دورية أكاديمية
أعرض في EDS

The role of dietary fats on cognition and sarcopenia in the elderly.

التفاصيل البيبلوغرافية
العنوان: The role of dietary fats on cognition and sarcopenia in the elderly.
المؤلفون: Wang X; School of Public Health, Capital Medical University, Beijing, China., Qi C; School of Public Health, Capital Medical University, Beijing, China., Li X; Department of Geriatrics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China., Li D; School of Public Health, Capital Medical University, Beijing, China., Ding H; School of Public Health, Capital Medical University, Beijing, China., Shen J; School of Public Health, Capital Medical University, Beijing, China., Liu Y; School of Public Health, Capital Medical University, Beijing, China., Xi Y; School of Public Health, Capital Medical University, Beijing, China. Email: xiaoer711@163.com.
المصدر: Asia Pacific journal of clinical nutrition [Asia Pac J Clin Nutr] 2024 Jun; Vol. 33 (2), pp. 272-282.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Qingdao University Country of Publication: China NLM ID: 9440304 Publication Model: Print Cited Medium: Internet ISSN: 1440-6047 (Electronic) Linking ISSN: 09647058 NLM ISO Abbreviation: Asia Pac J Clin Nutr Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : Qingdao : Qingdao University
Original Publication: London, UK : Published for the Asia Pacific Clinical Nutrition Society by Smith-Gordon,
مواضيع طبية MeSH: Sarcopenia*/prevention & control , Cognition* , Dietary Fats*/administration & dosage , Cognitive Dysfunction*/prevention & control, Humans ; Aged ; Male ; Female ; Aged, 80 and over ; Middle Aged ; Body Composition
مستخلص: Background and Objectives: To elucidate the role of dietary fats on the relationship between mild cognitive impairment and sarcopenia and help identifying and preventing the decline of cognitive and muscle function in elderly individuals.
Methods and Study Design: The study conducted involving a group of 1812 individuals between the ages of 61 and 92. Body composition and BMR were assessed by bioelectrical impedance analysis. Cognitive function and dietary nutrition were evaluated by neuropsychological assessments and questionnaire of food intake frequency. Lipidomics analysis was performed using UHPLC-Qtrap-MS/MS.
Results: MCI and SA are mutual influencing factors, lower intake of MUFA, PUFA and higher intake of fat was associated with cognitive dysfunction and/or SA (p < 0.05). PUFA was important for MCI combined with SA (Compared with Q1, Q4 OR: 0.176, 95%CI: 0.058,0.533). Lipidomics analysis revealed that triacylglycerol (TAG) contain more carbon chains with saturated double bonds may be closely related to cognitive impairment and the progression of SA (p < 0.05). While, DAG with carbon chains of unsaturated double bonds is opposite.
Conclusions: Insufficient intake of unsaturated fatty acids was associated with the development of cognitive decline and the progression of SA. MUFA affecting muscle health, fats and PUFA has a greater impact on MCI combined with SA. Less MUFA intake and increasing saturated double-bonded fatty acid intake might be the key factors on promoting cognitive impairment and SA in the elderly. They have the potential to serve as prospective biomarkers indicating a higher risk of cognitive decline and/or SA in the elderly population.
Competing Interests: The authors declare no conflict of interest
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معلومات مُعتمدة: 82273620 National Natural Science Foundation of China; 81973018 National Natural Science Foundation of China
فهرسة مساهمة: Keywords: dietary fats; lipidomics; mild cognitive impairment; sarcopenia; the elderly
المشرفين على المادة: 0 (Dietary Fats)
تواريخ الأحداث: Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240615
رمز التحديث: 20240615
مُعرف محوري في PubMed: PMC11170001
DOI: 10.6133/apjcn.202406_33(2).0012
PMID: 38794985
قاعدة البيانات: MEDLINE
الوصف
تدمد:1440-6047
DOI:10.6133/apjcn.202406_33(2).0012