دورية أكاديمية
Exploring the astonishing beneficial effects of round gourd (Praecitrullus fistulosus) and plant lectins towards cancer: A comprehensive review.
| العنوان: | Exploring the astonishing beneficial effects of round gourd (Praecitrullus fistulosus) and plant lectins towards cancer: A comprehensive review. |
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| المؤلفون: | Jabeen I; National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan., Altemimi AB; Food Science Department, College of Agriculture, University of Basrah, Basrah 61004, Iraq; College of Medicine, University of Warith Al-Anbiyaa, Karbala 56001, Iraq., Rabail R; National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan., Kafeel S; National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan., Shahid A; National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan., Inam-Ur-Raheem M; National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan. Electronic address: raheemuaf@uaf.edu.pk., Mousavi Khaneghah A; Faculty of Biotechnologies (BioTech), ITMO University 191002, 9 Lomonosova Street, Saint Petersburg, Russia; Halal Research Center of IRI, Iran Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran. Electronic address: mousavi.amin@gmail.com., Aadil RM; National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan. Electronic address: muhammad.aadil@uaf.edu.pk. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2024 Jun; Vol. 271 (Pt 2), pp. 132629. Date of Electronic Publication: 2024 May 28. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Plant Lectins*/pharmacology , Plant Lectins*/chemistry , Neoplasms*/drug therapy , Neoplasms*/metabolism , Cucurbitaceae*/chemistry, Humans ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Animals ; Apoptosis/drug effects |
| مستخلص: | Praecitrullus fistulosus, commonly known as round gourd or tinda, is a remarkable source of bioactive substances like polyphenols, antioxidants, carotene, magnesium, and vitamin C. It is considered one of the Cucurbitaceae family due to its medicinal features. Plant lectins are carbohydrate-binding proteins that can bind and identify the carbohydrate moieties upon cancerous cells demonstrated some anticancer potentials. Several plant lectins are helpful as cancer biomarkers because they can find cancer cells and contribute to cell death initiation via apoptosis and autophagy, suggesting the possible role of cancer-inhibiting pathways. Therefore, round gourd and lectins might be useful in the controlling of cancer. This study compiled the most recent scientific literature regarding the round gourd and numerous plant lectins, and the clinical trials of lectins exploring their effects on cancer were examined. Research according to the literature, round gourd, and lectins demonstrated pharmacological alterations not only in cancer but in many other disorders as well. Thus, clinical investigations proved the beneficial impacts of round gourd and lectins on cancer due to their antioxidants, anti-inflammatory, and anticarcinogenic properties. Further studies are required to fully comprehend the potential applications of these plant-derived compounds against cancer, as well as to identify the round gourd components and clarify their mode of action. Competing Interests: Declaration of competing interest The authors declare no conflicts of interst. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bioactive components; Biomarkers; Cancer; Plant lectins; Praecitrullus fistulosus; Round gourd |
| المشرفين على المادة: | 0 (Plant Lectins) 0 (Antioxidants) 0 (Plant Extracts) 0 (Antineoplastic Agents, Phytogenic) |
| تواريخ الأحداث: | Date Created: 20240530 Date Completed: 20240619 Latest Revision: 20240620 |
| رمز التحديث: | 20240621 |
| DOI: | 10.1016/j.ijbiomac.2024.132629 |
| PMID: | 38815952 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2024.132629 |