دورية أكاديمية
Platelet-rich fibrin as an apical barrier for MTA placement in the treatment of teeth with open apices: a pilot study.
| العنوان: | Platelet-rich fibrin as an apical barrier for MTA placement in the treatment of teeth with open apices: a pilot study. |
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| المؤلفون: | Pham VK; University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam. khoapv@ump.edu.vn., Pham TL; University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Pham AT; University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Le HL; University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Tran TB; University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Huynh KK; University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Tran NM; University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Tran TL; University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Tran MH; National Hospital of Odonto-Stomatology, Ho Chi Minh City, Vietnam., Tran TA; National Hospital of Odonto-Stomatology, Ho Chi Minh City, Vietnam., Nguyen TT; Tra Vinh University, Tra Vinh City, Vietnam., Nguyen NP; Van Lang University, Ho Chi Minh City, Vietnam. |
| المصدر: | Journal of translational medicine [J Transl Med] 2024 May 25; Vol. 22 (1), pp. 498. Date of Electronic Publication: 2024 May 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, 2003- |
| مواضيع طبية MeSH: | Platelet-Rich Fibrin*/metabolism , Aluminum Compounds*/therapeutic use , Silicates*/therapeutic use , Calcium Compounds*/therapeutic use , Tooth Apex*/pathology , Tooth Apex*/diagnostic imaging, Humans ; Pilot Projects ; Female ; Male ; Adult ; Drug Combinations ; Middle Aged ; Oxides/therapeutic use ; Periapical Periodontitis/therapy ; Periapical Periodontitis/diagnostic imaging |
| مستخلص: | Objective: The aim of the present pilot study was to assess the effectiveness of the platelet-rich fibrin (PRF) apical barrier for the placement of MTA for the treatment of teeth with periapical lesions and open apices. Methods: A total of thirty teeth on twenty-eight patients with open apices and periapical periodontitis were enrolled and divided into two groups in the present pilot study. In the PRF group (fourteen teeth in thirteen patients), nonsurgical endodontic treatment was performed using PRF as an apical matrix, after which the apical plug of the MTA was created. For the non-PRF group (fourteen teeth in fourteen patients), nonsurgical endodontic therapy was performed using only the MTA for an apical plug with no further periapical intervention. Clinical findings and periapical digital radiographs were used for evaluating the healing progress after periodic follow-ups of 1, 3, 6, and 9 months. The horizontal dimension of the periapical lesion was gauged, and the changes in the dimensions were recorded each time. The Friedman test, Dunn-Bonferroni post hoc correction, and Mann-Whitney U test were used for statistical analysis, with P < 0.05 serving as the threshold for determining statistical significance. Results: All patients in both groups in the present pilot study had no clinical symptoms after 1 month, with a significant reduction in the periapical lesion after periodic appointments. The lesion width of the PRF group was significantly smaller than that of the non-PRF group in the sixth and ninth month after treatment. Conclusions: PRF is a promising apical barrier matrix when combined with MTA for the treatment of teeth with open apices and periapical periodontitis. Small number of study subjects and the short time of follow-up period limit the generalizability of these results. Trial Registration: TCTR, TCTR20221109006. Registered 09 November 2022 - Retrospectively registered, https://www.thaiclinicaltrials.org/show/TCTR20221109006 . (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | Department of Science and Technology in Ho Chi Minh City Department of Science and Technology in Ho Chi Minh City |
| فهرسة مساهمة: | Keywords: Apical barrier; MTA; Open apex; PRF; Periapical lesion |
| المشرفين على المادة: | 0 (Aluminum Compounds) 0 (Silicates) 0 (mineral trioxide aggregate) 0 (Calcium Compounds) 0 (Drug Combinations) 0 (Oxides) |
| تواريخ الأحداث: | Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240528 |
| رمز التحديث: | 20240528 |
| مُعرف محوري في PubMed: | PMC11128118 |
| DOI: | 10.1186/s12967-024-05318-0 |
| PMID: | 38796431 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1479-5876 |
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| DOI: | 10.1186/s12967-024-05318-0 |