دورية أكاديمية
Predictors of histologic remission in patients with biologic-naïve, moderate-to-severe ulcerative colitis treated with first-line biologic agents and small-molecule drugs: a single-center, retrospective cohort study.
| العنوان: | Predictors of histologic remission in patients with biologic-naïve, moderate-to-severe ulcerative colitis treated with first-line biologic agents and small-molecule drugs: a single-center, retrospective cohort study. |
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| المؤلفون: | Jo K; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea., Kim KW; Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea., Lee HJ; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea., Im JP; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea., Kim JS; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea., Koh SJ; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. |
| المصدر: | Intestinal research [Intest Res] 2024 May 22. Date of Electronic Publication: 2024 May 22. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taehan Chang Yŏn'gu Hakhoe Country of Publication: Korea (South) NLM ID: 101572802 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1598-9100 (Print) Linking ISSN: 15989100 NLM ISO Abbreviation: Intest Res |
| أسماء مطبوعة: | Original Publication: Sŏul : Taehan Chang Yŏn'gu Hakhoe |
| مستخلص: | Background/aims: The prevalence and incidence of ulcerative colitis (UC) in Korea is increasing. Each patient has a different disease course and treatment response. Recently, with the development of biologic agents, histological remission has become a treatment goal. In this study, we aimed to identify the predictors of histological remission after first-line biologic agent treatment in patients with biologic agent-naïve UC. Methods: We retrospectively analyzed the medical records of 92 patients who had been diagnosed with UC and treated with first-line biologic agent treatment at our center, between 2015 and 2022. The clinical characteristics, laboratory test results, and endoscopic and biopsy findings were analyzed. Histological remission was defined as the absence of cryptitis, crypt abscesses, and inflammatory cells on histology. Univariate and multivariate logistic regression analyses were performed to identify the predictors of histological remission after first-line treatment. Results: Of the total 92 patients, 25 (27.2%) achieved histological remission. Each cohort had a varied body mass index (BMI) distribution, with a statistically significant overweight ratio, as defined by the Asian-Pacific BMI category of 23-25 kg/m2, of 48.0% in the histological remission cohort (P= 0.026). A causal correlation between the overweight category and histological remission was confirmed (odds ratio, 3.883; 95% confidence interval, 1.141-13.212; P= 0.030). Conclusions: We confirmed that the overweight category was a predictor of histological remission after first-line treatment with a biological agent. However, as BMI does not account for skeletal muscle mass, future studies are required to confirm the correlation between skeletal muscle mass and histological remission. |
| فهرسة مساهمة: | Keywords: Body mass index; Histologic remission; Ulcerative colitis |
| تواريخ الأحداث: | Date Created: 20240521 Latest Revision: 20240521 |
| رمز التحديث: | 20240522 |
| DOI: | 10.5217/ir.2024.00044 |
| PMID: | 38772863 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1598-9100 |
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| DOI: | 10.5217/ir.2024.00044 |