دورية أكاديمية
Immunotherapy in the neoadjuvant treatment of gastrointestinal tumors: is the time ripe?
العنوان: | Immunotherapy in the neoadjuvant treatment of gastrointestinal tumors: is the time ripe? |
---|---|
المؤلفون: | Gervaso L; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IEO IRCCS, European Institute of Oncology, Milano, Italy.; Molecular Medicine Program, University of Pavia, Pavia, Lombardia, Italy., Ciardiello D; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IEO IRCCS, European Institute of Oncology, Milano, Italy., Oliveira RA; Clinical Oncology, Londrina Cancer Hospital, Londrina, Paranà, Brazil., Borghesani M; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IEO IRCCS, European Institute of Oncology, Milano, Italy., Guidi L; Division of New Drugs and Early Drug Development for Innovative Therapies, IEO IRCCS, European Institute of Oncology, Milano, Italy., Benini L; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IEO IRCCS, European Institute of Oncology, Milano, Italy., Algeri L; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IEO IRCCS, European Institute of Oncology, Milano, Italy., Spada F; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IEO IRCCS, European Institute of Oncology, Milano, Italy., Zampino MG; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IEO IRCCS, European Institute of Oncology, Milano, Italy., Cella CA; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IEO IRCCS, European Institute of Oncology, Milano, Italy., Fazio N; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IEO IRCCS, European Institute of Oncology, Milano, Italy nicola.fazio@ieo.it. |
المصدر: | Journal for immunotherapy of cancer [J Immunother Cancer] 2024 May 23; Vol. 12 (5). Date of Electronic Publication: 2024 May 23. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2020- : London, United Kingdom : BMJ Publishing Group Ltd. Original Publication: London : BioMed Central, 2013- |
مواضيع طبية MeSH: | Neoadjuvant Therapy*/methods , Gastrointestinal Neoplasms*/drug therapy , Gastrointestinal Neoplasms*/therapy , Immunotherapy*/methods, Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immune Checkpoint Inhibitors/pharmacology ; Microsatellite Instability |
مستخلص: | Immune checkpoint inhibitors (ICIs) revolutionized the management of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancers. Based on notable results observed in the metastatic setting, several clinical trials investigated ICIs as neoadjuvant treatment (NAT) for localized dMMR/MSI-H GI cancers, achieving striking results in terms of clinical and pathological responses and creating the opportunity to spare patients from neoadjuvant chemotherapy and/or radiotherapy and even surgical resection. Nevertheless, these impressive findings are mainly derived from small proof of concept phase II studies and there are still several open questions to address. Moreover, dMMR/MSI-H represents a limited subgroup accounting for less than 10% of GI cancers. Consequently, many efforts have been produced to investigate neoadjuvant ICIs also in mismatch repair-proficient/microsatellite stable (MSS) cancers, considering the potential synergistic effect in combining immune-targeted agents with standard therapies such as chemo and/or radiotherapy. However, results for combining ICIs to the standard of care in the unselected population are still unsatisfactory, without improvements in event-free survival in esophago-gastric adenocarcinoma for the addition of pembrolizumab to chemotherapy, and sometimes limited benefit in patients with locally advanced rectal cancer. Therefore, a major challenge will be to identify among the heterogenous spectrum of this disease, those patients that could take advantage of neoadjuvant immunotherapy and deliver the most effective treatment. In this review we discuss the rationale of NAT in GI malignancies, summarize the available evidence regarding the completed trials that evaluated this treatment strategy in both MSI-H and MSS tumors. Finally, we discuss ongoing studies and future perspectives to render neoadjuvant immunotherapy another arrow in the quiver for the treatment of locally advanced GI tumors. Competing Interests: Competing interests: DC received travel support from Sanofi, BMS and Merck KgA. NF declares Personal Financial Interests for ADACAP, Ipsen (Invited speaker), for ADACAP, Merck, MSD, Novartis, Pfizer, Boehringer (Advisory Board); Institutional Financial Interests: local PI of trials for 4SC, Astellas, Beigene, Fibrogen, Incyte, Ipsen, Nucana; research grants from ADACAP, Ipsen, MSD, Merck. Other Authors declare no conflict of interests. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.) |
