دورية أكاديمية
CD133-targeted multifunctional nanomicelles for dual-modality imaging and synergistic high-intensity focus ultrasound (HIFU) ablation on pancreatic cancer in nude mice.
| العنوان: | CD133-targeted multifunctional nanomicelles for dual-modality imaging and synergistic high-intensity focus ultrasound (HIFU) ablation on pancreatic cancer in nude mice. |
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| المؤلفون: | Yao Y; Department of Ultrasound, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. jinger_28@sina.com., Zheng Y; Department of Ultrasound, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. jinger_28@sina.com., Wu M; Department of Ultrasound, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. jinger_28@sina.com., Gao Y; Department of Ultrasound, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. jinger_28@sina.com., Yu Q; Department of Ultrasound, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. jinger_28@sina.com., Liu M; Department of Ultrasound, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. jinger_28@sina.com., Luo X; Department of Ultrasound, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. jinger_28@sina.com., Wang R; Department of Ultrasound, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. jinger_28@sina.com., Jiang L; Department of Ultrasound, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. jinger_28@sina.com. |
| المصدر: | Journal of materials chemistry. B [J Mater Chem B] 2024 Jun 19; Vol. 12 (24), pp. 5884-5897. Date of Electronic Publication: 2024 Jun 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101598493 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-7518 (Electronic) Linking ISSN: 2050750X NLM ISO Abbreviation: J Mater Chem B Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Pancreatic Neoplasms*/diagnostic imaging , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/therapy , Mice, Nude* , AC133 Antigen*/metabolism , Micelles* , High-Intensity Focused Ultrasound Ablation*, Animals ; Mice ; Humans ; Cell Line, Tumor ; Fluorocarbons/chemistry ; Fluorocarbons/pharmacology ; Mice, Inbred BALB C ; Nanoparticles/chemistry |
| مستخلص: | Pancreatic cancer is an aggressive and highly fatal malignant tumor. Recent studies have shown that cancer stem cells (CSCs) play an important role in resisting current therapeutic modalities. Furthermore, CD133 is highly expressed in CSCs. High-intensity focused ultrasound (HIFU) is a promising non-invasive therapeutic strategy for unresectable pancreatic cancers. In our study, we synthesized targeted CD133 organosilane nanomicelles by encapsulating perfluorohexane (PFH). The CD133 antibody on the surface could specifically bind to CD133-positive pancreatic cancer cells and selectively concentrate in pancreatic cancer tumor tissues. PFH was introduced to improve the ablation effect of HIFU due to its liquid-gas phase transition properties. By combining with the dorsal skinfold window chamber model (DSWC) of pancreatic cancer in nude mice, multiphoton fluorescence microscopy was used to evaluate the targeting effect of nanomicelles on pancreatic cancer tumor tissue. These multifunctional nanomicelles synergistically affected HIFU treatment of pancreatic cancer, providing an integrated research platform for diagnosing and treating pancreatic cancer with HIFU. |
| المشرفين على المادة: | 0 (AC133 Antigen) 0 (Micelles) 0 (Fluorocarbons) FX3WJ41CMX (perflexane) |
| تواريخ الأحداث: | Date Created: 20240522 Date Completed: 20240619 Latest Revision: 20240628 |
| رمز التحديث: | 20240629 |
| DOI: | 10.1039/d4tb00091a |
| PMID: | 38775254 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2050-7518 |
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| DOI: | 10.1039/d4tb00091a |