دورية أكاديمية
The salt sensitivity of Drd4-null mice is associated with the upregulations of sodium transporters in kidneys.
| العنوان: | The salt sensitivity of Drd4-null mice is associated with the upregulations of sodium transporters in kidneys. |
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| المؤلفون: | Zhang M; The Core Laboratory for Clinical Research, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China.; Department of Nephrology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China., Liu M; The Core Laboratory for Clinical Research, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China., Wang W; The Core Laboratory for Clinical Research, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China., Ren Z; The Core Laboratory for Clinical Research, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China., Wang P; The Core Laboratory for Clinical Research, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China., Xue Y; The Core Laboratory for Clinical Research, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China., Wang X; The Core Laboratory for Clinical Research, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China. xiaoyan.wang@benqmedicalcenter.com.; Department of Nephrology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China. xiaoyan.wang@benqmedicalcenter.com. |
| المصدر: | Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2024 Aug; Vol. 47 (8), pp. 2144-2156. Date of Electronic Publication: 2024 May 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9307690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1348-4214 (Electronic) Linking ISSN: 09169636 NLM ISO Abbreviation: Hypertens Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2009- : London : Nature Publishing Group Original Publication: Toyonaka, Japan : The Society, c1992-2003 |
| مواضيع طبية MeSH: | Kidney*/metabolism , Mice, Knockout* , Receptors, Dopamine D4*/genetics , Receptors, Dopamine D4*/metabolism, Animals ; Mice ; Up-Regulation ; Sodium Chloride, Dietary ; Solute Carrier Family 12, Member 1/metabolism ; Male ; Hypertension/metabolism ; Hypertension/genetics ; Sodium-Hydrogen Exchanger 3/metabolism ; Sodium-Hydrogen Exchanger 3/genetics ; Blood Pressure/physiology ; Epithelial Sodium Channels/metabolism ; Epithelial Sodium Channels/genetics ; Sodium-Hydrogen Exchangers/metabolism ; Sodium-Hydrogen Exchangers/genetics ; Mice, Inbred C57BL |
| مستخلص: | To explore the mechanism of the hypertension in dopamine receptor-4 (Drd4) null mice, we determined the salt sensitivity and renal sodium transport proteins in Drd4 -/- and Drd4 +/+ mice with varied salt diets. On normal NaCl diet (NS), mean arterial pressures (MAP, telemetry) were higher in Drd4 -/- than Drd4 +/+ ; Low NaCl diet (LS) tended to decrease MAP in both strains; high NaCl diet (HS) elevated MAP with sodium excretion decreased and pressure-natriuresis curve shifted to right in Drd4 -/- relative to Drd4 +/+ mice. Drd4 -/- mice exhibited increased renal sodium-hydrogen exchanger 3 (NHE3), sodium-potassium-2-chloride cotransporter (NKCC2), sodium-chloride cotransporter (NCC), and outer medullary α-epithelial sodium channel (αENaC) on NS, decreased NKCC2, NCC, αENaC, and αNa + -K + -ATPase on LS, and increased αENaC on HS. NKCC2, NCC, αENaC, and αNa + -K + -ATPase in plasma membrane were greater in Drd4 -/- than in Drd4 +/+ mice with HS. D4R was expressed in proximal and distal convoluted tubules, thick ascending limbs, and outer medullary collecting ducts and colocalized with NKCC2 and NCC. The phosphorylation of NKCC2 was enhanced but ubiquitination was reduced in the KO mice. There were no differences between the mouse strains in serum aldosterone concentrations and urinary dopamine excretions despite their changes with diets. The mRNA expressions of renal NHE3, NKCC2, NCC, and αENaC on NS were not altered in Drd4 -/- mice. Thus, increased protein expressions of NHE3, NKCC2, NCC and αENaC are associated with hypertension in Drd4 -/- mice; increased plasma membrane protein expression of NKCC2, NCC, αENaC, and αNa + -K + -ATPase may mediate the salt sensitivity of Drd4 -/- mice. (© 2024. The Author(s), under exclusive licence to The Japanese Society of Hypertension.) |
| التعليقات: | Comment in: Hypertens Res. 2024 Aug 9. doi: 10.1038/s41440-024-01832-2. (PMID: 39122789) |
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| فهرسة مساهمة: | Keywords: Dopamine receptor; Hypertension; Renal Na+ transporters; Sodium excretion; Ubiquitination |
| المشرفين على المادة: | 137750-34-6 (Receptors, Dopamine D4) 0 (Sodium Chloride, Dietary) 0 (Solute Carrier Family 12, Member 1) 0 (Sodium-Hydrogen Exchanger 3) 0 (Slc9a3 protein, mouse) 0 (Epithelial Sodium Channels) 0 (Slc12a1 protein, mouse) 0 (Sodium-Hydrogen Exchangers) |
| تواريخ الأحداث: | Date Created: 20240522 Date Completed: 20240804 Latest Revision: 20240809 |
| رمز التحديث: | 20240812 |
| DOI: | 10.1038/s41440-024-01724-5 |
| PMID: | 38778170 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1348-4214 |
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| DOI: | 10.1038/s41440-024-01724-5 |