دورية أكاديمية
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Gamma radiation assisted green synthesis of hesperidin-reduced graphene oxide nanocomposite targeted JNK/SMAD4/MMP2 signaling pathway.

التفاصيل البيبلوغرافية
العنوان: Gamma radiation assisted green synthesis of hesperidin-reduced graphene oxide nanocomposite targeted JNK/SMAD4/MMP2 signaling pathway.
المؤلفون: Kodous AS; Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt., Taha EO; Petroleum Applications Department, Egyptian Petroleum Research Institute (EPRI), Cairo, Egypt., El-Maghraby DF; Health Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt., Hassana AA; Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt. asmaabubakr98@yahoo.com., Atta MM; Radiation Physics Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt. mohatta2014@gmail.com.
المصدر: Scientific reports [Sci Rep] 2024 May 21; Vol. 14 (1), pp. 11535. Date of Electronic Publication: 2024 May 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Graphite*/chemistry , Graphite*/pharmacology , Nanocomposites*/chemistry , Hesperidin*/pharmacology , Hesperidin*/chemistry , Smad4 Protein*/metabolism , Matrix Metalloproteinase 2*/metabolism , Matrix Metalloproteinase 2*/genetics , Gamma Rays*, Humans ; Green Chemistry Technology/methods ; Signal Transduction/drug effects ; Caco-2 Cells ; Hep G2 Cells ; Cell Line, Tumor ; MAP Kinase Kinase 4/metabolism
مستخلص: In this study, a novel method for the fabrication of hesperidin/reduced graphene oxide nanocomposite (RGOH) with the assistance of gamma rays is reported. The different RGOHs were obtained by varying hesperidin concentrations (25, 50, 100, and 200 wt.%) in graphene oxide (GO) solution. Hesperidin concentrations (25, 50, 100, and 200 wt.%) in graphene oxide (GO) were varied to produce the various RGOHs. Upon irradiation with 80 kGy from γ-Ray, the successful reduction of GO occurred in the presence of hesperidin. The reduction process was confirmed by different characterization techniques such as FTIR, XRD, HRTEM, and Raman Spectroscopy. A cytotoxicity study using the MTT method was performed to evaluate the cytotoxic-anticancer effects of arbitrary RGOH on Wi38, CaCo2, and HepG2 cell lines. The assessment of RGOH's anti-inflammatory activity, including the monitoring of IL-1B and IL-6 activities as well as NF-kB gene expression was done. In addition, the anti-invasive and antimetastatic properties of RGOH, ICAM, and VCAM were assessed. Additionally, the expression of the MMP2-9 gene was quantified. The assessment of apoptotic activity was conducted by the detection of gene expressions related to BCl2 and P53. The documentation of the JNK/SMAD4/MMP2 signaling pathway was ultimately accomplished. The findings of our study indicate that RGOH therapy has significant inhibitory effects on the JNK/SMAD4/MMP2 pathway. This suggests that it could be a potential therapeutic option for cancer.
(© 2024. The Author(s).)
References: Nat Commun. 2018 Feb 8;9(1):559. (PMID: 29422647)
Cancers (Basel). 2021 May 03;13(9):. (PMID: 34063627)
Asian Pac J Cancer Prev. ;18(4):955-961. (PMID: 28545193)
Biol Trace Elem Res. 2023 Jan;201(1):306-323. (PMID: 35237941)
Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
Cancer Res. 2014 Apr 15;74(8):2182-92. (PMID: 24737129)
