دورية أكاديمية
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Morphological evidence for the potential protective effects of curcumin and Garcinia kola against diabetes in the rat hippocampus.

التفاصيل البيبلوغرافية
العنوان: Morphological evidence for the potential protective effects of curcumin and Garcinia kola against diabetes in the rat hippocampus.
المؤلفون: Denizci E; Department of Histology and Embryology, Ondokuz Mayıs University, Samsun 55139, Turkey., Altun G; Department of Histology and Embryology, Ondokuz Mayıs University, Samsun 55139, Turkey., Kaplan S; Department of Histology and Embryology, Ondokuz Mayıs University, Samsun 55139, Turkey; Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania. Electronic address: skaplan@omu.edu.tr.
المصدر: Brain research [Brain Res] 2024 Sep 15; Vol. 1839, pp. 149020. Date of Electronic Publication: 2024 May 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Curcumin*/pharmacology , Rats, Wistar* , Hippocampus*/drug effects , Hippocampus*/pathology , Garcinia kola* , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/pathology, Animals ; Male ; Rats ; Neuroprotective Agents/pharmacology ; Plant Extracts/pharmacology
مستخلص: This research investigated the effects of sciatic nerve transection and diabetes on the hippocampus, and the protective effects of Garcinia kola and curcumin. Thirty-five adults male Wistar albino rats were divided into five groups: a control group (Cont), a transected group (Sham group), a transected + diabetes mellitus group (DM), a transected + diabetes mellitus + Garcinia kola group (DM + GK), and a transected + DM + curcumin group (DM + Cur), each containing seven animals. The experimental diabetes model was created with the intraperitoneal injection of a single dose of streptozotocin. No procedure was applied to the Cont group, while sciatic nerve transection was performed on the other groups. Garcinia kola was administered to the rats in DM + GK, and curcumin to those in DM + Cur. Cardiac perfusion was performed at the end of the experimental period. Brain tissues were dissected for stereological, histopathological, and immunohistochemical evaluations. The volume ratios of hippocampal layers to the entire hippocampus volume were compared between the groups. Anti-S100, anti-caspase 3, and anti-SOX 2 antibodies were used for immunohistochemical analysis. No statistically significant difference was observed in the volume ratios of the four hippocampal layers. However, the volume ratio of the stratum lucidum was higher in the Sham, DM, and DM + Cur groups compared to the Cont group. While curcumin exhibited a protective effect on hippocampal tissue following diabetes induction, Garcinia kola had only a weak protective effect. Increased cell density and nuclear deterioration due to diabetes and nerve transection can be partially ameliorated by treatment with Garcinia kola and curcumin.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Curcumin; Diabetes; Garcinia kola; Hippocampus; Sciatic nerve transection; Stereology
المشرفين على المادة: IT942ZTH98 (Curcumin)
0 (Neuroprotective Agents)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20240524 Date Completed: 20240613 Latest Revision: 20240613
رمز التحديث: 20240614
DOI: 10.1016/j.brainres.2024.149020
PMID: 38788929
قاعدة البيانات: MEDLINE
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