دورية أكاديمية
Acute hypernatremia increases functional connectivity of NaCl sensing regions in the human brain: An fMRI pilot study.
| العنوان: | Acute hypernatremia increases functional connectivity of NaCl sensing regions in the human brain: An fMRI pilot study. |
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| المؤلفون: | Stock JM; University of Delaware, Newark, DE, United States of America., Romberger NT; University of Delaware, Newark, DE, United States of America., McMillan RK; University of Delaware, Newark, DE, United States of America., Chung JW; University of Minnesota, Minneapolis, MN, United States of America., Wenner MM; University of Delaware, Newark, DE, United States of America., Stocker SD; University of Pittsburgh, Pittsburgh, PA, United States of America., Farquhar WB; University of Delaware, Newark, DE, United States of America., Burciu RG; University of Delaware, Newark, DE, United States of America. Electronic address: rgburciu@udel.edu. |
| المصدر: | Autonomic neuroscience : basic & clinical [Auton Neurosci] 2024 Aug; Vol. 254, pp. 103182. Date of Electronic Publication: 2024 May 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100909359 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7484 (Electronic) Linking ISSN: 15660702 NLM ISO Abbreviation: Auton Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Amsterdam ; New York] : Elsevier, c2000- |
| مواضيع طبية MeSH: | Hypernatremia*/physiopathology , Magnetic Resonance Imaging*, Humans ; Pilot Projects ; Male ; Female ; Adult ; Young Adult ; Saline Solution, Hypertonic/pharmacology ; Brain/diagnostic imaging ; Brain/physiopathology ; Neural Pathways/physiopathology ; Neural Pathways/diagnostic imaging ; Subfornical Organ/drug effects ; Subfornical Organ/physiology ; Organum Vasculosum/physiology ; Organum Vasculosum/physiopathology ; Thirst/physiology ; Sodium Chloride/administration & dosage ; Sodium Chloride/pharmacology |
| مستخلص: | Rodent studies demonstrated specialized sodium chloride (NaCl) sensing neurons in the circumventricular organs, which mediate changes in sympathetic nerve activity, arginine vasopressin, thirst, and blood pressure. However, the neural pathways involved in NaCl sensing in the human brain are incompletely understood. The purpose of this pilot study was to determine if acute hypernatremia alters the functional connectivity of NaCl-sensing regions of the brain in healthy young adults. Resting-state fMRI scans were acquired in 13 participants at baseline and during a 30 min hypertonic saline infusion (HSI). We used a seed-based approach to analyze the data, focusing on the subfornical organ (SFO) and the organum vasculosum of the lamina terminalis (OVLT) as regions of interest (ROIs). Blood chemistry and perceived thirst were assessed pre- and post-infusion. As expected, serum sodium increased from pre- to post-infusion in the HSI group. The primary finding of this pilot study was that the functional connectivity between the SFO and a cluster within the OVLT increased from baseline to the late-phase of the HSI. Bidirectional connectivity changes were found with cortical regions, with some regions showing increased connectivity with sodium-sensing regions while others showed decreased connectivity. Furthermore, the functional connectivity between the SFO and the posterior cingulate cortex (a control ROI) did not change from baseline to the late-phase of the HSI. This finding indicates a distinct response within the NaCl sensing network in the human brain specifically related to acute hypernatremia that will need to be replicated in large-scale studies. Competing Interests: Declaration of competing interest None. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Functional MRI; Hypernatremia; NaCl sensing; Osmoreceptors |
| المشرفين على المادة: | 0 (Saline Solution, Hypertonic) 451W47IQ8X (Sodium Chloride) |
| تواريخ الأحداث: | Date Created: 20240528 Date Completed: 20240722 Latest Revision: 20240722 |
| رمز التحديث: | 20240723 |
| DOI: | 10.1016/j.autneu.2024.103182 |
| PMID: | 38805791 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-7484 |
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| DOI: | 10.1016/j.autneu.2024.103182 |