دورية أكاديمية
أعرض في EDS

Synergistic Amelioration of Letrozole-induced Polycystic Ovary Syndrome in Rats: A Therapeutic Approach with Apple Cider Vinegar and Metformin Combination.

التفاصيل البيبلوغرافية
العنوان: Synergistic Amelioration of Letrozole-induced Polycystic Ovary Syndrome in Rats: A Therapeutic Approach with Apple Cider Vinegar and Metformin Combination.
المؤلفون: Danduga RCSR; Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, 400056, India. ravichandra.pharma2262@gmail.com., Kurapati AS; Department of Pharmacology, Acharya Nagarjuna University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, 522510, India., Shaik RA; Department of Pharmacology, Acharya Nagarjuna University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, 522510, India., Kola PK; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA., Konidala SK; Department of Pharmaceutical Sciences, School of Biotechnology and Pharmaceutical Sciences, Vignan's Foundation for Sciences, Technology, and Research, Vadlamudi, Guntur, 522213, India., Varada HB; Department of Pharmacology, Acharya Nagarjuna University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, 522510, India.
المصدر: Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2024 Sep; Vol. 31 (9), pp. 2861-2876. Date of Electronic Publication: 2024 May 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101291249 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-7205 (Electronic) Linking ISSN: 19337191 NLM ISO Abbreviation: Reprod Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: 2020- : [New York] : Springer
Original Publication: Thousand Oaks, Calif. : Sage
مواضيع طبية MeSH: Polycystic Ovary Syndrome*/chemically induced , Polycystic Ovary Syndrome*/drug therapy , Polycystic Ovary Syndrome*/pathology , Letrozole*/administration & dosage , Metformin*/pharmacology , Metformin*/administration & dosage , Rats, Wistar* , Acetic Acid* , Oxidative Stress*/drug effects , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/administration & dosage , Drug Synergism* , Drug Therapy, Combination*, Animals ; Female ; Rats ; Ovary/drug effects ; Ovary/pathology ; Ovary/metabolism ; Malus/chemistry ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Aromatase Inhibitors/pharmacology ; Aromatase Inhibitors/administration & dosage ; Estrous Cycle/drug effects
مستخلص: The present study was conducted to evaluate the combination effect of apple cider vinegar (ACV) and metformin against letrozole-induced polycystic ovary syndrome (PCOS). Female Wistar rats were administered letrozole (1 mg/kg/day, p.o) for 21 days, except for the control group of animals. On the 22nd day, PCOS-induced animals were segregated into 4 groups and administered with CMC, ACV, metformin, and a combination of ACV and metformin, respectively. The treatments were continued for 15 days, and on the 36th day, all the animals were sacrificed for biochemical (blood glucose, lipid profile), hormonal (sex hormones and adiponectin), and pro-inflammatory mediator estimations in blood samples. The ovarian tissue samples were used for oxidative stress parameters and histological alterations. The PCOS control animals showed a significant alteration in the estrous cycle. The administration of letrozole resulted in the alteration of hormonal balance and elevation of body weights, glycemic state, lipid profile, pro-inflammatory mediators in serum, and oxidative stress in ovarian samples. Individual treatment groups and combination treatment groups reversed the letrozole-induced alterations in PCOS animals, and more promising results were observed with combination therapy than with individual treatment groups. Further, the therapeutic potential of the combination treatment group was also confirmed by the histological observations in the ovarian samples. The study showed that the combination of ACV and metformin significantly alleviated letrozole-induced PCOS complications in rats. This might have been achieved by mitigating the hormonal imbalance, pro-inflammatory, hyperglycemic, and hyperlipidemic states in serum, and oxidative stress in the ovary samples.
(© 2024. The Author(s), under exclusive licence to Society for Reproductive Investigation.)
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فهرسة مساهمة: Keywords: Adiponectin; Apple cider vinegar; Histological alterations; Metformin; Oxidative stress; PCOS; Pro-inflammatory mediators; Sex hormones
المشرفين على المادة: 7LKK855W8I (Letrozole)
9100L32L2N (Metformin)
Q40Q9N063P (Acetic Acid)
0 (Hypoglycemic Agents)
0 (Blood Glucose)
0 (Aromatase Inhibitors)
تواريخ الأحداث: Date Created: 20240522 Date Completed: 20240913 Latest Revision: 20240925
رمز التحديث: 20240925
DOI: 10.1007/s43032-024-01545-4
PMID: 38777948
قاعدة البيانات: MEDLINE
الوصف
تدمد:1933-7205
DOI:10.1007/s43032-024-01545-4