دورية أكاديمية
Oral DHA supplementation and retinopathy of prematurity: the Joinville DHA Clinical Trial.
| العنوان: | Oral DHA supplementation and retinopathy of prematurity: the Joinville DHA Clinical Trial. |
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| المؤلفون: | Cagliari PZ; Postgraduate Program in Health and Environment, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil.; Darcy Vargas Maternity Hospital, Joinville, SC89.202-190, Brazil.; Medicine Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil., Hoeller VRF; Medicine Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil., Kanzler ÉLR; Medicine Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil., Carraro MCM; Darcy Vargas Maternity Hospital, Joinville, SC89.202-190, Brazil., Corrêa ZGD; Nursing Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil., Blazius G; Nursing Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil., Marghetti PG; Nursing Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil., Lenz GB; Medicine Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil., Mastroeni SSBS; Postgraduate Program in Health and Environment, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil.; Medicine Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil.; Nursing Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil.; Nutrition Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil., Mastroeni MF; Postgraduate Program in Health and Environment, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil.; Medicine Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil.; Nursing Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil.; Nutrition Department, University of Joinville Region - UNIVILLE, Joinville, SC89.219-710, Brazil. |
| المصدر: | The British journal of nutrition [Br J Nutr] 2024 Jun 03, pp. 1-10. Date of Electronic Publication: 2024 Jun 03. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 0372547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2662 (Electronic) Linking ISSN: 00071145 NLM ISO Abbreviation: Br J Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000->: Wallingford, Oxon, UK : Published on behalf of the Nutrition Society by CABI Publishing Original Publication: [Cambridge, New York] Cambridge University Press. |
| مستخلص: | Retinopathy of prematurity (ROP) is a leading cause of blindness in premature infants. The condition is associated with DHA deficiency. This study aimed to investigate the effect of DHA supplementation on the occurrence of ROP in infants receiving oral oil drops. It is part of the Joinville DHA study, a non-parallel-group cohort study conducted from March 2020 to January 2023 at a public maternity hospital in Brazil. Infants born before 33 weeks of gestational age or with a birth weight ≤ 1500 g were recruited. Among 155 infants, 81 did not receive and 74 received DHA supplementation until complete vascularisation of the peripheral retina. There was a higher incidence of infants with ROP in the unsupplemented group (58·6 %) compared with the DHA group (41·4 %), but this difference was NS ( P = 0·22). Unadjusted logistic regression analysis showed that patent ductus arteriosus and neonatal corticosteroids were significantly ( P < 0·05) associated with ROP in both groups. In the DHA group, surfactant use was also associated with ROP ( P = 0·003). After adjusting for important covariates, patent ductus arteriosus and neonatal corticosteroids continued to be significant for infants in the unsupplemented group (OR = 3·99; P = 0·022 and OR = 5·64; P = 0·019, respectively). In the DHA group, only surfactant use continued to be associated with ROP (OR = 4·84; P = 0·015). In summary, DHA supplementation was not associated with ROP. Further studies are necessary to better understand the relationship between DHA supplementation, ROP and associated comorbidities. |
| فهرسة مساهمة: | Keywords: DHA; Patent ductus arteriosus; Preterm infant; Retinopathy of prematurity; Surfactant |
| تواريخ الأحداث: | Date Created: 20240603 Latest Revision: 20240807 |
| رمز التحديث: | 20240807 |
| DOI: | 10.1017/S0007114524001120 |
| PMID: | 38826072 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1475-2662 |
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| DOI: | 10.1017/S0007114524001120 |