دورية أكاديمية
أعرض في EDS

Unraveling the NRF2 confusion: Distinguishing nuclear respiratory factor 2 from nuclear erythroid factor 2.

التفاصيل البيبلوغرافية
العنوان: Unraveling the NRF2 confusion: Distinguishing nuclear respiratory factor 2 from nuclear erythroid factor 2.
المؤلفون: George M; Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA., Reddy AP; Nutritional Sciences Department, College Human Sciences, Texas Tech University, Lubbock, TX 79409, USA., Reddy PH; Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Nutritional Sciences Department, College Human Sciences, Texas Tech University, Lubbock, TX 79409, USA; Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA 5. Department of Public Health, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Speech, Language, and Hearing Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: hemachandra.reddy@ttuhsc.edu., Kshirsagar S; Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: sudhir.kshirsagar@ttuhsc.edu.
المصدر: Ageing research reviews [Ageing Res Rev] 2024 Jul; Vol. 98, pp. 102353. Date of Electronic Publication: 2024 May 28.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, UK : Elsevier Science, c2002-
مواضيع طبية MeSH: NF-E2-Related Factor 2*/metabolism, Humans ; Animals ; GA-Binding Protein Transcription Factor/metabolism ; GA-Binding Protein Transcription Factor/genetics ; Oxidative Stress/physiology
مستخلص: In recent years, the acronym NRF2 has garnered significant attention in scientific discourse. However, this attention has occasionally led to confusion due to the existence of two distinct proteins sharing the same acronym: Nuclear Respiratory Factor 2 (NRF2), also known as GA-binding protein transcription factor subunit alpha (GABPA), and Nuclear Factor Erythroid 2-related Factor 2 (NFE2L2 or NRF2). This confusion has been highlighted in various scientific forums, including PubPeer and anonymous reader comments, where the confusion between the two proteins has been expressed. In this article, we aim to elucidate the disparities between these two proteins. Both are transcription factors that play pivotal roles in cellular homeostasis and response to stress, with some overlapping functional aspects. Nuclear Factor Erythroid 2-related Factor 2 (NFE2L2) is a key regulator of the antioxidant response element (ARE) pathway. It functions by binding to antioxidant response elements in the promoters of target genes, thereby orchestrating the expression of various cytoprotective enzymes and proteins involved in detoxification, redox balance, and cellular defense against oxidative stress. Conversely, Nuclear Respiratory Factor 2 (GABPA) is primarily associated with the regulation of mitochondrial biogenesis, in relation to PGC1α, and maintaining cellular energy metabolism. It is important to recognize and differentiate between these two proteins to avoid misconceptions and misinterpretations in scientific literature and discussions. Our laboratories (Arubala P Reddy and P. Hemachandra Reddy) focued on Nuclear Respiratory Factor 2 (NRF2), but not on Nuclear Factor Erythroid 2-related Factor 2 (NFE2L2). We hope that the facts, figures, and discussions presented in this article will clarify the current controversy regarding the sizes, structural features, and functional aspects of these proteins.
Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest
(Copyright © 2024 Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: RF1 AG079264 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: 2GA-binding protein transcription factor subunit alpha; Mitochondria; Nuclear erythroid factor 2; Nuclear factor erythroid 2-related factor; Nuclear respiratory factor; Oxidative stress
المشرفين على المادة: 0 (NF-E2-Related Factor 2)
0 (GA-Binding Protein Transcription Factor)
0 (NFE2L2 protein, human)
تواريخ الأحداث: Date Created: 20240530 Date Completed: 20240610 Latest Revision: 20240701
رمز التحديث: 20240702
مُعرف محوري في PubMed: PMC11176867
DOI: 10.1016/j.arr.2024.102353
PMID: 38815934
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-9649
DOI:10.1016/j.arr.2024.102353