دورية أكاديمية
The prevalence of alloantibodies and ABO RhD blood groups in a cohort of Aboriginal and non-Aboriginal cardiac surgery patients from Australia.
| العنوان: | The prevalence of alloantibodies and ABO RhD blood groups in a cohort of Aboriginal and non-Aboriginal cardiac surgery patients from Australia. |
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| المؤلفون: | Sinha R; College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia. Electronic address: romi.sinha@flinders.edu.au., Baker RA; College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia; Cardiac and Thoracic Surgery Unit, Flinders Medical Centre, South Australia, Australia., Noutsos T; College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia; Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia; Department of Haematology, Royal Darwin Hospital, Darwin, Northern Territory, Australia., Perry M; Queensland University of Technology, Brisbane, Queensland, Australia; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Roxby D; College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia. |
| المصدر: | Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2024 Aug; Vol. 63 (4), pp. 103957. Date of Electronic Publication: 2024 May 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Country of Publication: England NLM ID: 101095653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0502 (Print) Linking ISSN: 14730502 NLM ISO Abbreviation: Transfus Apher Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Pergamon : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | ABO Blood-Group System*/immunology , Cardiac Surgical Procedures*/methods , Isoantibodies*/blood, Aged ; Female ; Humans ; Male ; Middle Aged ; Australia ; Prevalence ; Retrospective Studies ; Rh-Hr Blood-Group System/immunology ; Australian Aboriginal and Torres Strait Islander Peoples |
| مستخلص: | Introduction: Limited evidence exists on the distribution of ABO RhD blood groups and prevalence and specificity of red blood cell (RBC) alloantibodies in Aboriginal and Torres Strait Islander peoples of Australia. We investigated RBC alloantibody prevalence and ABO RhD groups in Aboriginal patients undergoing cardiac surgery at a South Australian (SA) tertiary hospital, a major cardiac surgical referral centre for Northern Territory (NT) patients METHODS: Retrospective analysis of all consecutive patients undergoing cardiac surgery at Flinders Medical Centre (FMC) between January 2014 and June 2019. ABO and RhD blood groups, and RBC alloantibody prevalence, specificity, and clinical significance in Aboriginal and non-Aboriginal cardiac patients were determined at time of surgery and on follow up to 2021. Results: 2327 patients were included, 588 (25.3 %) were from NT, and 420 (18.0 %) were Aboriginal. Aboriginal patients had a higher prevalence of ABO group O (59.8 % vs 43.9 %) and RhD positive (99.0 % vs 83.8 %). One-hundred-and-eleven patients had 154 RBC alloantibodies, 57/420 (13.6 %) Aboriginal versus 54/1907 (2.8 %) non-Aboriginal (p < 0.0001). There were higher numbers of IgM alloantibodies in Aboriginal patients (59/77, 76.6 %), with Lewis, P1 and M more common. Sixty patients had antibodies detected at time of surgery, 14 NT patients with previously detected alloantibodies, prior to surgery, presented with a negative antibody screen and 37 had new antibodies detected after cardiac surgery. Conclusion: A high prevalence of IgM alloantibodies was found in Aboriginal compared to non-Aboriginal cardiac surgery patients. The clinical significance of these IgM alloantibodies in Aboriginal peoples requires further investigation. Competing Interests: Conflict of interest There is no conflict of interest. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ABO Blood Group System; Aboriginal Australia; Immunoglobulin |
| المشرفين على المادة: | 0 (ABO Blood-Group System) 0 (Isoantibodies) 0 (Rh-Hr Blood-Group System) |
| تواريخ الأحداث: | Date Created: 20240601 Date Completed: 20240802 Latest Revision: 20240813 |
| رمز التحديث: | 20240814 |
| DOI: | 10.1016/j.transci.2024.103957 |
| PMID: | 38823359 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1473-0502 |
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| DOI: | 10.1016/j.transci.2024.103957 |