EuroGuiderm guideline on lichen sclerosus-Treatment of lichen sclerosus.

التفاصيل البيبلوغرافية
العنوان:	EuroGuiderm guideline on lichen sclerosus-Treatment of lichen sclerosus.
المؤلفون:	Kirtschig G; Medbase Health Centre, Frauenfeld, Switzerland., Kinberger M; Division of Evidence-Based Medicine (dEBM), Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Kreuter A; Department of Dermatology, Venereology, and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, Oberhausen, Germany., Simpson R; Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK., Günthert A; Gynäkologisches Tumorzentrum St. Anna, Lucerne, Switzerland., van Hees C; Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands., Becker K; Office for Paediatric Surgery, Bonn, Germany., Ramakers MJ; CenSeRe (Centre for Psychological, Relational, Sexual Health), Voorschoten, The Netherlands., Corazza M; Section of Dermatology and Infectious Diseases, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Müller S; Department of Dermatology, University Hospital Basel, Basel, Switzerland., von Seitzberg S; The Danish Lichen Sclerosus Association, Hørve, Denmark., Boffa MJ; Department of Dermatology, Mater Dei Hospital, Msida, Malta., Stein R; Center for Pediatric, Adolescent and Reconstructive Urology, Medical Faculty Mannheim, University of Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Barbagli G; Centro Chirurgico Toscano, Arezzo, Italy., Chi CC; Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Dauendorffer JN; Department of Dermatology, Centre for Genital and Sexually Transmitted Diseases, University Hospital Saint Louis, Paris, France., Fischer B; The Swiss Lichen Sclerosus Association, Switzerland/Verein Lichen Sclerosus e.V., Dottikon, Switzerland., Gaskins M; Division of Evidence-Based Medicine (dEBM), Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Hiltunen-Back E; Department of Dermatovenereology, Helsinki University Hospital, Helsinki, Finland., Höfinger A; The Swiss Lichen Sclerosus Association, Switzerland/Verein Lichen Sclerosus e.V., Dottikon, Switzerland., Köllmann NH; The Swiss Lichen Sclerosus Association, Switzerland/Verein Lichen Sclerosus e.V., Dottikon, Switzerland., Kühn H; The German Lichen Sclerosus Association, Hamburg, Germany., Larsen HK; Department of Dermatology and Venereology, Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen, Denmark., Lazzeri M; Department of Urology, IRCCS Humanitas Research Hospital, Rozzano, MI, Italy., Mendling W; German Center for Infections in Gynecology and Obstetrics, Helios University Hospital Wuppertal-University Witten/Herdecke, Wuppertal, Germany., Nikkels AF; Department of Dermatology, University Medical Center of Liège, Liège, Belgium., Promm M; Department of Paediatric Urology and Clinic St. Hedwig, University Medical Centre of Regensburg, Regensburg, Germany., Rall KK; Department of Women's Health, Women's University Hospital Tuebingen, Tuebingen, Germany., Regauer S; Diagnostic and Research Institute of Pathology, Medical University Graz, Graz, Austria., Sárdy M; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary., Sepp N; Department of Dermatology and Venereology, Ordensklinikum Linz Elisabethinen, Linz, Austria., Thune T; Department of Dermatology, Haukeland University Hospital, Bergen, Norway., Tsiogka A; 1st Department of Dermatology-Venereology, Faculty of Medicine, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece., Vassileva S; Department of Dermatology and Venereology, University Hospital 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Voswinkel L; The German Lichen Sclerosus Association, Hamburg, Germany., Wölber L; Department of Gynaecology, University Medical Centre Hamburg-Eppendorf and Centre for Colposcopy and Vulvovaginal Disease Jersualem Hospital Hamburg, Hamburg, Germany., Werner RN; Division of Evidence-Based Medicine (dEBM), Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
المصدر:	Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2024 Jun 01. Date of Electronic Publication: 2024 Jun 01.
Publication Model:	Ahead of Print
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9216037 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3083 (Electronic) Linking ISSN: 09269959 NLM ISO Abbreviation: J Eur Acad Dermatol Venereol Subsets: MEDLINE
أسماء مطبوعة:	Publication: Oxford : Wiley-Blackwell Original Publication: Amsterdam ; New York : Elsevier Science Publishers, c1992-
مستخلص:	Introduction: Lichen sclerosus (LS) is an inflammatory skin disease affecting all ages. LS typically involves the anogenital site where it causes itching and soreness; it may lead to sexual and urinary dysfunction in females and males; however, it may be asymptomatic. First signs of LS are usually a whitening of the genital skin, sometimes preceded by redness and oedema; fissuring, scarring, shrinkage and fusion of structures may follow in its course. LS is associated with an increased risk of genital cancer. LS has a huge impact on the quality of life of affected patients, and it is important to raise more awareness of this not uncommon disease in order to diagnose and treat it early. Objectives: The guideline intends to provide guidance on the diagnostic of LS (part 1), highlight important aspects in the care of LS patients, generate recommendations and treatment algorithms (part 2) on topical, interventional and surgical therapy, based on the latest evidence, provide guidance in the management of LS patients during pregnancy, provide guidance for the follow-up of patients with LS and inform about new developments and potential research aspects. Materials and Methods: The guideline was developed in accordance with the EuroGuiDerm Methods Manual v1.3 https://www.edf.one/de/home/Guidelines/EDF-EuroGuiDerm.html. The wording of the recommendations was standardized (as suggested by the GRADE Working Group). The guideline development group is comprised of 34 experts from 16 countries, including 5 patient representatives. Results: Ultrapotent or potent topical corticosteroids in females and males, adults and children remain gold standard of care for genital LS; co-treatment with emollients is recommended. If standard treatment fails in males, a surgical intervention is recommended, complete circumcision may cure LS in males. UV light treatment is recommended for extragenital LS; however, there is limited scientific evidence. Topical calcineurin inhibitors are second line treatment. Laser treatment, using various wave lengths, is under investigation, and it can currently not be recommended for the treatment of LS. Treatment with biologics is only reported in single cases. Conclusions: LS has to be diagnosed and treated as early as possible in order to minimize sequelae like scarring and cancer development. Topical potent and ultrapotent corticosteroids are the gold standard of care; genital LS is often a lifelong disease and needs to be treated long-term. (© 2024 European Academy of Dermatology and Venereology.)
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معلومات مُعتمدة:	EuroGuiDerm Centre for Guideline Development
تواريخ الأحداث:	Date Created: 20240601 Latest Revision: 20240601
رمز التحديث:	20240602
DOI:	10.1111/jdv.20083
PMID:	38822598
قاعدة البيانات:	MEDLINE

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تدمد:	1468-3083
DOI:	10.1111/jdv.20083