دورية أكاديمية
أعرض في EDS

Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting.

التفاصيل البيبلوغرافية
العنوان: Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting.
المؤلفون: Steinhoff JS; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Wagner C; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Dähnhardt HE; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Košić K; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Meng Y; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Taschler U; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Pajed L; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Yang N; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Wulff S; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Kiefer MF; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Petricek KM; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Flores RE; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Li C; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Dittrich S; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Sommerfeld M; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Guillou H; Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP- PURPAN, UMR 1331, UPS, Université de Toulouse, Toulouse, France., Henze A; Martin Luther University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences, Halle, Germany.; Junior Research Group ProAID, Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., Raila J; Department of Physiology and Pathophysiology, Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., Wowro SJ; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany., Schoiswohl G; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria., Lass A; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria. achim.lass@uni-graz.at.; BioTechMed-Graz, Graz, Austria. achim.lass@uni-graz.at., Schupp M; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany. michael.schupp@charite.de.
المصدر: EMBO reports [EMBO Rep] 2024 Jul; Vol. 25 (7), pp. 2878-2895. Date of Electronic Publication: 2024 May 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Blackwell Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : London, UK : Wiley Blackwell
Original Publication: Oxford, UK : Published for EMBO by Oxford University Press, 2000-
مواضيع طبية MeSH: Retinol-Binding Proteins, Plasma*/metabolism , Retinol-Binding Proteins, Plasma*/genetics , Vitamin A*/metabolism , Vitamin A*/blood , Fasting*/metabolism , Adipocytes*/metabolism , Sterol Esterase*/metabolism , Sterol Esterase*/genetics, Animals ; Mice ; Liver/metabolism ; Adipose Tissue/metabolism ; Mice, Knockout ; Mice, Inbred C57BL
مستخلص: Vitamin A (retinol) is distributed via the blood bound to its specific carrier protein, retinol-binding protein 4 (RBP4). Retinol-loaded RBP4 is secreted into the circulation exclusively from hepatocytes, thereby mobilizing hepatic retinoid stores that represent the major vitamin A reserves in the body. The relevance of extrahepatic retinoid stores for circulating retinol and RBP4 levels that are usually kept within narrow physiological limits is unknown. Here, we show that fasting affects retinoid mobilization in a tissue-specific manner, and that hormone-sensitive lipase (HSL) in adipose tissue is required to maintain serum concentrations of retinol and RBP4 during fasting in mice. We found that extracellular retinol-free apo-RBP4 induces retinol release by adipocytes in an HSL-dependent manner. Consistently, global or adipocyte-specific HSL deficiency leads to an accumulation of retinoids in adipose tissue and a drop of serum retinol and RBP4 during fasting, which affects retinoid-responsive gene expression in eye and kidney and lowers renal retinoid content. These findings establish a novel crosstalk between liver and adipose tissue retinoid stores for the maintenance of systemic vitamin A homeostasis during fasting.
(© 2024. The Author(s).)
