دورية أكاديمية
Lycopene Protects against Atrazine-Induced Kidney STING-Dependent PANoptosis through Stabilizing mtDNA via Interaction with Sam50/PHB1.
| العنوان: | Lycopene Protects against Atrazine-Induced Kidney STING-Dependent PANoptosis through Stabilizing mtDNA via Interaction with Sam50/PHB1. |
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| المؤلفون: | Yi BJ; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China., Wang CC; Department of Obstetrics & Gynaecology; Li Ka Shing Institute of Health Sciences; School of Biomedical Sciences; and The Chinese University of Hong Kong-Sichuan University Joint Laboratory for Reproductive Medicine, The Chinese University of Hong Kong, Hong Kong, China., Li XW; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China., Xu YR; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China., Ma XY; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China., Jian PA; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China., Talukder M; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China.; Department of Physiology and Pharmacology, Faculty of Animal Science and Veterinary Medicine, Patuakhali Science and Technology University, Barishal 8210, Bangladesh., Li XN; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China.; Department of Obstetrics & Gynaecology; Li Ka Shing Institute of Health Sciences; School of Biomedical Sciences; and The Chinese University of Hong Kong-Sichuan University Joint Laboratory for Reproductive Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, P. R. China.; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin 150030, P. R. China., Li JL; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China.; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, P. R. China.; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin 150030, P. R. China. |
| المصدر: | Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Jul 03; Vol. 72 (26), pp. 14956-14966. Date of Electronic Publication: 2024 May 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: | Atrazine*/toxicity , Kidney*/drug effects , Kidney*/metabolism , Membrane Proteins*/genetics , Membrane Proteins*/metabolism , Lycopene*/pharmacology , Lycopene*/administration & dosage , DNA, Mitochondrial*/genetics , DNA, Mitochondrial*/metabolism , Protective Agents*/pharmacology , Protective Agents*/administration & dosage, Animals ; Mice ; Male ; Humans ; Herbicides ; Kidney Diseases/metabolism ; Kidney Diseases/chemically induced ; Kidney Diseases/prevention & control ; Kidney Diseases/genetics ; Kidney Diseases/drug therapy ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism ; Signal Transduction/drug effects |
| مستخلص: | Atrazine (ATR) is a widely used herbicide worldwide that can cause kidney damage in humans and animals by accumulation in water and soil. Lycopene (LYC), a carotenoid with numerous biological activities, plays an important role in kidney protection due to its potent antioxidant and anti-inflammatory effects. The current study sought to investigate the role of interactions between mtDNA and the cGAS-STING signaling pathway in LYC mitigating PANoptosis and inflammation in kidneys induced by ATR exposure. In our research, 350 mice were orally administered LYC (5 mg/kg BW/day) and ATR (50 or 200 mg/kg BW/day) for 21 days. Our results reveal that ATR exposure induces a decrease in mtDNA stability, resulting in the release of mtDNA into the cytoplasm through the mPTP pore and the BAX pore and the mobilization of the cGAS-STING pathway, thereby inducing renal PANoptosis and inflammation. LYC can inhibit the above changes caused by ATR. In conclusion, LYC inhibited ATR exposure-induced histopathological changes, renal PANoptosis, and inflammation by inhibiting the cGAS-STING pathway. Our results demonstrate the positive role of LYC in ATR-induced renal injury and provide a new therapeutic target for treating renal diseases in the clinic. |
| فهرسة مساهمة: | Keywords: PANoptosis; atrazine; cGAS-STING; inflammation; lycopene; mtDNA; renal injury |
| المشرفين على المادة: | QJA9M5H4IM (Atrazine) 0 (Membrane Proteins) SB0N2N0WV6 (Lycopene) 0 (DNA, Mitochondrial) 0 (Protective Agents) 0 (Herbicides) 0 (Sting1 protein, mouse) EC 2.7.7.- (Nucleotidyltransferases) |
| تواريخ الأحداث: | Date Created: 20240531 Date Completed: 20240703 Latest Revision: 20240703 |
| رمز التحديث: | 20240703 |
| DOI: | 10.1021/acs.jafc.4c02820 |
| PMID: | 38820047 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5118 |
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| DOI: | 10.1021/acs.jafc.4c02820 |