دورية أكاديمية
DXA-derived lumbar bone strain index corrected for kyphosis is associated with vertebral fractures and trabecular bone score in acromegaly.
| العنوان: | DXA-derived lumbar bone strain index corrected for kyphosis is associated with vertebral fractures and trabecular bone score in acromegaly. |
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| المؤلفون: | Jaafar S; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; Endocrinology, Diabetology and Andrology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Cristofolini G; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; Endocrinology, Diabetology and Andrology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Morenghi E; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; Biostatistics Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Rinaudo L; Tecnologie Avanzate S.r.l., Turin, Italy., Birtolo MF; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; Endocrinology, Diabetology and Andrology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Sala E; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Endocrinology Unit, Milan, Italy., Ferrante E; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Endocrinology Unit, Milan, Italy., Mungari R; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Endocrinology Unit, Milan, Italy., Lavezzi E; Endocrinology, Diabetology and Andrology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Leonardi L; Department of Radiology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Ragucci P; Department of Radiology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Ulivieri FM; Bone Metabolic Unit, Casa di Cura la Madonnina Milan, Milan, Italy., Balzarini L; Department of Radiology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Mantovani G; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Endocrinology Unit, Milan, Italy.; University of Milan, Department of Clinical Sciences and Community Health, Milan, Italy., Lania AG; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. andrea.lania@hunimed.eu.; Endocrinology, Diabetology and Andrology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy. andrea.lania@hunimed.eu., Mazziotti G; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; Endocrinology, Diabetology and Andrology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy. |
| المصدر: | Endocrine [Endocrine] 2024 Sep; Vol. 85 (3), pp. 1319-1326. Date of Electronic Publication: 2024 May 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9434444 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0100 (Electronic) Linking ISSN: 1355008X NLM ISO Abbreviation: Endocrine Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Feb. 1996- : Totowa, NJ : Humana Press Original Publication: Houndsmills, Basingstoke, Hants, UK : Macmillan Press, c1994- |
| مواضيع طبية MeSH: | Acromegaly*/complications , Acromegaly*/physiopathology , Acromegaly*/diagnostic imaging , Spinal Fractures*/diagnostic imaging , Spinal Fractures*/etiology , Lumbar Vertebrae*/diagnostic imaging , Absorptiometry, Photon* , Cancellous Bone*/diagnostic imaging , Kyphosis*/diagnostic imaging , Bone Density*, Humans ; Male ; Female ; Middle Aged ; Aged ; Adult |
| مستخلص: | Purpose: The bone strain index (BSI) is a marker of bone deformation based on a finite element analysis inferred from dual X-ray absorptiometry (DXA) scans, that has been proposed as a predictor of fractures in osteoporosis (i.e., higher BSI indicates a lower bone's resistance to loads with consequent higher risk of fractures). We aimed to investigate the association between lumbar BSI and vertebral fractures (VFs) in acromegaly. Methods: Twenty-three patients with acromegaly (13 males, mean age 58 years; three with active disease) were evaluated for morphometric VFs, trabecular bone score (TBS), bone mineral density (BMD) and BSI at lumbar spine, the latter being corrected for the kyphosis as measured by low-dose X-ray imaging system (EOS®-2D/3D). Results: Lumbar BSI was significantly higher in patients with VFs as compared to those without fractures (2.90 ± 1.46 vs. 1.78 ± 0.33, p = 0.041). BSI was inversely associated with TBS (rho -0.44; p = 0.034), without significant associations with BMD (p = 0.151), age (p = 0.500), BMI (p = 0.957), serum IGF-I (p = 0.889), duration of active disease (p = 0.434) and sex (p = 0.563). Conclusions: Lumbar BSI corrected for kyphosis could be proposed as integrated parameter of spine arthropathy and osteopathy in acromegaly helping the clinicians in identifying patients with skeletal fragility possibly predisposed to VFs. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Acromegaly; Arthropathy; Bone strain index; Spine imbalance; Trabecular bone score; Vertebral fractures |
| تواريخ الأحداث: | Date Created: 20240529 Date Completed: 20240810 Latest Revision: 20240810 |
| رمز التحديث: | 20240812 |
| DOI: | 10.1007/s12020-024-03863-8 |
| PMID: | 38809345 |
| قاعدة البيانات: | MEDLINE |
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