Diurnal rhythm of urinary aquaporin-2 in children with primary monosymptomatic nocturnal enuresis.

التفاصيل البيبلوغرافية
العنوان:	Diurnal rhythm of urinary aquaporin-2 in children with primary monosymptomatic nocturnal enuresis.
المؤلفون:	Abdelhamid N; Departments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt., Almawla MAA; Departments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt., Wahby AA; Department of Clinical Pathology, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt., Ismail M; Departments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt., Elmikaty HA; Departments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt., Hamed HM; Departments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt., Ashmawy I; Department of Clinical Pathology, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt., Abdelraoaf BM; Departments of Pediatrics, Ainshams University, Cairo, Egypt., Abdelhamid EM; Departments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt., Salam HM; Departments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.
المصدر:	Turkish journal of medical sciences [Turk J Med Sci] 2023 Nov 27; Vol. 54 (1), pp. 194-203. Date of Electronic Publication: 2023 Nov 27 (Print Publication: 2024).
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Scientific and Technical Research Council of Turkey Country of Publication: Turkey NLM ID: 9441758 Publication Model: eCollection Cited Medium: Internet ISSN: 1303-6165 (Electronic) Linking ISSN: 13000144 NLM ISO Abbreviation: Turk J Med Sci Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Ankara : Scientific and Technical Research Council of Turkey, [1994-
مواضيع طبية MeSH:	Nocturnal Enuresis/urine , Nocturnal Enuresis/blood , Aquaporin 2/urine , Circadian Rhythm/physiology , Biomarkers/urine , Biomarkers/blood, Humans ; Child ; Male ; Female ; Osmolar Concentration ; Case-Control Studies ; Arginine Vasopressin/blood ; Arginine Vasopressin/urine ; Adolescent
مستخلص:	Background/aim: Nocturnal enuresis can be frustrating for children and their families as the child ages. Our aim is to evaluate urine aquaporin 2 (AQP-2) as a noninvasive biomarker of water balance in children with primary monosymptomatic nocturnal enuresis (PMNE). Material and Methods: The study included 90 children; sixty-eight children suffering from PMNE aged (9.57 ± 2.16) years and 22 healthy children with good toilet control, matched sex and age. All enuretic children were subjected to complete history taking, clinical evaluation, and bed wetting diary. Serum arginine vasopressin (AVP) and urine AQP-2 were tested in the morning (at 9-11 am) and evening (at 9-11 pm). Blood urea, creatinine, Na, glucose, urine osmolality, Ca/Cr, Alb/Cr and specific gravity were tested simultaneously. Results: Serum AVP, urine AQP-2, and urine osmolality were statistically lower in patients than controls. Patients had a significantly lower level of night serum AVP concentrations, urine AQP-2, and urine osmolality than the corresponding morning level. Urine AQP-2 was significantly correlated with urine osmolality (p < 0.05). AQP-2 had a sensitivity of 90% and a specificity of 70%. However, no statistically significant correlation was found between serum AVP and urine AQP-2. Conclusion: Primary monosymptomatic nocturnal enuresis in children could be associated with reduction of urine excretion of AQP-2 at night. Urine AQP-2 is significantly correlated with urine osmolality. Therefore, it may be a noninvasive biomarker of hydration status in children with PMNE, with good sensitivity and specificity. Competing Interests: Conflict of interest: No potential conflict of interest was reported by the author(s). (© TÜBİTAK.)
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فهرسة مساهمة:	Keywords: Aquaporin 2; nocturnal enuresis; vasopressin
المشرفين على المادة:	0 (Aquaporin 2) 0 (Biomarkers) 113-79-1 (Arginine Vasopressin) 0 (AQP2 protein, human)
تواريخ الأحداث:	Date Created: 20240530 Date Completed: 20240530 Latest Revision: 20240606
رمز التحديث:	20240606
مُعرف محوري في PubMed:	PMC11031170
DOI:	10.55730/1300-0144.5780
PMID:	38812639
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1303-6165
DOI:	10.55730/1300-0144.5780