التفاصيل البيبلوغرافية
| العنوان: |
Outcomes of childhood TB in countries with a universal BCG vaccination policy. |
| المؤلفون: |
Dias JV; Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Department of Paediatrics, Hospital Beatriz Ângelo, Loures., Varandas L; Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Department of Paediatrics, Hospital Dona Estefânia, Lisbon., Gonçalves L; Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Centro de Estatística e Aplicações da Universidade de Lisboa, Lisbon, z-Stat4life, Lisbon, Portugal., Kagina B; Vaccines for Africa Initiative, School of Public Health, University of Cape Town, Cape Town, Institute of Molecular Medicine & Infectious Diseases, University of Cape Town, South Africa. |
| المصدر: |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2024 Jun 01; Vol. 28 (6), pp. 273-277. |
| نوع المنشور: |
Journal Article; Systematic Review; Meta-Analysis |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: The Union Country of Publication: France NLM ID: 9706389 Publication Model: Print Cited Medium: Internet ISSN: 1815-7920 (Electronic) Linking ISSN: 10273719 NLM ISO Abbreviation: Int J Tuberc Lung Dis Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Paris, France : The Union, c1997- |
| مواضيع طبية MeSH: |
BCG Vaccine*/administration & dosage , Tuberculosis*/epidemiology , Tuberculosis*/prevention & control, Humans ; Infant ; Child ; Child, Preschool ; Adolescent ; Infant, Newborn ; Vaccination/statistics & numerical data ; Health Policy |
| مستخلص: |
BACKGROUNDTB remains an important cause of childhood morbidity and mortality. Underdiagnosis, underreporting and limited data on the outcomes of childhood TB have led to an underestimation of its impact.METHODSThis was a systematic review to characterise childhood TB outcomes. Studies reporting relevant epidemiological data on children between 0 and 14 years of age, with a particular focus on treatment outcomes, from countries with universal bacilli Calmette-Guérin (BCG) vaccination and conducted between 2000 and 2020 were selected. Random effects meta-analysis was performed in R software.RESULTSWe identified 1,806 references and included 35 articles. Among children with TB, the overall proportion of unfavourable outcomes was 19.5% (95% CI 14.4-25.8) and pooled case-fatality ratio was 6.1% (95% CI 4.3-8.4). The proportion of deaths observed among children between 0 and 4 years old was 6.6% (95% CI 4.9-8.7) and 4.6% (95% CI 3.1-6.9) in older children. TB and HIV co-infected children presented a case-fatality ratio of 15.1% (95% CI 7.9-27.0).CONCLUSIONSDespite the efforts made in the last decades, treatment outcomes in childhood TB are still worrisome. Efforts to fill existing gaps and design health policies targeting vulnerable populations, such as children, should be intensified to tackle the global TB burden.. |
| المشرفين على المادة: |
0 (BCG Vaccine) |
| تواريخ الأحداث: |
Date Created: 20240601 Date Completed: 20240601 Latest Revision: 20240603 |
| رمز التحديث: |
20240604 |
| DOI: |
10.5588/ijtld.23.0321 |
| PMID: |
38822485 |
| قاعدة البيانات: |
MEDLINE |
