygenic risk score; stroke Local Abstract: [Publisher, Chinese] 心源性卒中是缺血性脑卒中的重要病因之一，表现出病情重、预后差和复发率高的特点。在遗传学研究中已经有相当多与心源性卒中相关的基因被鉴定，这些易感基因在疾病风险预测及危险因素评估的潜力也陆续被发掘。本文从全基因组关联研究、拷贝数变异研究、全基因组测序研究等方面综述了心源性卒中遗传学研究的相关进展，并介绍了其遗传数据集在多基因风险评分、孟德尔随机化的应用，旨在为将来深入研究心源性卒中的遗传发生机制提供借鉴和参考。. |
| تواريخ الأحداث: | Date Created: 20240519 Date Completed: 20240519 Latest Revision: 20240703 |
| رمز التحديث: | 20240703 |
| DOI: | 10.16288/j.yczz.23-282 |
| PMID: | 38763772 |
| قاعدة البيانات: | MEDLINE |
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