دورية أكاديمية
Five new flavonoids and their pharmacological activities from Iris tenuifolia Pall.
| العنوان: | Five new flavonoids and their pharmacological activities from Iris tenuifolia Pall. |
|---|---|
| المؤلفون: | Yan H; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Da Dao, Nanjing 211198, People's Republic of China., Lyu H; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 639 Long Mian Da Dao, Nanjing 211198, People's Republic of China; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai, China., Otgon O; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Da Dao, Nanjing 211198, People's Republic of China; Department of Chemistry, School of Biomedicine, Mongolian National University of Medical Sciences, S. Zorig Street 3, Ulaanbaatar 14210, Mongolia., Lu J; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Da Dao, Nanjing 211198, People's Republic of China., Peng D; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Da Dao, Nanjing 211198, People's Republic of China., Zhu Y; Department of Anesthesiology, The First People´s Hospital of Yunnan Province, 157 Jinbi Road, Kunming, 650034, People's Republic of China. Electronic address: 328376727@qq.com., Jiang J; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Da Dao, Nanjing 211198, People's Republic of China. Electronic address: njjjq@aliyun.com. |
| المصدر: | Fitoterapia [Fitoterapia] 2024 Jul; Vol. 176, pp. 106022. Date of Electronic Publication: 2024 May 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : [Amsterdam] : Elsevier Original Publication: Milano : Inverni & Della Beffa S.p.A. |
| مواضيع طبية MeSH: | Flavonoids*/pharmacology , Flavonoids*/isolation & purification , Flavonoids*/chemistry , Iris Plant*/chemistry , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/isolation & purification , Glycoside Hydrolase Inhibitors*/chemistry , Antioxidants*/pharmacology , Antioxidants*/isolation & purification, Molecular Structure ; Isoflavones/pharmacology ; Isoflavones/isolation & purification ; Isoflavones/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/isolation & purification |
| مستخلص: | Five new components including two new isoflavones, 5, 7, 2', 3'-tetrahydroxy-6-methoxyisoflavone (1), 5, 7, 2', 3'-tetrahydroxy-8-methoxyisoflavone (2), one flavonol 3, 5, 3', 4'-tetrahydroxy-7, 2'-dimethoxyflavonol (3), one flavanone (2S)-5, 7, 3'-trihydroxy-2'-methoxyflavanone (4), and one flavanonol (2R, 3R)-3, 5, 3', 4'-tetrahydroxy-7, 2'-dimethoxyflavanonol (5), along with nine known flavonoids (6-14) were isolated from under ground parts of Iris tenuifolia Pall. Their structures were elucidated by NMR and HRESIMS data and by comparison of CD spectra with compounds having similar structure. The separated compounds were evaluated for in vitro antioxidant activities by DPPH and ABTS. The α-glucosidase inhibitory activity of the compounds were evaluated with the pNPG method, the results indicated flavonoids were potential inhibitors of α-glucosidase. Moreover, in vitro anti-oxidative assay using flow cytometry indicated that compounds 1-5 showed strong oxidation resistance ability on C8D1A cells without affecting the cell viability. Competing Interests: Declaration of competing interest The authors declare no competing financial interests. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anti-α-glucosidase activity; Antioxidant activity; Flavonoid; Iris tenuifolia Pall.; ROS |
| المشرفين على المادة: | 0 (Flavonoids) 0 (Glycoside Hydrolase Inhibitors) 0 (Antioxidants) 0 (Isoflavones) 0 (Phytochemicals) |
| تواريخ الأحداث: | Date Created: 20240521 Date Completed: 20240616 Latest Revision: 20240616 |
| رمز التحديث: | 20240617 |
| DOI: | 10.1016/j.fitote.2024.106022 |
| PMID: | 38772509 |
| قاعدة البيانات: | MEDLINE |
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