Hypothyroidism Presenting Atypically as an Isolated Pericardial and Pleural Effusion: A Case Report.

التفاصيل البيبلوغرافية
العنوان: Hypothyroidism Presenting Atypically as an Isolated Pericardial and Pleural Effusion: A Case Report.
المؤلفون: Shaja S; Family Medicine, JenCare Senior Medical Center, Glenwood, USA., Khaleeluddin MA; Family Medicine, JenCare Senior Medical Center, Glenwood, USA.
المصدر: Cureus [Cureus] 2024 Apr 29; Vol. 16 (4), pp. e59255. Date of Electronic Publication: 2024 Apr 29 (Print Publication: 2024).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Hypothyroidism is an endocrine disorder characterized by low thyroid hormone levels, which commonly presents as fatigue, cold intolerance, constipation, poor memory and/or concentration, and weight gain. Common signs of hypothyroidism include bradycardia, electrocardiograph changes, a lower basal temperature, a slower relaxation phase of deep tendon reflexes, and swelling of the extremities. Hypothyroidism is diagnosed with labs showing high thyroid-stimulating hormone levels and low free thyroxine. Hypothyroidism may present as a pericardial or pleural effusion, with the incidence of each being unknown. The paucity of information regarding the incidence of pericardial and pleural effusions in hypothyroidism may be due to effusions being an atypical complication of a common endocrine disorder. Hypothyroidism, including in cases of pericardial or pleural effusions, is typically treated with thyroid hormone replacement therapy, usually in the form of levothyroxine. Hemodynamic compromise may necessitate pericardiocentesis or pleurocentesis. In this case report, we present an atypical presentation of hypothyroidism that is characterized by an isolated pericardial and pleural effusion in a patient with post-thyroidectomy hypothyroidism who was non-adherent to levothyroxine. We discuss the pathophysiology of pleural and pericardial effusions in thyroid disease, which is thought to involve increased capillary permeability and changes in oncotic pressure related to albumin. We also review treatment strategies regarding pericardial and pleural effusions in hypothyroidism.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2024, Shaja et al.)
References: Am Fam Physician. 2021 May 15;103(10):605-613. (PMID: 33983002)
JAMA. 1974 Nov 11;230(6):884-5. (PMID: 4479390)
Heart. 2019 Jul;105(13):1027-1033. (PMID: 30948517)
Chest. 1990 Nov;98(5):1130-2. (PMID: 2135384)
J Endocr Soc. 2020 Aug 27;5(1):bvaa125. (PMID: 33354637)
Am Fam Physician. 2000 Dec 1;62(11):2485-90. (PMID: 11130234)
Cureus. 2023 Dec 13;15(12):e50429. (PMID: 38222246)
Endocr Pract. 2012 Nov-Dec;18(6):988-1028. (PMID: 23246686)
J Cardiovasc Dis Res. 2013 Dec;4(4):248-50. (PMID: 24653591)
N Engl J Med. 2017 Jun 29;376(26):2534-2544. (PMID: 28402245)
Front Endocrinol (Lausanne). 2023 Feb 06;14:1130661. (PMID: 36814580)
N Engl J Med. 1979 Aug 30;301(9):460-5. (PMID: 460364)
Lancet. 2017 Sep 23;390(10101):1550-1562. (PMID: 28336049)
Thyroid. 2014 Dec;24(12):1670-751. (PMID: 25266247)
Methodist Debakey Cardiovasc J. 2017 Apr-Jun;13(2):55-59. (PMID: 28740582)
BMJ Open. 2019 Jun 21;9(6):e023854. (PMID: 31229996)
Am J Med. 2012 Sep;125(9):882-7.e1. (PMID: 22748400)
Am Fam Physician. 2014 Jul 15;90(2):99-104. (PMID: 25077579)
JAMA. 2019 Jul 09;322(2):153-160. (PMID: 31287527)
Pharmacotherapy. 2008 Apr;28(4):437-43. (PMID: 18363527)
فهرسة مساهمة: Keywords: atrial fibrillation; bradycardia; hypothyroidism; levothyroxine; pericardial effusion; pleural effusion; secondary hypothyroidism; thyroid-stimulating hormone; thyrotropin
تواريخ الأحداث: Date Created: 20240530 Latest Revision: 20240531
رمز التحديث: 20240531
مُعرف محوري في PubMed: PMC11134305
DOI: 10.7759/cureus.59255
PMID: 38813286
قاعدة البيانات: MEDLINE