دورية أكاديمية
أعرض في EDS

A Novel image processing technique for weighted particle size distribution assessment.

التفاصيل البيبلوغرافية
العنوان: A Novel image processing technique for weighted particle size distribution assessment.
المؤلفون: Latreille PL; Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada., Pazhayattil AB; Itaan Pharma Inc., Frederick, MD, USA., Turner S; Capcium Inc., Pointe-Claire, Quebec, Canada., Talwar N; Capcium Inc., Pointe-Claire, Quebec, Canada.
المصدر: Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2024 Jun; Vol. 50 (6), pp. 550-560. Date of Electronic Publication: 2024 May 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 7802620 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5762 (Electronic) Linking ISSN: 03639045 NLM ISO Abbreviation: Drug Dev Ind Pharm Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Informa Healthcare
Original Publication: New York, Dekker.
مواضيع طبية MeSH: Particle Size* , Powders*/chemistry , Image Processing, Computer-Assisted*/methods , Chemistry, Pharmaceutical*/methods, Technology, Pharmaceutical/methods ; Drug Compounding/methods ; Excipients/chemistry ; Software
مستخلص: The objective of the study was to create a reliable method that could be used to evaluate the particle size distribution of samples and pre-mixes in real-world situations, particularly those consisting of typical formulation blends. The goal was to use this method to assess the uniformity of the samples and ensure that they met the required quality standards. The researchers aimed to create a method that could be easily incorporated into the manufacturing process, providing a practical and efficient solution. This study demonstrates the use of ImageJ software to analyze the particle size distribution (PSD) of powders. The technique produces qualitative data from microscopy images and quantitative data from analysis of parameters including average diameter, D 10 , D 50 , D 90 , and standard deviation. The method was tested with various treatments, showing differentiating outcomes in all cases. The alternate technique provides a rapid and cost-effective method for PSD analysis, surpassing the limitations of sieve analysis. Extensive testing of the method, using a variety of sample types, including typical formulation blends, was performed. The results suggest that the method can effectively assess the morphology of changing materials during batch manufacturing and characterize uniformity in blends. The methodology has the capability to identify attributes related to PSD that are typically required to be monitored during manufacturing. The technique allows for accurate and reliable quantification of the attributes through image capture technology. The technique has future potential and has important implications for material science, powder rheology, pharmaceutical formulation development, and continual process monitoring.
فهرسة مساهمة: Keywords: Characterization; formulation; particle size distribution; powder blend; test method
Local Abstract: [plain-language-summary] [Figure: see text]A Novel Image Processing Technique for Weighted Particle Size Distribution Assessment.
المشرفين على المادة: 0 (Powders)
0 (Excipients)
تواريخ الأحداث: Date Created: 20240524 Date Completed: 20240702 Latest Revision: 20240702
رمز التحديث: 20240703
DOI: 10.1080/03639045.2024.2358366
PMID: 38785352
قاعدة البيانات: MEDLINE
كن أول من يترك تعليقا!
يجب تسجيل دخولك أولا