دورية أكاديمية
Glucose appetition in C57BL/6J mice: Influence of nonnutritive sweetener experience, food deprivation state and sex differences.
العنوان: | Glucose appetition in C57BL/6J mice: Influence of nonnutritive sweetener experience, food deprivation state and sex differences. |
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المؤلفون: | Sclafani A; Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA. Electronic address: anthonys@brooklyn.cuny.edu., Ackroff K; Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA. |
المصدر: | Physiology & behavior [Physiol Behav] 2024 Sep 01; Vol. 283, pp. 114596. Date of Electronic Publication: 2024 May 28. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE |
أسماء مطبوعة: | Publication: New York NY : Elsevier Science Original Publication: Oxford, Eng., Long Island City, Pergamon Press. |
مواضيع طبية MeSH: | Mice, Inbred C57BL* , Glucose*/pharmacology , Food Deprivation*/physiology , Sweetening Agents*/pharmacology , Sweetening Agents*/administration & dosage , Sex Characteristics* , Sucrose*/pharmacology , Sucrose*/administration & dosage , Sucrose*/analogs & derivatives, Animals ; Male ; Female ; Mice ; Food Preferences/drug effects ; Food Preferences/physiology ; Saccharin/pharmacology ; Saccharin/administration & dosage ; Dose-Response Relationship, Drug |
مستخلص: | In addition to its sweet taste, glucose has potent and rapid postoral actions (appetition) that enhance its reward value. This has been demonstrated by the experience-induced preference for glucose over initially preferred nonnutritive sweetener solutions in 24-h choice tests. However, some sweetener solutions (e.g., 0.8% sucralose) have inhibitory postoral actions that may exaggerate glucose appetition whereas others (e.g., 0.1% sucralose + 0.1% saccharin, S+S) do not. Experiment 1 revealed that food-restricted (FR) male C57BL/6J mice displayed similar rapid glucose appetition effects (stimulation of glucose licking within minutes) and conditioned flavor preferences following 1-h experience with flavored 0.8% sucralose or 0.1% S+S and 8% glucose solutions. Thus, the inhibitory effects of 0.8% sucralose observed in 24-h tests were not apparent in 1-h tests. Experiment 2 evaluated the effects of food deprivation state and sweetener concentration on glucose appetition in female mice. Unlike FR mice tested with 0.1% S+S and 8% glucose, ad libitum (AL) fed mice displayed no stimulation of 8% glucose licking in the 1-h tests. A second ad libitum group (AL) tested with 0.2% S+S and 16% glucose solutions displayed stimulation of 16% glucose licking by the third 1-h test. Both AL groups, like the FR group, developed a preference for the glucose-paired flavor over the S+S paired flavor. Thus, food restriction promotes increased glucose licking but is not required for a conditioned preference. The FR male mice (Exp. 1) and FR female mice (Exp. 2) showed similar appetition responses (licking stimulation and flavor preference) to 8% glucose. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
التعليقات: | Update of: bioRxiv. 2024 Feb 28:2024.02.27.582331. doi: 10.1101/2024.02.27.582331. (PMID: 38464099) |
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معلومات مُعتمدة: | R01 DK031135 United States DK NIDDK NIH HHS |
فهرسة مساهمة: | Keywords: Conditioned flavor preference; Saccharin; Stimulated drinking; Sucralose |
المشرفين على المادة: | IY9XDZ35W2 (Glucose) 0 (Sweetening Agents) 57-50-1 (Sucrose) FST467XS7D (Saccharin) 96K6UQ3ZD4 (trichlorosucrose) |
تواريخ الأحداث: | Date Created: 20240530 Date Completed: 20240713 Latest Revision: 20240716 |
رمز التحديث: | 20240716 |
مُعرف محوري في PubMed: | PMC11246822 |
DOI: | 10.1016/j.physbeh.2024.114596 |
PMID: | 38815713 |
قاعدة البيانات: | MEDLINE |
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