دورية أكاديمية
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Glucose appetition in C57BL/6J mice: Influence of nonnutritive sweetener experience, food deprivation state and sex differences.

التفاصيل البيبلوغرافية
العنوان: Glucose appetition in C57BL/6J mice: Influence of nonnutritive sweetener experience, food deprivation state and sex differences.
المؤلفون: Sclafani A; Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA. Electronic address: anthonys@brooklyn.cuny.edu., Ackroff K; Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA.
المصدر: Physiology & behavior [Physiol Behav] 2024 Sep 01; Vol. 283, pp. 114596. Date of Electronic Publication: 2024 May 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE
أسماء مطبوعة: Publication: New York NY : Elsevier Science
Original Publication: Oxford, Eng., Long Island City, Pergamon Press.
مواضيع طبية MeSH: Mice, Inbred C57BL* , Glucose*/pharmacology , Food Deprivation*/physiology , Sweetening Agents*/pharmacology , Sweetening Agents*/administration & dosage , Sex Characteristics* , Sucrose*/pharmacology , Sucrose*/administration & dosage , Sucrose*/analogs & derivatives, Animals ; Male ; Female ; Mice ; Food Preferences/drug effects ; Food Preferences/physiology ; Saccharin/pharmacology ; Saccharin/administration & dosage ; Dose-Response Relationship, Drug
مستخلص: In addition to its sweet taste, glucose has potent and rapid postoral actions (appetition) that enhance its reward value. This has been demonstrated by the experience-induced preference for glucose over initially preferred nonnutritive sweetener solutions in 24-h choice tests. However, some sweetener solutions (e.g., 0.8% sucralose) have inhibitory postoral actions that may exaggerate glucose appetition whereas others (e.g., 0.1% sucralose + 0.1% saccharin, S+S) do not. Experiment 1 revealed that food-restricted (FR) male C57BL/6J mice displayed similar rapid glucose appetition effects (stimulation of glucose licking within minutes) and conditioned flavor preferences following 1-h experience with flavored 0.8% sucralose or 0.1% S+S and 8% glucose solutions. Thus, the inhibitory effects of 0.8% sucralose observed in 24-h tests were not apparent in 1-h tests. Experiment 2 evaluated the effects of food deprivation state and sweetener concentration on glucose appetition in female mice. Unlike FR mice tested with 0.1% S+S and 8% glucose, ad libitum (AL) fed mice displayed no stimulation of 8% glucose licking in the 1-h tests. A second ad libitum group (AL) tested with 0.2% S+S and 16% glucose solutions displayed stimulation of 16% glucose licking by the third 1-h test. Both AL groups, like the FR group, developed a preference for the glucose-paired flavor over the S+S paired flavor. Thus, food restriction promotes increased glucose licking but is not required for a conditioned preference. The FR male mice (Exp. 1) and FR female mice (Exp. 2) showed similar appetition responses (licking stimulation and flavor preference) to 8% glucose.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
التعليقات: Update of: bioRxiv. 2024 Feb 28:2024.02.27.582331. doi: 10.1101/2024.02.27.582331. (PMID: 38464099)
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معلومات مُعتمدة: R01 DK031135 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Conditioned flavor preference; Saccharin; Stimulated drinking; Sucralose
المشرفين على المادة: IY9XDZ35W2 (Glucose)
0 (Sweetening Agents)
57-50-1 (Sucrose)
FST467XS7D (Saccharin)
96K6UQ3ZD4 (trichlorosucrose)
تواريخ الأحداث: Date Created: 20240530 Date Completed: 20240713 Latest Revision: 20240716
رمز التحديث: 20240716
مُعرف محوري في PubMed: PMC11246822
DOI: 10.1016/j.physbeh.2024.114596
PMID: 38815713
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-507X
DOI:10.1016/j.physbeh.2024.114596