دورية أكاديمية
Coronary Atherosclerotic Plaque Activity and Risk of Myocardial Infarction.
| العنوان: | Coronary Atherosclerotic Plaque Activity and Risk of Myocardial Infarction. |
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| المؤلفون: | Wang KL; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; General Clinical Research Center, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address: k.l.wang@ed.ac.uk., Balmforth C; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom., Meah MN; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom., Daghem M; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom., Moss AJ; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom., Tzolos E; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom., Kwiecinski J; Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland., Molek-Dziadosz P; Department of Coronary Artery Disease and Heart Failure, John Paul II Hospital, Kraków, Poland., Craig N; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom., Bularga A; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom., Adamson PD; Christchurch Heart Institute, University of Otago, Christchurch, New Zealand., Dawson DK; Aberdeen Cardiovascular and Diabetes Centre, University of Aberdeen, Aberdeen, United Kingdom., Arumugam P; Manchester University National Health Service (NHS) Foundation Trust, Manchester, United Kingdom., Sabharwal NK; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Greenwood JP; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom; Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom; The Baker Heart and Diabetes Institute, Monash University, and University of Melbourne, Melbourne, Victoria, Australia., Townend JN; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom., Calvert PA; Royal Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Rudd JHF; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Verjans JW; Australian Institute for Machine Learning, University of Adelaide, Adelaide, South Australia, Australia; Royal Adelaide Hospital, Adelaide, South Australia, Australia., Berman DS; Cedars-Sinai Medical Center, Los Angeles, California, USA., Slomka PJ; Cedars-Sinai Medical Center, Los Angeles, California, USA., Dey D; Cedars-Sinai Medical Center, Los Angeles, California, USA., Mills NL; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom., van Beek EJR; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom., Williams MC; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom., Dweck MR; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom., Newby DE; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom. |
| مؤلفون مشاركون: | PRE(18)FFIR Study Investigators |
| المصدر: | Journal of the American College of Cardiology [J Am Coll Cardiol] 2024 Jun 04; Vol. 83 (22), pp. 2135-2144. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print Cited Medium: Internet ISSN: 1558-3597 (Electronic) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [New York, N.Y.] : Elsevier Biomedical, [c1983- |
| مواضيع طبية MeSH: | Plaque, Atherosclerotic*/diagnostic imaging , Plaque, Atherosclerotic*/complications , Myocardial Infarction*/epidemiology , Myocardial Infarction*/etiology , Coronary Artery Disease*/epidemiology , Coronary Artery Disease*/diagnostic imaging, Humans ; Male ; Female ; Middle Aged ; Aged ; Positron-Emission Tomography ; Coronary Vessels/diagnostic imaging ; Risk Factors |
| مستخلص: | Background: Total coronary atherosclerotic plaque activity across the entire coronary arterial tree is associated with patient-level clinical outcomes. Objectives: We aimed to investigate whether vessel-level coronary atherosclerotic plaque activity is associated with vessel-level myocardial infarction. Methods: In this secondary analysis of an international multicenter study of patients with recent myocardial infarction and multivessel coronary artery disease, we assessed vessel-level coronary atherosclerotic plaque activity using coronary 18 F-sodium fluoride positron emission tomography to identify vessel-level myocardial infarction. Results: Increased 18 F-sodium fluoride uptake was found in 679 of 2,094 coronary arteries and 414 of 691 patients. Myocardial infarction occurred in 24 (4%) vessels with increased coronary atherosclerotic plaque activity and in 25 (2%) vessels without increased coronary atherosclerotic plaque activity (HR: 2.08; 95% CI: 1.16-3.72; P = 0.013). This association was not demonstrable in those treated with coronary revascularization (HR: 1.02; 95% CI: 0.47-2.25) but was notable in untreated vessels (HR: 3.86; 95% CI: 1.63-9.10; P Conclusions: In patients with recent myocardial infarction and multivessel coronary artery disease, coronary atherosclerotic plaque activity prognosticates individual coronary arteries and patients at risk for myocardial infarction. Competing Interests: Funding Support and Author Disclosures The PRE(18)FFIR study was funded by the Wellcome Trust (WT103782AIA). The funder played no roles in the design and conduct of the study, collection, management, analysis, and interpretation of the data, preparation, review, or approval of the manuscript, and any decisions to submit the manuscript for publication. The University of Edinburgh and the National Health Service Lothian Health Board were cosponsors. Dr Rudd is part-supported by the National Institute for Health and Care Research Cambridge Biomedical Research Centre, the British Heart Foundation, the Higher Education Funding Council for England, the Engineering and Physical Sciences Research Council, and the Wellcome Trust. Dr Piotr is supported by the National Heart, Lung, and Blood Institute at the National Institutes of Health (R35HL161195). Dr Mills is supported by the British Heart Foundation (CH/F/21/90010, RE/18/5/34216, and RG/20/10/34966). Dr van Beek is supported by the Scottish Imaging Network. Dr Williams is supported by the British Heart Foundation (FS/ICRF/20/26002). Dr Dweck is supported by the British Heart Foundation (FS/SCRF/21/32010). Dr Newby is supported by the British Heart Foundation (CH/09/002, RE/18/5/34216, and RG/F/22/110093). Dr Moss is a current employee of AstraZeneca. Dr Williams has given talks for Canon Medical Systems, Novartis, and Siemens Healthineers. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. (Copyright © 2024 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; R35 HL161195 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: coronary atherosclerotic plaque activity; myocardial infarction; positron emission tomography |
| تواريخ الأحداث: | Date Created: 20240529 Date Completed: 20240529 Latest Revision: 20240719 |
| رمز التحديث: | 20240719 |
| مُعرف محوري في PubMed: | PMC11254330 |
| DOI: | 10.1016/j.jacc.2024.03.419 |
| PMID: | 38811091 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1558-3597 |
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| DOI: | 10.1016/j.jacc.2024.03.419 |