Aging (Albany NY). 2020 Sep 14;12(17):17625-17633. (PMID: 32924971)
Oncol Lett. 2016 May;11(5):3465-3470. (PMID: 27123137)
Life Sci. 2015 Mar 1;124:64-74. (PMID: 25625242)
Drug Deliv. 2021 Dec;28(1):1982-1994. (PMID: 34569406)
Int J Mol Sci. 2021 Jan 06;22(2):. (PMID: 33419226)
PLoS One. 2015 Dec 14;10(12):e0144842. (PMID: 26658644)
ACS Appl Mater Interfaces. 2013 Dec 26;5(24):12928-34. (PMID: 24182328)
Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17117-22. (PMID: 21949408)
Genes Dev. 2018 Oct 1;32(19-20):1267-1284. (PMID: 30275043)
Part Fibre Toxicol. 2013 Jul 12;10:27. (PMID: 23849434)
Cell Commun Signal. 2023 Sep 28;21(1):266. (PMID: 37770930)
Oncol Res. 2023 Feb 9;30(6):269-276. (PMID: 37303494)
Mol Cell Biochem. 2016 Jun;417(1-2):35-47. (PMID: 27160935)
Asian Pac J Cancer Prev. 2012;13(4):1297-303. (PMID: 22799322)
Cell Mol Life Sci. 2020 Nov;77(22):4449-4458. (PMID: 32322927)
Adv Drug Deliv Rev. 2016 Oct 1;105(Pt B):145-162. (PMID: 27569910)
Clin Exp Immunol. 2006 Jun;144(3):494-502. (PMID: 16734619)
ACS Nano. 2010 Aug 24;4(8):4806-14. (PMID: 20731455)
Rep Biochem Mol Biol. 2023 Jan;11(4):532-546. (PMID: 37131903)
ACS Omega. 2021 Jun 04;6(23):15147-15155. (PMID: 34151094)
Biomaterials. 2014 Feb;35(5):1597-607. (PMID: 24290441)
Cells. 2020 May 06;9(5):. (PMID: 32384712)
Exp Biol Med (Maywood). 2020 Mar;245(5):486-497. (PMID: 32050794)
Nutr Cancer. 2016;68(1):29-39. (PMID: 26381129)
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):378-394. (PMID: 30691314)
Discov Med. 2010 Feb;9(45):145-52. (PMID: 20193641)
J Cell Sci. 2003 Oct 15;116(Pt 20):4077-85. (PMID: 12972501)
Int J Mol Sci. 2022 Aug 18;23(16):. (PMID: 36012549)
Sci Rep. 2020 Jun 9;10(1):9362. (PMID: 32518242)
J Exp Med. 2009 Jun 8;206(6):1327-37. (PMID: 19451266)
Nanomedicine. 2018 Mar 13;14(4):1237-1248. (PMID: 29545216)
Am J Chin Med. 2019;47(5):933-957. (PMID: 31248265)
Crit Rev Food Sci Nutr. 2017 Feb 11;57(3):613-631. (PMID: 25675136)
Int J Mol Sci. 2021 Nov 22;22(22):. (PMID: 34830472)
Materials (Basel). 2021 Feb 24;14(5):. (PMID: 33668271)
Adv Mater. 2020 Feb;32(5):e1901979. (PMID: 31334581)
ACS Nano. 2018 Dec 26;12(12):11949-11962. (PMID: 30444603)
Chem Soc Rev. 2014 Jan 7;43(1):291-312. (PMID: 24121318)
Int J Mol Sci. 2021 Sep 16;22(18):. (PMID: 34576190)
Sci Rep. 2022 Feb 4;12(1):1959. (PMID: 35121783)
Free Radic Biol Med. 2010 Dec 1;49(11):1603-16. (PMID: 20840865)
Biotechnol J. 2021 Feb;16(2):e1900422. (PMID: 32618417)
Nanoscale Adv. 2019 Nov 6;1(12):4965-4971. (PMID: 36133106)
J Exp Med. 2018 Nov 5;215(11):2725-2736. (PMID: 30355614)
Int J Mol Sci. 2023 May 23;24(11):. (PMID: 37298090)
Colloids Surf B Biointerfaces. 2012 Jan 1;89:79-85. (PMID: 21962852)
Eur J Nutr. 2012 Feb;51(1):39-46. (PMID: 21445621)
Int J Nanomedicine. 2016 Apr 15;11:1537-47. (PMID: 27143876)
J Biol Chem. 2020 Feb 21;295(8):2495-2505. (PMID: 31937589)
فهرسة مساهمة: Keywords: Anti-metastasis; Graphene; HepG2; Hesperidin; JNK/SMAD4/MMP2; Radiation
المشرفين على المادة: 0 (graphene oxide)
0 (SMAD4 protein, human)
0 (MMP2 protein, human)
تواريخ الأحداث: Date Created: 20240521 Date Completed: 20240521 Latest Revision: 20240529
رمز التحديث: 20240529
مُعرف محوري في PubMed: PMC11109164
DOI: 10.1038/s41598-024-60347-5
PMID: 38773159
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-60347-5