دورية أكاديمية
Preliminary evidence of localizing CD8+ T-cell responses in COVID-19 patients with PET imaging.
| العنوان: | Preliminary evidence of localizing CD8+ T-cell responses in COVID-19 patients with PET imaging. |
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| المؤلفون: | Koenen HJPM; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Kouijzer IJE; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands., de Groot M; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands., Peters S; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands., Lobeek D; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands., van Genugten EAJ; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands., Diavatopoulos DA; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands., van Oosten N; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands., Gianotten S; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands., Prokop MM; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands., van de Veerdonk FL; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands., Aarntzen EHJG; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands. |
| المصدر: | Frontiers in medicine [Front Med (Lausanne)] 2024 May 15; Vol. 11, pp. 1414415. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2014]- |
| مستخلص: | Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. |
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| فهرسة مساهمة: | Keywords: CD8+ T-cells; PET imaging; SARS-CoV2; mucosal immunity; trafficking Local Abstract: [Publisher, Dutch; Flemish] The upper respiratory tract (URT) is the entry site for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), from where it further disseminates. Early and effective adaptive immune responses are crucial to restrict viral replication and limit symptom development and transmission. Current vaccines increasingly incorporate strategies to boost mucosal immunity in the respiratory tract. Positron emission tomography (PET) is a non-invasive technology that measures cellular responses at a whole-body level. In this case series, we explored the feasibility of [ 89 Zr]Zr-crefmirlimab berdoxam PET to assess CD8+ T-cell localization during active COVID-19. Our results suggest that CD8+ T-cell distributions assessed by PET imaging reflect their differentiation and functional state in blood. Therefore, PET imaging may represent a novel tool to visualize and quantify cellular immune responses during infections at a whole-body level. |
| تواريخ الأحداث: | Date Created: 20240530 Latest Revision: 20240531 |
| رمز التحديث: | 20240531 |
| مُعرف محوري في PubMed: | PMC11133695 |
| DOI: | 10.3389/fmed.2024.1414415 |
| PMID: | 38813383 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-858X |
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| DOI: | 10.3389/fmed.2024.1414415 |