دورية أكاديمية
Loss of ATP-Sensitive Potassium Channel Expression and Function in the Nervous System Decreases Opioid Sensitivity in a High-Fat Diet-Fed Mouse Model of Diet-Induced Obesity.
| العنوان: | Loss of ATP-Sensitive Potassium Channel Expression and Function in the Nervous System Decreases Opioid Sensitivity in a High-Fat Diet-Fed Mouse Model of Diet-Induced Obesity. |
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| المؤلفون: | Fisher C; Department of Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota, Duluth, MN., Johnson K; Department of Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota, Duluth, MN., Moore M; Department of Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota, Duluth, MN., Sadrati A; Department of Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota, Duluth, MN., Janecek JL; Department of Surgery, University of Minnesota, St. Paul, MN., Graham ML; Department of Surgery, University of Minnesota, St. Paul, MN., Klein AH; Department of Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota, Duluth, MN.; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY. |
| المصدر: | Diabetes [Diabetes] 2024 Aug 01; Vol. 73 (8), pp. 1244-1254. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Alexandria, VA : American Diabetes Association Original Publication: [New York, American Diabetes Association] |
| مواضيع طبية MeSH: | Obesity*/metabolism , Diet, High-Fat*/adverse effects , KATP Channels*/metabolism , KATP Channels*/genetics , Potassium Channels, Inwardly Rectifying*/metabolism , Potassium Channels, Inwardly Rectifying*/genetics , Sulfonylurea Receptors*/metabolism , Sulfonylurea Receptors*/genetics, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Morphine/pharmacology ; Analgesics, Opioid/pharmacology ; Glyburide/pharmacology ; Disease Models, Animal |
| مستخلص: | During diabetes progression, β-cell dysfunction due to loss of potassium channels sensitive to ATP, known as KATP channels, occurs, contributing to hyperglycemia. The aim of this study was to investigate if KATP channel expression or activity in the nervous system was altered in a high-fat diet (HFD)-fed mouse model of diet-induced obesity. Expression of two KATP channel subunits, Kcnj11 (Kir6.2) and Abcc8 (SUR1), were decreased in the peripheral and central nervous system of mice fed HFD, which was significantly correlated with mechanical paw-withdrawal thresholds. HFD mice had decreased antinociception to systemic morphine compared with control diet (CON) mice, which was expected because KATP channels are downstream targets of opioid receptors. Mechanical hypersensitivity in HFD mice was exacerbated after systemic treatment with glyburide or nateglinide, KATP channel antagonists clinically used to control blood glucose levels. Upregulation of SUR1 and Kir6.2, through an adenovirus delivered intrathecally, increased morphine antinociception in HFD mice. These data present a potential link between KATP channel function and neuropathy during early stages of diabetes. There is a need for increased knowledge of how diabetes affects structural and molecular changes in the nervous system, including ion channels, to lead to the progression of chronic pain and sensory issues. (© 2024 by the American Diabetes Association.) |
| التعليقات: | Update of: bioRxiv. 2023 Sep 06:2023.09.06.556526. doi: 10.1101/2023.09.06.556526. (PMID: 37732180) |
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| معلومات مُعتمدة: | R01DA05187 United States DA NIDA NIH HHS; Academic Health Center Faculty Development Grant University of Minnesota |
| المشرفين على المادة: | 0 (KATP Channels) 0 (Potassium Channels, Inwardly Rectifying) 0 (Kir6.2 channel) 0 (Sulfonylurea Receptors) 0 (Abcc8 protein, mouse) 76I7G6D29C (Morphine) 0 (Analgesics, Opioid) SX6K58TVWC (Glyburide) |
| تواريخ الأحداث: | Date Created: 20240522 Date Completed: 20240719 Latest Revision: 20240724 |
| رمز التحديث: | 20240725 |
| مُعرف محوري في PubMed: | PMC11262047 |
| DOI: | 10.2337/db23-1030 |
| PMID: | 38776417 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1939-327X |
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| DOI: | 10.2337/db23-1030 |