دورية أكاديمية
Updates in Translational Science for Esophageal and Gastric Cancers.
| العنوان: | Updates in Translational Science for Esophageal and Gastric Cancers. |
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| المؤلفون: | Hompe ED; Division of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Austen 7, Boston, MA 02114, ISA., Sachdeva UM; Division of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit Street, Austen 7, Boston, MA 02114, ISA; Department of Surgery, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: uma.sachdeva@mgh.harvard.edu. |
| المصدر: | Surgical oncology clinics of North America [Surg Oncol Clin N Am] 2024 Jul; Vol. 33 (3), pp. 571-581. Date of Electronic Publication: 2024 Jan 20. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Saunders Country of Publication: United States NLM ID: 9211789 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-5042 (Electronic) Linking ISSN: 10553207 NLM ISO Abbreviation: Surg Oncol Clin N Am Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia : Saunders, c1992- |
| مواضيع طبية MeSH: | Esophageal Neoplasms*/genetics , Esophageal Neoplasms*/therapy , Esophageal Neoplasms*/pathology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/therapy , Stomach Neoplasms*/pathology , Translational Science, Biomedical*/methods, Animals ; Humans ; Organoids ; Precision Medicine/methods ; Translational Research, Biomedical/methods ; Tumor Microenvironment |
| مستخلص: | In this article, the authors summarize the current state of translational science for esophageal and gastric cancers. The available targeted therapies, immunotherapies, and recently discovered molecular targets are reviewed. The authors introduce circulating tumor deoxyribonucleic acid and its promise as a biomarker to detect disease recurrence. The authors present patient-derived organoids as a new model for studying carcinogenesis and treatment responses. Finally, we discuss the implications of organoid models for precision oncology and describe exciting new work applying gene editing technology to organoids and studying tumor-microenvironment interactions using 3-dimensional co-culture systems. Competing Interests: Disclosure E.D. Hompe and U.M. Sachdeva have no disclosures to report. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Circulating tumor DNA; Molecular targets; Patient-derived organoids; Precision oncology |
| تواريخ الأحداث: | Date Created: 20240524 Date Completed: 20240524 Latest Revision: 20240625 |
| رمز التحديث: | 20240626 |
| DOI: | 10.1016/j.soc.2023.12.022 |
| PMID: | 38789199 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1558-5042 |
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| DOI: | 10.1016/j.soc.2023.12.022 |