References: J Biol Chem. 1997 May 30;272(22):14159-65. (PMID: 9162045)
J Biol Chem. 2019 Jun 7;294(23):9118-9133. (PMID: 31023823)
Cell Metab. 2007 Mar;5(3):164-6. (PMID: 17339024)
J Biol Chem. 2015 Mar 13;290(11):7259-68. (PMID: 25627686)
Nature. 1992 Jan 23;355(6358):359-61. (PMID: 1309942)
J Membr Biol. 2012 Nov;245(11):731-45. (PMID: 22815070)
FEBS J. 2019 Nov;286(21):4232-4244. (PMID: 31199585)
Cell Rep. 2022 Jun 7;39(10):110910. (PMID: 35675775)
Cell. 1992 Jan 24;68(2):397-406. (PMID: 1310260)
J Biol Chem. 2013 Jan 11;288(2):1250-65. (PMID: 23105095)
Nat Chem Biol. 2013 Dec;9(12):785-7. (PMID: 24096302)
EMBO J. 1999 Sep 1;18(17):4633-44. (PMID: 10469643)
J Biol Chem. 1995 Jan 13;270(2):866-70. (PMID: 7822324)
J Lipid Res. 2022 Oct;63(10):100268. (PMID: 36030930)
Cell Metab. 2008 Mar;7(3):258-68. (PMID: 18316031)
Am J Physiol. 1994 Feb;266(2 Pt 1):E179-85. (PMID: 8141275)
Exp Cell Res. 1991 Nov;197(1):119-24. (PMID: 1915658)
Nature. 1987 Dec 3-9;330(6147):444-50. (PMID: 2825025)
J Biol Chem. 2004 Mar 12;279(11):10422-32. (PMID: 14684738)
Biochemistry. 1999 Mar 2;38(9):2647-53. (PMID: 10052934)
Int J Biochem Cell Biol. 2009 Nov;41(11):2189-203. (PMID: 19389484)
Int J Biol Macromol. 2007 Apr 10;40(5):484-90. (PMID: 17184834)
Nutrients. 2011 Jan;3(1):63-103. (PMID: 21350678)
Data Brief. 2018 Mar 29;18:1073-1081. (PMID: 29900277)
Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1182-95. (PMID: 12954598)
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. (PMID: 26508640)
J Biol Chem. 2005 Dec 2;280(48):40226-34. (PMID: 16174770)
Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):787-92. (PMID: 10639158)
Cell Metab. 2007 Jun;5(6):415-25. (PMID: 17550777)
Nat Commun. 2023 Feb 15;14(1):851. (PMID: 36792627)
J Lipid Res. 2022 Mar;63(3):100173. (PMID: 35101424)
ACS Chem Biol. 2011 Oct 21;6(10):1041-51. (PMID: 21774515)
Nat Rev Mol Cell Biol. 2011 Mar;12(3):141-51. (PMID: 21346730)
EMBO J. 2000 Mar 1;19(5):989-96. (PMID: 10698940)
J Nutr. 1988 Feb;118(2):199-205. (PMID: 3339478)
Science. 1995 May 19;268(5213):1039-41. (PMID: 7754382)
Nutrients. 2022 Mar 15;14(6):. (PMID: 35334893)
Am J Physiol Endocrinol Metab. 2004 May;286(5):E844-51. (PMID: 14736708)
Cell. 1974 Oct;3(2):127-33. (PMID: 4426090)
Mol Cell Biol. 2014 Mar;34(6):1170-86. (PMID: 24421389)
J Hepatol. 2015 Aug;63(2):437-45. (PMID: 25733154)
PLoS Genet. 2015 Jun 01;11(6):e1005213. (PMID: 26030625)
Methods Mol Biol. 2010;652:341-61. (PMID: 20552439)
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Nov;1865(11):158580. (PMID: 31794861)
Science. 2000 Aug 4;289(5480):739-45. (PMID: 10926528)
Commun Biol. 2023 May 17;6(1):533. (PMID: 37198396)
Mol Cell Biol. 2013 Oct;33(20):4068-82. (PMID: 23959802)
Cell Metab. 2007 Sep;6(3):208-16. (PMID: 17767907)
Genes Cells. 2012 Sep;17(9):758-67. (PMID: 22845550)
Mol Cell Biol. 2018 May 29;38(12):. (PMID: 29581184)
Recent Prog Horm Res. 1998;53:139-59; discussion 160-1. (PMID: 9769707)
J Clin Invest. 1999 Jun;103(11):1489-98. (PMID: 10359558)