References: | Future Oncol. 2019 Mar;15(9):943-952. (PMID: 30777447) Lancet Gastroenterol Hepatol. 2022 Jan;7(1):38-48. (PMID: 34688374) Lancet Gastroenterol Hepatol. 2023 May;8(5):422-431. (PMID: 36870360) Nat Rev Clin Oncol. 2019 Mar;16(3):151-167. (PMID: 30523282) N Engl J Med. 2022 Feb 3;386(5):449-462. (PMID: 35108470) Lancet Oncol. 2017 Mar;18(3):336-346. (PMID: 28190762) Lancet Oncol. 2021 Jan;22(1):29-42. (PMID: 33301740) J Natl Compr Canc Netw. 2023 Jan;21(1):60-66.e5. (PMID: 36630898) Oncogene. 2023 Oct;42(44):3252-3259. (PMID: 37731056) Cancer Discov. 2016 Dec;6(12):1382-1399. (PMID: 27663893) N Engl J Med. 2004 Oct 21;351(17):1731-40. (PMID: 15496622) Clin Transl Oncol. 2023 Nov;25(11):3287-3295. (PMID: 37084152) Science. 2011 Mar 25;331(6024):1565-70. (PMID: 21436444) Ann Oncol. 2019 Aug 1;30(8):1232-1243. (PMID: 31056702) Clin Cancer Res. 2021 Jul 1;27(13):3714-3724. (PMID: 33926917) BMC Cancer. 2022 Mar 15;22(1):274. (PMID: 35291966) Cancer Treat Rev. 2015 Jun;41(6):503-10. (PMID: 25872878) J Immunother Cancer. 2021 Nov;9(11):. (PMID: 34725214) N Engl J Med. 2020 Dec 3;383(23):2207-2218. (PMID: 33264544) Annu Rev Immunol. 2008;26:677-704. (PMID: 18173375) J Clin Oncol. 2023 Jan 10;41(2):255-265. (PMID: 35969830) Ann Surg Oncol. 2023 Jun;30(6):3594-3602. (PMID: 36795255) Br J Radiol. 1953 May;26(305):234-41. (PMID: 13042090) Ann Oncol. 2022 Oct;33(10):1052-1060. (PMID: 35764271) J Clin Oncol. 2015 Jun 10;33(17):1889-94. (PMID: 25667295) Cancer Cell Int. 2020 Jan 13;20:16. (PMID: 31956294) Arch Toxicol. 2015 Jun;89(6):899-921. (PMID: 25701956) Cancer Treat Rev. 2019 Jun;76:22-32. (PMID: 31079031) JAMA Oncol. 2021 Aug 01;7(8):1225-1230. (PMID: 34196693) Curr Opin Immunol. 2014 Apr;27:16-25. (PMID: 24531241) J Clin Oncol. 2020 Jan 1;38(1):11-19. (PMID: 31725351) Lancet Oncol. 2010 Sep;11(9):835-44. (PMID: 20692872) Ann Oncol. 2020 Oct;31(10):1291-1305. (PMID: 32702383) J Clin Oncol. 2020 Jan 1;38(1):1-10. (PMID: 31682550) JAMA Oncol. 2017 Sep 01;3(9):1197-1203. (PMID: 28241187) Front Immunol. 2023 May 30;14:1177085. (PMID: 37325652) Nat Med. 2020 Apr;26(4):566-576. (PMID: 32251400) Immunity. 2016 Mar 15;44(3):698-711. (PMID: 26982367) J Clin Oncol. 2023 Mar 10;41(8):1541-1552. (PMID: 36657089) Science. 2016 Mar 25;351(6280):1463-9. (PMID: 26940869) J Clin Oncol. 2021 Feb 20;39(6):642-651. (PMID: 33356421) Nat Rev Cancer. 2012 Mar 15;12(4):298-306. (PMID: 22419253) Semin Cancer Biol. 2022 Nov;86(Pt 2):834-850. (PMID: 35671877) Lancet Oncol. 2021 Jan;22(1):43-50. (PMID: 33316218) Nat Rev Immunol. 2020 Nov;20(11):651-668. (PMID: 32433532) J Investig Med. 2021 Mar;69(3):689-696. (PMID: 33443046) Lancet Oncol. 2017 Sep;18(9):1182-1191. (PMID: 28734759) Dig Liver Dis. 2022 Oct;54(10):1335-1341. (PMID: 35907691) Ann Transl Med. 2021 Jan;9(1):73. (PMID: 33553366) Ther Adv Med Oncol. 2021 Sep 1;13:17588359211029559. (PMID: 34484429) JAMA Oncol. 2018 May 10;4(5):e180013. (PMID: 29543932) Future Oncol. 2022 Jun;18(20):2465-2473. (PMID: 35535555) N Engl J Med. 2022 Jun 23;386(25):2363-2376. (PMID: 35660797) Future Oncol. 2021 Apr;17(10):1143-1153. (PMID: 33533655) Nat Med. 2018 Nov;24(11):1655-1661. (PMID: 30297911) Lancet. 2019 May 11;393(10184):1948-1957. (PMID: 30982686) N Engl J Med. 2012 May 31;366(22):2074-84. (PMID: 22646630) Lancet. 2021 Jul 3;398(10294):27-40. (PMID: 34102137) Lancet Oncol. 2021 May;22(5):702-715. (PMID: 33862000) |
فهرسة مساهمة: | Keywords: Gastrointestinal Neoplasms; Immune Checkpoint Inhibitors; Immunotherapy; Programmed Cell Death 1 Receptor; Radiotherapy |
المشرفين على المادة: | 0 (Immune Checkpoint Inhibitors) |
تواريخ الأحداث: | Date Created: 20240523 Date Completed: 20240523 Latest Revision: 20240606 |
رمز التحديث: | 20240607 |
مُعرف محوري في PubMed: | PMC11116869 |
DOI: | 10.1136/jitc-2023-008027 |
PMID: | 38782539 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!