دورية أكاديمية
Sex- and cycle-dependent changes in spine density and size in hippocampal CA2 neurons.
| العنوان: | Sex- and cycle-dependent changes in spine density and size in hippocampal CA2 neurons. |
|---|---|
| المؤلفون: | Jabra S; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., Rietsche M; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., Muellerleile J; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., O'Leary A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, University Hospital, Heinrich-Hoffmann-Straße 10, 60528, Frankfurt am Main, Germany., Slattery DA; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, University Hospital, Heinrich-Hoffmann-Straße 10, 60528, Frankfurt am Main, Germany., Deller T; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., Fellenz M; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. m.fellenz@em.uni-frankfurt.de. |
| المصدر: | Scientific reports [Sci Rep] 2024 May 28; Vol. 14 (1), pp. 12252. Date of Electronic Publication: 2024 May 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Dendritic Spines*/metabolism , Dendritic Spines*/physiology , Estrous Cycle*/physiology , CA2 Region, Hippocampal*/physiology , CA2 Region, Hippocampal*/metabolism, Animals ; Male ; Female ; Mice ; Sex Characteristics ; Neurons/metabolism |
| مستخلص: | Sex hormones affect structural and functional plasticity in the rodent hippocampus. However, hormone levels not only differ between males and females, but also fluctuate across the female estrous cycle. While sex- and cycle-dependent differences in dendritic spine density and morphology have been found in the rodent CA1 region, but not in the CA3 or the dentate gyrus, comparable structural data on CA2, i.e. the hippocampal region involved in social recognition memory, is so far lacking. In this study, we, therefore, used wildtype male and female mice in diestrus or proestrus to analyze spines on dendritic segments from identified CA2 neurons. In basal stratum oriens, we found no differences in spine density, but a significant shift towards larger spine head areas in male mice compared to females. Conversely, in apical stratum radiatum diestrus females had a significantly higher spine density, and females in either cycle stage had a significant shift towards larger spine head areas as compared to males, with diestrus females showing the larger shift. Our results provide further evidence for the sexual dimorphism of hippocampal area CA2, and underscore the importance of considering not only the sex, but also the stage of the estrous cycle when interpreting morphological data. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: CA1; CA2; CA3; Estrogen; Estrous cycle; Hippocampus; Spine; Structural plasticity |
| تواريخ الأحداث: | Date Created: 20240528 Date Completed: 20240528 Latest Revision: 20240531 |
| رمز التحديث: | 20240531 |
| مُعرف محوري في PubMed: | PMC11133407 |
| DOI: | 10.1038/s41598-024-62951-x |
| PMID: | 38806649 |
| قاعدة البيانات: | MEDLINE |
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