دورية أكاديمية
The combined toxicity of polystyrene nano/micro-plastics and triphenyl phosphate (TPHP) on HepG2 cells.
| العنوان: | The combined toxicity of polystyrene nano/micro-plastics and triphenyl phosphate (TPHP) on HepG2 cells. |
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| المؤلفون: | Huang W; School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan, Guangdong 523808, China., Yang Y; School of Environment and Energy, South China University of Technology, Guangzhou, Guangdong 510006, China., Tang S; School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan, Guangdong 523808, China., Yin H; School of Environment and Energy, South China University of Technology, Guangzhou, Guangdong 510006, China. Electronic address: huayin@scut.edu.cn., Yu X; Guangdong Provincial Key Laboratory of Petrochemical Pollution Processes and Control, School of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming, Guangdong 525000, China., Yu Y; School of Environment and Energy, South China University of Technology, Guangzhou, Guangdong 510006, China. Electronic address: huayin@scut.edu.cn., Wei K; School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan, Guangdong 523808, China. |
| المصدر: | Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2024 Jul 01; Vol. 279, pp. 116489. Date of Electronic Publication: 2024 May 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Netherlands : Elsevier |
| مواضيع طبية MeSH: | Polystyrenes*/toxicity , Polystyrenes*/chemistry , Nanoparticles*/toxicity , Nanoparticles*/chemistry , Membrane Potential, Mitochondrial*/drug effects , Apoptosis*/drug effects , Flame Retardants*/toxicity , Microplastics*/toxicity , Reactive Oxygen Species*/metabolism, Humans ; Hep G2 Cells ; Particle Size ; Organophosphates/toxicity ; Water Pollutants, Chemical/toxicity ; Adsorption ; Plastics/toxicity |
| مستخلص: | Combined toxicity is a critical concern during the risk assessment of environmental pollutants. Due to the characteristics of strong hydrophobicity and large specific surface area, microplastics (MPs) and nanoplastics (NPs) have become potential carriers of organic pollutants that may pose a health risk to humans. The co-occurrence of organic pollutants and MPs would cause adverse effects on aquatic organism, while the information about combined toxicity induced by organophosphorus flame retardants and MPs on human cells was limited. This study aimed to reveal the toxicity effects of co-exposure to triphenyl phosphate (TPHP) and polystyrene (PS) particles with micron-size/nano-size on HepG2 cell line. The adsorption behaviors of TPHP on PS particles was observed, with the PS-NP exhibiting a higher adsorption capacity. The reactive oxygen species generation, mitochondrial membrane potential depolarization, lactate dehydrogenase release and cell apoptosis proved that PS-NPs/MPs exacerbated TPHP-induced cytotoxicity. The particle size of PS would affect the toxicity to HepG2 cells that PS-NP (0.07 μm) exhibited more pronounced combined toxicity than PS-MP (1 μm) with equivalent concentrations of TPHP. This study provides fundamental insights into the co-toxicity of TPHP and PS micro/nanoplastics in HepG2 cells, which is crucial for validating the potential risk of combined toxicity in humans. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Combined toxicity; HepG2 cells; Micro/nanoplastics; Polystyrene; Triphenyl phosphate |
| المشرفين على المادة: | 0 (Polystyrenes) YZE19Z66EA (triphenyl phosphate) 0 (Flame Retardants) 0 (Microplastics) 0 (Reactive Oxygen Species) 0 (Organophosphates) 0 (Water Pollutants, Chemical) 0 (Plastics) |
| تواريخ الأحداث: | Date Created: 20240522 Date Completed: 20240606 Latest Revision: 20240606 |
| رمز التحديث: | 20240607 |
| DOI: | 10.1016/j.ecoenv.2024.116489 |
| PMID: | 38776781 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2414 |
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| DOI: | 10.1016/j.ecoenv.2024.116489 |