Nature. 2005 Jul 21;436(7049):356-62. (PMID: 16034410)
J Biol Chem. 2020 Dec 11;295(50):17158-17168. (PMID: 33023907)
Exp Cell Res. 1996 Jan 10;222(1):77-83. (PMID: 8549676)
Endocrinology. 2010 Nov;151(11):5174-84. (PMID: 20844005)
J Biol Chem. 2006 Dec 29;281(52):40236-41. (PMID: 17074755)
J Proteome Res. 2006 Jul;5(7):1701-10. (PMID: 16823978)
Diabetes. 2017 Jan;66(1):58-63. (PMID: 27797907)
FASEB J. 1996 Jul;10(9):961-8. (PMID: 8801178)
Nutrients. 2016 Dec 27;9(1):. (PMID: 28035980)
J Biol Chem. 2000 Feb 18;275(7):5011-5. (PMID: 10671541)
Protein Expr Purif. 2010 May;71(1):28-32. (PMID: 20093188)
Biochim Biophys Acta. 2012 Jan;1821(1):113-23. (PMID: 21586336)
Trends Pharmacol Sci. 2020 Jun;41(6):418-427. (PMID: 32345479)
PNAS Nexus. 2023 May 19;2(6):pgad167. (PMID: 37275262)
Cell Metab. 2007 Jun;5(6):426-37. (PMID: 17550778)
Invest Ophthalmol Vis Sci. 2013 Jan 07;54(1):85-95. (PMID: 23211825)
J Biol Chem. 2002 Feb 15;277(7):4806-15. (PMID: 11717312)
BMC Genomics. 2013 Nov 05;14:758. (PMID: 24191950)
Arch Biochem Biophys. 1998 Sep 1;357(1):126-30. (PMID: 9721191)
Mol Cell Endocrinol. 2018 Aug 15;471:75-88. (PMID: 28774777)
J Biol Chem. 2002 Aug 16;277(33):30191-7. (PMID: 12048218)
Cells. 2022 Mar 17;11(6):. (PMID: 35326472)
Ann N Y Acad Sci. 1980;348:378-90. (PMID: 6994566)
Endocrinology. 2012 Mar;153(3):1162-73. (PMID: 22253419)
Endocrinology. 1999 Jul;140(7):3140-6. (PMID: 10385407)
Biochim Biophys Acta. 2015 Jul;1851(7):937-45. (PMID: 25732851)
J Clin Invest. 1968 Sep;47(9):2025-44. (PMID: 5675424)
Commun Biol. 2021 Mar 10;4(1):323. (PMID: 33692445)
Nat Commun. 2017 Aug 30;8(1):384. (PMID: 28855500)
J Med Chem. 2019 Jun 13;62(11):5470-5500. (PMID: 31079449)
Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 2):S52-62. (PMID: 8811064)
FASEB J. 2009 Jul;23(7):2307-16. (PMID: 19246492)
Endocrinology. 2015 Nov;156(11):4008-19. (PMID: 26181104)
Nat Methods. 2012 Jul;9(7):671-5. (PMID: 22930834)
Diabetes Metab. 2020 Apr;46(2):129-136. (PMID: 31163275)
Cell Metab. 2019 Feb 5;29(2):246-253. (PMID: 30726758)
Mol Cell Endocrinol. 2021 Jul 1;531:111312. (PMID: 33957191)
معلومات مُعتمدة: 2546/8-1 Deutsche Forschungsgemeinschaft (DFG); WO 2624/1-1 Deutsche Forschungsgemeinschaft (DFG); 10.55776/P34899 Austrian Science Fund (FWF); SCHU 2546/5-1 Deutsche Forschungsgemeinschaft (DFG); SCHU 2546/7-1 Deutsche Forschungsgemeinschaft (DFG); 10.55776/I3535 Austrian Science Fund (FWF); 01EA1706 Bundesministerium für Bildung und Forschung (BMBF); DOC 50 Austria FWF_ Austrian Science Fund FWF
فهرسة مساهمة: Keywords: Fasting; HSL; RBP4; Retinol; Vitamin A
المشرفين على المادة: 0 (Retinol-Binding Proteins, Plasma)
11103-57-4 (Vitamin A)
0 (Rbp4 protein, mouse)
EC 3.1.1.13 (Sterol Esterase)
تواريخ الأحداث: Date Created: 20240520 Date Completed: 20240711 Latest Revision: 20240724
رمز التحديث: 20240725
مُعرف محوري في PubMed: PMC11239848
DOI: 10.1038/s44319-024-00158-x
PMID: 38769419
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-3178
DOI:10.1038/s44319-024-00158-x