دورية أكاديمية
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Species Difference? Bovine, Trout, and Human Plasma Protein Binding of Per- and Polyfluoroalkyl Substances.

التفاصيل البيبلوغرافية
العنوان: Species Difference? Bovine, Trout, and Human Plasma Protein Binding of Per- and Polyfluoroalkyl Substances.
المؤلفون: Qin W; Department of Cell Toxicology, UFZ─Helmholtz Centre for Environmental Research, 04318 Leipzig, Germany.; Environmental Toxicology, Department of Geosciences, Eberhard Karls University Tübingen, Schnarrenbergstr. 94-96, DE-72076 Tübingen, Germany., Escher BI; Department of Cell Toxicology, UFZ─Helmholtz Centre for Environmental Research, 04318 Leipzig, Germany.; Environmental Toxicology, Department of Geosciences, Eberhard Karls University Tübingen, Schnarrenbergstr. 94-96, DE-72076 Tübingen, Germany., Huchthausen J; Department of Cell Toxicology, UFZ─Helmholtz Centre for Environmental Research, 04318 Leipzig, Germany.; Environmental Toxicology, Department of Geosciences, Eberhard Karls University Tübingen, Schnarrenbergstr. 94-96, DE-72076 Tübingen, Germany., Fu Q; Department of Environmental Analytical Chemistry, UFZ─Helmholtz Centre for Environmental Research, 04318 Leipzig, Germany., Henneberger L; Department of Cell Toxicology, UFZ─Helmholtz Centre for Environmental Research, 04318 Leipzig, Germany.
المصدر: Environmental science & technology [Environ Sci Technol] 2024 Jun 11; Vol. 58 (23), pp. 9954-9966. Date of Electronic Publication: 2024 May 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE
أسماء مطبوعة: Publication: Washington DC : American Chemical Society
Original Publication: Easton, Pa. : American Chemical Society, c1967-
مواضيع طبية MeSH: Blood Proteins*/metabolism , Fluorocarbons*/metabolism , Fluorocarbons*/blood , Protein Binding* , Trout*/metabolism, Animals ; Cattle ; Humans ; Serum Albumin, Bovine/metabolism ; Serum Albumin, Bovine/chemistry ; Species Specificity
مستخلص: Per- and polyfluoroalkyl substances (PFAS) strongly bind to proteins and lipids in blood, which govern their accumulation and distribution in organisms. Understanding the plasma binding mechanism and species differences will facilitate the quantitative in vitro -to- in vivo extrapolation and improve risk assessment of PFAS. We studied the binding mechanism of 16 PFAS to bovine serum albumin (BSA), trout, and human plasma using solid-phase microextraction. Binding of anionic PFAS to BSA and human plasma was found to be highly concentration-dependent, while trout plasma binding was linear for the majority of the tested PFAS. At a molar ratio of PFAS to protein ν < 0.1 mol PFAS /mol protein , the specific protein binding of anionic PFAS dominated their human plasma binding. This would be the scenario for physiological conditions (ν < 0.01), whereas in in vitro assays, PFAS are often dosed in excess (ν > 1) and nonspecific binding becomes dominant. BSA was shown to serve as a good surrogate for human plasma. As trout plasma contains more lipids, the nonspecific binding to lipids affected the affinities of PFAS for trout plasma. Mass balance models that are parameterized with the protein-water and lipid-water partitioning constants (chemical characteristics), as well as the protein and lipid contents of the plasma (species characteristics), were successfully used to predict the binding to human and trout plasma.
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فهرسة مساهمة: Keywords: PFAS; plasma binding mechanism; proteins and lipids; solid-phase microextraction; specific and nonspecific protein binding
المشرفين على المادة: 0 (Blood Proteins)
0 (Fluorocarbons)
27432CM55Q (Serum Albumin, Bovine)
تواريخ الأحداث: Date Created: 20240528 Date Completed: 20240611 Latest Revision: 20240910
رمز التحديث: 20240911
مُعرف محوري في PubMed: PMC11171458
DOI: 10.1021/acs.est.3c10824
PMID: 38804966
قاعدة البيانات: MEDLINE
الوصف
تدمد:1520-5851
DOI:10.1021/acs.est.3c10824