دورية أكاديمية
Immune escape of B-cell lymphoblastic leukemic cells through a lineage switch to acute myeloid leukemia.
| العنوان: | Immune escape of B-cell lymphoblastic leukemic cells through a lineage switch to acute myeloid leukemia. |
|---|---|
| المؤلفون: | Bełdzińska-Gądek K; Department of Hematology and Transplantology, Medical University of Gdansk, Gdansk, Poland.; First Doctoral School, Medical University of Gdansk, Gdansk, Poland., Zarzycka E; Department of Hematology and Transplantology, Medical University of Gdansk, Gdansk, Poland., Pastuszak K; Department of Algorithms and System Modelling, Gdansk University of Technology, Gdansk, Poland.; Department of Translational Oncology, Medical University of Gdańsk, Gdansk, Poland.; Centre of Biostatistics and Bioinformatics, Medical University of Gdańsk, Gdansk, Poland., Borman K; Intercollegiate Biotechnology Doctoral School, University of Gdańsk and Medical University of Gdańsk, Gdansk, Poland., Lewandowski K; Laboratory of Hematology, Gdansk University Clinical Center, Gdansk, Poland., Zaucha JM; Department of Hematology and Transplantology, Medical University of Gdansk, Gdansk, Poland., Prejzner W; Department of Hematology and Transplantology, Medical University of Gdansk, Gdansk, Poland. |
| المصدر: | Leukemia & lymphoma [Leuk Lymphoma] 2024 Sep; Vol. 65 (9), pp. 1292-1302. Date of Electronic Publication: 2024 May 22. |
| نوع المنشور: | Journal Article; Case Reports; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Philadelphia, PA] : Taylor & Francis Original Publication: Chur ; New York : London, UK : Harwood Academic Publishers ; Distributed by STBS, 1989- |
| مواضيع طبية MeSH: | Cell Lineage*/genetics , Cell Lineage*/immunology , Leukemia, Myeloid, Acute*/diagnosis , Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/immunology , Leukemia, Myeloid, Acute*/pathology , Myeloid-Lymphoid Leukemia Protein*/genetics, Humans ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/immunology ; Gene Rearrangement/immunology ; Histone-Lysine N-Methyltransferase/genetics ; Immunophenotyping ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Tumor Escape/genetics ; Tumor Escape/immunology |
| مستخلص: | Acute leukemia (AL) with a lineage switch (LS) is associated with poor prognosis. The predisposing factors of LS are unknown, apart from KMT2A rearrangements that have been reported to be associated with LS. Herein, we present two cases and review all 104 published cases to identify risk factors for LS. Most of the patients (75.5%) experienced a switch from the lymphoid phenotype to the myeloid phenotype. Eighteen patients (17.0%) experienced a transformation from acute myelogenous leukemia (AML) to acute lymphoblastic leukemia (ALL). Forty-nine (46.2%) patients carried a KMT2A rearrangement. Most of the cases involved LS from B-cell ALL (B-ALL) to AML (59.4%), and 49 patients (46.2%) carried KMT2A -rearrangements. Forty patients (37.7%) received lineage-specific immunotherapy. Our findings suggest that the prevalence of KMT2A rearrangements together with the lineage-specific immunotherapy may trigger LS, which supports the thesis of the existence of leukemia stem cells that are capable of lymphoid or myeloid differentiation. |
| فهرسة مساهمة: | Keywords: Lineage switch; acute leukemia; immunotherapy |
| المشرفين على المادة: | EC 2.1.1.43 (Histone-Lysine N-Methyltransferase) 0 (KMT2A protein, human) 149025-06-9 (Myeloid-Lymphoid Leukemia Protein) |
| تواريخ الأحداث: | Date Created: 20240522 Date Completed: 20240829 Latest Revision: 20240913 |
| رمز التحديث: | 20240914 |
| DOI: | 10.1080/10428194.2024.2351194 |
| PMID: | 38775354 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1029-2403 |
|---|---|
| DOI: | 10.1080/10428194.2024.2351194 |