دورية أكاديمية
أعرض في EDS

Molecular Profile of Important Genes for Radiogenomics in the Amazon Indigenous Population.

التفاصيل البيبلوغرافية
العنوان: Molecular Profile of Important Genes for Radiogenomics in the Amazon Indigenous Population.
المؤلفون: de Lima MC; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil., de Castro CC; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil., Aguiar KEC; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil., Monte N; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil., Nunes GGDC; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil., Costa ACAD; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil., Rodrigues JCG; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil., Guerreiro JF; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.; Laboratory of Human and Medical Genetics, Federal University of Pará, Belém 66075-110, PA, Brazil., Ribeiro-Dos-Santos Â; Laboratory of Human and Medical Genetics, Federal University of Pará, Belém 66075-110, PA, Brazil., Assumpção PP; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil., Burbano RMR; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil., Fernandes MR; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil., Dos Santos SEB; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.; Laboratory of Human and Medical Genetics, Federal University of Pará, Belém 66075-110, PA, Brazil., Dos Santos NPC; Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
المصدر: Journal of personalized medicine [J Pers Med] 2024 Apr 30; Vol. 14 (5). Date of Electronic Publication: 2024 Apr 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2011-
مستخلص: Radiotherapy is focused on the tumor but also reaches healthy tissues, causing toxicities that are possibly related to genomic factors. In this context, radiogenomics can help reduce the toxicity, increase the effectiveness of radiotherapy, and personalize treatment. It is important to consider the genomic profiles of populations not yet studied in radiogenomics, such as the indigenous Amazonian population. Thus, our objective was to analyze important genes for radiogenomics, such as ATM , TGFB1 , RAD51 , AREG , XRCC4 , CDK1, MEG3 , PRKCE , TANC1 , and KDR , in indigenous people and draw a radiogenomic profile of this population. The NextSeq 500 ® platform was used for sequencing reactions; for differences in the allelic frequency between populations, Fisher's Exact Test was used. We identified 39 variants, 2 of which were high impact: 1 in KDR (rs41452948) and another in XRCC4 (rs1805377). We found four modifying variants not yet described in the literature in PRKCE . We did not find any variants in TANC1 -an important gene for personalized medicine in radiotherapy-that were associated with toxicities in previous cohorts, configuring a protective factor for indigenous people. We identified four SNVs (rs664143, rs1801516, rs1870377, rs1800470) that were associated with toxicity in previous studies. Knowing the radiogenomic profile of indigenous people can help personalize their radiotherapy.
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فهرسة مساهمة: Keywords: exome; genetic variants; indigenous population; oncology; radiogenomics; radiotherapy
تواريخ الأحداث: Date Created: 20240525 Latest Revision: 20240527
رمز التحديث: 20240527
مُعرف محوري في PubMed: PMC11122349
DOI: 10.3390/jpm14050484
PMID: 38793065
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-4426
DOI:10.3390/jpm14050484